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Tag Content
UUCD2 ID IUUC-Itr-048512
UUCD1 version UUC-SpT-00210
Ensembl Protein ID ENSSTOP00000000449.2
UniProt Accession I3LWR9; I3LWR9_ICTTR
Genbank Protein ID ENSSTOP00000000449
Protein Name Breast cancer type 1 susceptibility protein homolog
Genbank Nucleotide ID AGTP01023532
Gene Name BRCA1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSTOG00000000494.2 ENSSTOT00000000497.2 ENSSTOP00000000449.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 74.19 0.00e+00 2698.00 IUUC-Hsa-046086
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Ictidomys tridecemlineatus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.
 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.
Protein Sequence
(Fasta)
MDLSAVRVEE VQNVLNAMQK ILECPICLEL IKEPVSTKCD HIFCNFSVLR ALNHSLGVFC 60
CCCCRNYILY LSLQESTRFS QLVEELLKII HAFELDTGLQ FANSYNFPKK ENNSPEHLKE 120
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Protein Fasta Sequence


>IUUC-Itr-048512|E3,RING|Ictidomys tridecemlineatus
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Nucleotide Sequence
(Fasta)
ATGGATTTAT CTGCAGTTCG TGTTGAAGAA GTACAAAATG TCCTTAATGC TATGCAGAAA 60
ATCTTAGAGT GTCCAATTTG GTAAGTCAAC AGAAGAGTTT ATTAGTTTGT GATTCTTCCT 120
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Nucleotide Fasta Sequence


>IUUC-Itr-048512|E3,RING|Ictidomys tridecemlineatus
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Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50172--BRCT
Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PRINTS

PR00493--BRSTCANCERI
SMART

SM00292--BRCT
Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002388 Ailuropoda melanoleuca 70.50 0.00e+00 2496.00
IUUC-Apl-003252 Anas platyrhynchos 35.71 2.00e-122 434.00
IUUC-Aca-004526 Anolis carolinensis 52.00 8.00e-74 271.00
IUUC-Ame-011720 Astyanax mexicanus 47.60 1.00e-53 205.00
IUUC-Bta-013433 Bos taurus 68.38 0.00e+00 2391.00
IUUC-Cja-019149 Callithrix jacchus 72.67 0.00e+00 2557.00
IUUC-Cfa-020322 Canis familiaris 69.86 0.00e+00 2429.00
IUUC-Cpo-021583 Cavia porcellus 45.97 0.00e+00 1362.00
IUUC-Cre-022955 Chlamydomonas reinhardtii 30.40 3.00e-06 47.80
IUUC-Csa-024227 Chlorocebus sabaeus 72.13 2.00e-155 542.00
IUUC-Cho-024530 Choloepus hoffmanni 66.24 0.00e+00 1170.00
IUUC-Cin-025364 Ciona intestinalis 29.13 1.00e-10 60.50
IUUC-Dno-029247 Dasypus novemcinctus 68.48 0.00e+00 2024.00
IUUC-Ete-032472 Echinops telfairi 52.88 0.00e+00 1603.00
IUUC-Eca-033446 Equus caballus 72.86 0.00e+00 2652.00
IUUC-Eeu-034858 Erinaceus europaeus 62.88 0.00e+00 948.00
IUUC-Fca-035991 Felis catus 71.88 0.00e+00 2575.00
IUUC-Fal-036803 Ficedula albicollis 29.81 2.00e-93 337.00
IUUC-Gmo-038782 Gadus morhua 45.64 1.00e-45 178.00
IUUC-Gga-040969 Gallus gallus 60.28 2.00e-77 284.00
IUUC-Gac-042296 Gasterosteus aculeatus 43.44 1.00e-50 195.00
IUUC-Ggo-044740 Gorilla gorilla 71.64 0.00e+00 2467.00
IUUC-Hsa-046086 Homo sapiens 74.19 0.00e+00 2549.00
IUUC-Lch-049789 Latimeria chalumnae 54.30 7.00e-73 269.00
IUUC-Loc-051952 Lepisosteus oculatus 49.78 2.00e-65 244.00
IUUC-Laf-053648 Loxodonta africana 69.97 0.00e+00 2382.00
IUUC-Mcc-055210 Macaca mulatta 73.52 0.00e+00 2618.00
IUUC-Meu-056342 Macropus eugenii 37.25 3.00e-119 423.00
IUUC-Mga-060163 Meleagris gallopavo 52.77 4.00e-80 293.00
IUUC-Mmr-061402 Microcebus murinus 73.01 0.00e+00 867.00
IUUC-Mdo-062209 Monodelphis domestica 45.61 0.00e+00 1281.00
IUUC-Mmu-064003 Mus musculus 55.87 0.00e+00 1805.00
IUUC-Mpu-065825 Mustela putorius furo 64.93 0.00e+00 763.00
IUUC-Mlu-068176 Myotis lucifugus 68.77 0.00e+00 2279.00
IUUC-Nle-069178 Nomascus leucogenys 74.35 0.00e+00 2595.00
IUUC-Opr-070574 Ochotona princeps 58.07 0.00e+00 1918.00
IUUC-Ont-072380 Oreochromis niloticus 48.61 6.00e-59 223.00
IUUC-Oan-073243 Ornithorhynchus anatinus 59.52 1.00e-22 98.20
IUUC-Ocu-074424 Oryctolagus cuniculus 67.45 0.00e+00 2347.00
IUUC-Ola-086863 Oryzias latipes 43.82 5.00e-54 206.00
IUUC-Oar-089938 Ovis aries 68.39 0.00e+00 2454.00
IUUC-Ptr-090960 Pan troglodytes 74.88 0.00e+00 2594.00
IUUC-Pan-092609 Papio anubis 72.43 0.00e+00 2269.00
IUUC-Psi-093889 Pelodiscus sinensis 29.17 1.00e-51 198.00
IUUC-Pfo-096328 Poecilia formosa 50.92 2.00e-61 231.00
IUUC-Pab-097982 Pongo abelii 74.56 0.00e+00 2609.00
IUUC-Pca-100698 Procavia capensis 64.46 0.00e+00 674.00
IUUC-Pva-102631 Pteropus vampyrus 72.46 0.00e+00 1114.00
IUUC-Rno-105879 Rattus norvegicus 56.50 0.00e+00 1817.00
IUUC-Sha-106701 Sarcophilus harrisii 39.43 0.00e+00 683.00
IUUC-Sit-110609 Setaria italica 26.38 4.00e-18 87.00
IUUC-Sar-113047 Sorex araneus 60.43 0.00e+00 1436.00
IUUC-Ssc-115846 Sus scrofa 70.57 0.00e+00 2522.00
IUUC-Tgu-116785 Taeniopygia guttata 51.82 2.00e-77 284.00
IUUC-Tru-117895 Takifugu rubripes 42.63 3.00e-52 200.00
IUUC-Tsy-118885 Tarsius syrichta 58.56 0.00e+00 697.00
IUUC-Tni-119654 Tetraodon nigroviridis 44.60 3.00e-48 187.00
IUUC-Tbe-127421 Tupaia belangeri 60.34 2.00e-157 550.00
IUUC-Ttr-128685 Tursiops truncatus 71.54 0.00e+00 2438.00
IUUC-Vpa-130216 Vicugna pacos 63.66 0.00e+00 764.00
IUUC-Xtr-132398 Xenopus tropicalis 37.39 4.00e-63 236.00
Created Date 25-Jun-2017

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