iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-108	363.5	145	685

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLISEVWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk..............eknkpkeeeeeedkselsde.................................. 129
           qqD+qEfl++l+dql+eelk+              +++++++e ++ d+s ++de                                  
   Q: 229  QQDTQEFLRCLMDQLHEELKEpmvaavaaltdardSDSSDTDERRDGDRSPSEDEflscdsssdrgegdgqgrgggsskaemellisde 317
           *******************997776665555555444444445555554544444********************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 318  agraisekermkdrkfswgqqrtnseqvdedadvdtamasldeqsreaqppsprptspcqtpepdnevhirsssrpcspvhhheghtkl 406
           ***************************************************************************************** PP
   S: 130  ...........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...... 185
                                       +++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+      
   Q: 407  sssppraspvrmgpsyvlkkaqvpstgGRRRKEQSYRSVISDVFNGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiyq 495
           ***************************99*************************************************99888****** PP
   S: 186  ...........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLi 231
                                                      +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+  lPe+L+
   Q: 496  nvpakpgacgdsyssqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLCLPEILC 584
           ***************************************************************************************** PP
   S: 232  lhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevk 318
           +hLkRf  ++e + + k++++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+
   Q: 585  VHLKRF--RHEVMYSFKVSSHVSFPLEgLDLRPFLAKECTSQ--VTTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVH 669
           ******..9999***************************999..9**************************78999************* PP
   S: 319  eeevleetgstaYvlfYkr 337
           e+ v++    +aYvlfY++
   Q: 670  ETVVQN---VEAYVLFYRK 685
           ******...9*******98 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MGDARDICPH LDSIGEVTKE DLLLKSKGTC QSCGVAGPNL WACLQVTCPY VGCGESFADH 60
SSIHAQVKRH NLTVNLTTLR VWCYACEREV FLEQRLAVHL PSSSARLSEQ DSPPPCHPLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACAAGACTA TGCGCATCGC CGCGGTGGGC GCGCTTGACT GACAGGCGGC GCGGTTGCGA 60
CGGCAGGTGA GTTTCTGACG GCTGCTGCCT GCTGCCGGGG GCTGGGCCGC TAGAGCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:311856

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	90.82	0.00e+00	1654.00
IUUC-Apl-003351	Anas platyrhynchos	83.48	0.00e+00	1550.00
IUUC-Aca-005077	Anolis carolinensis	75.20	0.00e+00	1102.00
IUUC-Ame-011777	Astyanax mexicanus	74.27	0.00e+00	1330.00
IUUC-Bta-013063	Bos taurus	92.02	0.00e+00	1662.00
IUUC-Cja-019868	Callithrix jacchus	91.48	0.00e+00	1706.00
IUUC-Cfa-020761	Canis familiaris	90.38	0.00e+00	1654.00
IUUC-Cpo-022267	Cavia porcellus	85.28	0.00e+00	1540.00
IUUC-Csa-024251	Chlorocebus sabaeus	92.13	0.00e+00	1710.00
IUUC-Cho-024483	Choloepus hoffmanni	93.40	1.00e-120	427.00
IUUC-Csv-025889	Ciona savignyi	45.00	1.00e-36	145.00
IUUC-Dre-028061	Danio rerio	72.63	0.00e+00	1197.00
IUUC-Dno-029423	Dasypus novemcinctus	91.58	0.00e+00	1670.00
IUUC-Dor-030877	Dipodomys ordii	89.67	0.00e+00	1077.00
IUUC-Dme-031837	Drosophila melanogaster	49.13	1.00e-138	487.00
IUUC-Ete-032802	Echinops telfairi	78.06	9.00e-131	461.00
IUUC-Eca-034283	Equus caballus	90.27	0.00e+00	1645.00
IUUC-Eeu-034620	Erinaceus europaeus	88.16	0.00e+00	1176.00
IUUC-Fca-036357	Felis catus	90.71	0.00e+00	1637.00
IUUC-Fal-037411	Ficedula albicollis	84.11	0.00e+00	1552.00
IUUC-Gga-041101	Gallus gallus	83.83	0.00e+00	1536.00
IUUC-Gac-041315	Gasterosteus aculeatus	72.99	0.00e+00	1317.00
IUUC-Ggo-045600	Gorilla gorilla	91.41	0.00e+00	1651.00
IUUC-Hsa-045825	Homo sapiens	92.24	0.00e+00	1669.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	79.83	0.00e+00	1387.00
IUUC-Lch-050002	Latimeria chalumnae	73.97	0.00e+00	1310.00
IUUC-Loc-052574	Lepisosteus oculatus	76.40	0.00e+00	1393.00
IUUC-Laf-054428	Loxodonta africana	90.62	0.00e+00	1646.00
IUUC-Mcc-055736	Macaca mulatta	91.91	0.00e+00	1706.00
IUUC-Mga-059781	Meleagris gallopavo	82.97	0.00e+00	1533.00
IUUC-Mdo-063048	Monodelphis domestica	84.31	0.00e+00	1502.00
IUUC-Mmu-064079	Mus musculus	98.36	0.00e+00	1751.00
IUUC-Mpu-066616	Mustela putorius furo	89.64	0.00e+00	1688.00
IUUC-Mlu-067294	Myotis lucifugus	90.05	0.00e+00	1608.00
IUUC-Nle-070015	Nomascus leucogenys	91.69	0.00e+00	1628.00
IUUC-Opr-070328	Ochotona princeps	89.86	0.00e+00	1656.00
IUUC-Ont-071464	Oreochromis niloticus	74.10	0.00e+00	1306.00
IUUC-Oan-073259	Ornithorhynchus anatinus	76.64	0.00e+00	1290.00
IUUC-Ocu-074630	Oryctolagus cuniculus	88.09	0.00e+00	1574.00
IUUC-Ola-087240	Oryzias latipes	73.64	0.00e+00	1289.00
IUUC-Oga-088761	Otolemur garnettii	90.49	0.00e+00	1667.00
IUUC-Oar-089490	Ovis aries	86.99	0.00e+00	1502.00
IUUC-Ptr-091662	Pan troglodytes	92.02	0.00e+00	1665.00
IUUC-Pan-092199	Papio anubis	91.71	0.00e+00	1700.00
IUUC-Psi-093726	Pelodiscus sinensis	85.06	0.00e+00	1562.00
IUUC-Pma-094389	Petromyzon marinus	63.64	4.00e-100	357.00
IUUC-Pfo-096522	Poecilia formosa	71.74	0.00e+00	945.00
IUUC-Pab-098632	Pongo abelii	91.69	0.00e+00	1653.00
IUUC-Pca-100614	Procavia capensis	84.39	0.00e+00	1291.00
IUUC-Pva-102922	Pteropus vampyrus	87.95	0.00e+00	957.00
IUUC-Sha-106601	Sarcophilus harrisii	82.92	0.00e+00	1483.00
IUUC-Ssc-115533	Sus scrofa	90.28	0.00e+00	1635.00
IUUC-Tgu-117364	Taeniopygia guttata	83.95	0.00e+00	1523.00
IUUC-Tru-117770	Takifugu rubripes	70.29	0.00e+00	1286.00
IUUC-Tni-120001	Tetraodon nigroviridis	72.61	0.00e+00	1266.00
IUUC-Ttr-128732	Tursiops truncatus	91.37	0.00e+00	1657.00
IUUC-Xtr-132157	Xenopus tropicalis	75.38	0.00e+00	1347.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence