iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041520

UUCD1 version

UUC-GaA-00288

Ensembl Protein ID

ENSGACP00000007777.1

UniProt Accession

G3NR11; G3NR11_GASAC

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000005875.1	ENSGACT00000007796.1	ENSGACP00000007777.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-135	451.9	571	903

Active Site

Position(s)	Description	Evidence
872	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 571  PQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFKFIGRFIAMALFHGKFIDT 658
           5899********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l l+dle++dpe+y+sl +ik+n   +iee+gl++ fsv++eilge++++eLkp+G n++Vt+eNkeeY++lv+e
   Q: 659  GFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKDN---NIEECGLEMFFSVDKEILGEVTTHELKPDGGNVQVTEENKEEYIRLVAE 744
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+++cG++eid+ d+++++ y++ y ++s++i wFw++++e+++e+r ++LqFv
   Q: 745  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLVDWQRNAIYRH-YARSSKQILWFWQFVKEMDNEKRMRLLQFV 832
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekL++Aieet+gF++
   Q: 833  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLMFAIEETEGFGQ 903
           *********************************************************************96 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

TMKAQLQVTV LSAKLKENKK NWFGPSPYVE VAVDGQSKRT EKCNNTHSPK WKQAVTVIVT 60
PVSKLIFRVW GHQTLKADIL LGMAILEISE TLKGNDLRLC EVVQTLQLCS DRDPRDIVGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCATGAAGG CCCAATTACA AGTCACAGGT AAGTTATTGG TTATCCTTGA AACATTGTAA 60
AGCCTGTTTA TCAACAGATT TGACCCTCTG ATTTCTGTAT TATCCGGCTA TCGGGAGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005338	Anolis carolinensis	87.86	0.00e+00	1102.00
IUUC-Ame-010601	Astyanax mexicanus	92.44	0.00e+00	1170.00
IUUC-Bta-012782	Bos taurus	89.43	0.00e+00	1112.00
IUUC-Cja-018899	Callithrix jacchus	85.86	0.00e+00	1116.00
IUUC-Cfa-020648	Canis familiaris	87.54	0.00e+00	1084.00
IUUC-Csa-023252	Chlorocebus sabaeus	84.87	0.00e+00	1112.00
IUUC-Dre-028809	Danio rerio	94.19	0.00e+00	1168.00
IUUC-Eca-033793	Equus caballus	89.25	0.00e+00	1112.00
IUUC-Eeu-034716	Erinaceus europaeus	85.00	0.00e+00	830.00
IUUC-Gmo-038596	Gadus morhua	86.76	0.00e+00	1075.00
IUUC-Ggo-044535	Gorilla gorilla	82.89	0.00e+00	1082.00
IUUC-Loc-052647	Lepisosteus oculatus	92.89	0.00e+00	1167.00
IUUC-Mcc-055532	Macaca mulatta	84.87	0.00e+00	1112.00
IUUC-Ont-071798	Oreochromis niloticus	95.04	0.00e+00	1213.00
IUUC-Pfo-096937	Poecilia formosa	95.25	0.00e+00	1190.00
IUUC-Pab-097580	Pongo abelii	83.97	0.00e+00	985.00
IUUC-Sar-113761	Sorex araneus	89.08	0.00e+00	1105.00
IUUC-Sre-114929	Sporisorium reilianum	46.81	2.00e-151	529.00
IUUC-Tru-118658	Takifugu rubripes	92.05	0.00e+00	1166.00
IUUC-Tni-120168	Tetraodon nigroviridis	93.88	0.00e+00	1144.00
IUUC-Tbe-127756	Tupaia belangeri	74.09	0.00e+00	811.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence