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Tag Content
UUCD2 ID IUUC-Csv-025817
UUCD1 version UUC-CiS-00210
Ensembl Protein ID ENSCSAVP00000009297.1
UniProt Accession H2YVD7; H2YVD7_CIOSA
Protein Name Lissencephaly-1 homolog
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCSAVG00000005483.1 ENSCSAVT00000009414.1 ENSCSAVP00000009297.1
ENSCSAVG00000005483.1 ENSCSAVT00000009415.1 ENSCSAVP00000009298.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.80e-52 171.9 188 226
UBD/Beta-Prp 2.80e-87 292.6 105 408
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH v++++f +d +++vs+s+D+t+k+W l tg ++k
   Q: 188 GHDHNVSSVSFmPDgDHIVSASRDKTVKLWQLATGYCIK 226
    899*********999*******************98887 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
    h s+it v f+p + l++++ +d+tikvwd++tg++ r+l+gh++ v++++f+p+gkil+++s D +k+wd+ ++c+ tl+gh+++
   Q: 105 HRSPITRVIFHPVYGLVLSAAEDSTIKVWDYETGDFERTLKGHTDSVQDISFDPTGKILASCSADLSVKIWDFVEFECTKTLTGHDHN 192
    678************************************************************************************* PP
   S: 97 vlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
    v s+sf+p+gd++vs+s+d+t+++w+l tg+c++ t sgh+++v++v+ + dg+ll+s+s+D+t+r+W ++t ++ +l+ h++ v+
   Q: 193 VSSVSFMPDGDHIVSASRDKTVKLWQLATGYCIK-TYSGHKEWVRMVRPNIDGSLLASCSNDQTIRVWLSATTECKVELRD-HDHVVE 278
    **********************************.*********************************************8.****** PP
   S: 185 slsfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlr 252
    +l++ +++ +++vsgs+d+t+k+wd++t++c+ tl+gh+++v+ f+p++++l+++s+D+++r+Wd++
   Q: 279 CLAWAPESavpnicaaagiefrkgenagPFIVSGSRDKTLKVWDVSTSQCLFTLIGHDSWVRAAMFHPRGKFLITASDDKTLRVWDIK 366
    **************************************************************************************** PP
   S: 253 sgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ + ktl+ h++ v+ +v + + +++++gs d v++w+++
   Q: 367 NKRCHKTLAAHEHFVTDLDV-HKSAPYIITGSVDLLVKVWECR 408
    ********************.99*****************985 PP
   

Organism Ciona savignyi
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
Protein Sequence
(Fasta)
MVLSTRQRDE LNLAISEYLR SNGYSKALEA FKEEADLSDQ VDKKYDGLME KKWTSVVRLQ 60
RKVMDLEAKL NELTKETRDG ITPQHKKDPS EWIPRPPERY ALSGHRSPIT RVIFHPVYGL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Csv-025817|E3,WD_repeat;UBD,Beta-Prp|Ciona savignyi
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTACCCACTG TTTTAGTAGT TGATTAATGT AGGTATGCTT CAGTAGAAGC CATGGTTTTG 60
TCAACGAGGC AAAGGGATGA GCTGTAAGTT TTTCCATCAG TAAATAATTT TATAATGTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Csv-025817|E3,WD_repeat;UBD,Beta-Prp|Ciona savignyi
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 68.92 6.00e-178 615.00
IUUC-Apl-004024 Anas platyrhynchos 69.51 0.00e+00 634.00
IUUC-Aca-004564 Anolis carolinensis 69.27 0.00e+00 627.00
IUUC-Ago-007862 Ashbya gossypii 27.56 1.00e-35 142.00
IUUC-Acl-008360 Aspergillus clavatus 44.58 5.00e-99 352.00
IUUC-Afl-008502 Aspergillus flavus 44.01 4.00e-90 323.00
IUUC-Afu-008848 Aspergillus fumigatus 44.34 9.00e-100 355.00
IUUC-Ani-009173 Aspergillus nidulans 39.65 8.00e-84 302.00
IUUC-Ang-009873 Aspergillus niger 42.13 8.00e-89 318.00
IUUC-Aor-009973 Aspergillus oryzae 41.92 3.00e-87 313.00
IUUC-Ate-010523 Aspergillus terreus 37.81 1.00e-83 301.00
IUUC-Ame-010969 Astyanax mexicanus 70.24 0.00e+00 642.00
IUUC-Bgr-011972 Blumeria graminis 44.80 1.00e-99 355.00
IUUC-Bta-013106 Bos taurus 69.51 0.00e+00 635.00
IUUC-Bci-013615 Botrytis cinerea 42.75 7.00e-95 339.00
IUUC-Cel-018459 Caenorhabditis elegans 53.06 3.00e-138 483.00
IUUC-Cja-018755 Callithrix jacchus 67.32 2.00e-178 616.00
IUUC-Cfa-020749 Canis familiaris 69.51 0.00e+00 635.00
IUUC-Cpo-022371 Cavia porcellus 69.51 0.00e+00 635.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 34.81 9.00e-51 191.00
IUUC-Csa-023524 Chlorocebus sabaeus 69.28 1.00e-155 540.00
IUUC-Cho-024764 Choloepus hoffmanni 62.80 1.00e-147 514.00
IUUC-Cin-025753 Ciona intestinalis 91.00 0.00e+00 756.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 45.45 1.00e-93 335.00
IUUC-Cne-027087 Cryptococcus neoformans 50.52 2.00e-107 380.00
IUUC-Dre-028314 Danio rerio 70.00 0.00e+00 640.00
IUUC-Dno-029050 Dasypus novemcinctus 69.27 0.00e+00 634.00
IUUC-Dor-030222 Dipodomys ordii 64.39 3.00e-166 575.00
IUUC-Dse-031164 Dothistroma septosporum 43.52 9.00e-96 342.00
IUUC-Dme-031745 Drosophila melanogaster 65.04 2.00e-162 563.00
IUUC-Ete-032508 Echinops telfairi 71.12 1.00e-128 451.00
IUUC-Eca-034288 Equus caballus 68.92 3.00e-177 612.00
IUUC-Eeu-034984 Erinaceus europaeus 64.39 8.00e-166 574.00
IUUC-Fca-036498 Felis catus 69.51 0.00e+00 635.00
IUUC-Fal-036920 Ficedula albicollis 69.51 0.00e+00 634.00
IUUC-Fox-037996 Fusarium oxysporum 45.08 3.00e-99 353.00
IUUC-Fso-038160 Fusarium solani 43.91 6.00e-97 345.00
IUUC-Gmo-039166 Gadus morhua 70.00 0.00e+00 638.00
IUUC-Ggr-040051 Gaeumannomyces graminis 46.65 3.00e-97 347.00
IUUC-Gga-040623 Gallus gallus 69.51 0.00e+00 634.00
IUUC-Gac-041613 Gasterosteus aculeatus 70.00 0.00e+00 637.00
IUUC-Ggo-045410 Gorilla gorilla 61.81 1.00e-153 534.00
IUUC-Hsa-046358 Homo sapiens 69.51 0.00e+00 634.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 69.51 0.00e+00 635.00
IUUC-Kpa-049351 Komagataella pastoris 28.44 2.00e-40 158.00
IUUC-Lch-049936 Latimeria chalumnae 69.27 0.00e+00 637.00
IUUC-Loc-052476 Lepisosteus oculatus 68.92 6.00e-178 615.00
IUUC-Lma-053170 Leptosphaeria maculans 46.53 1.00e-95 342.00
IUUC-Laf-053713 Loxodonta africana 67.97 3.00e-179 619.00
IUUC-Mcc-054628 Macaca mulatta 69.02 0.00e+00 632.00
IUUC-Meu-055927 Macropus eugenii 60.65 1.00e-103 367.00
IUUC-Mor-056962 Magnaporthe oryzae 46.32 4.00e-96 343.00
IUUC-Mpo-057583 Magnaporthe poae 47.13 3.00e-93 333.00
IUUC-Mla-058819 Melampsora laricipopulina 47.98 6.00e-111 392.00
IUUC-Mga-059945 Meleagris gallopavo 69.27 0.00e+00 633.00
IUUC-Mvi-060403 Microbotryum violaceum 53.08 4.00e-125 439.00
IUUC-Mmr-061289 Microcebus murinus 68.92 8.00e-178 614.00
IUUC-Mdo-061912 Monodelphis domestica 69.02 0.00e+00 630.00
IUUC-Mmu-063253 Mus musculus 69.51 0.00e+00 635.00
IUUC-Mpu-066638 Mustela putorius furo 69.51 0.00e+00 635.00
IUUC-Mlu-067267 Myotis lucifugus 68.14 1.00e-179 620.00
IUUC-Nfi-068571 Neosartorya fischeri 42.23 3.00e-92 330.00
IUUC-Ncr-068895 Neurospora crassa 47.92 2.00e-102 364.00
IUUC-Nle-069087 Nomascus leucogenys 69.25 4.00e-148 515.00
IUUC-Opr-070579 Ochotona princeps 69.27 0.00e+00 634.00
IUUC-Ont-072432 Oreochromis niloticus 70.24 0.00e+00 639.00
IUUC-Oan-073072 Ornithorhynchus anatinus 69.51 0.00e+00 635.00
IUUC-Ocu-074180 Oryctolagus cuniculus 69.27 0.00e+00 634.00
IUUC-Ola-086772 Oryzias latipes 70.24 0.00e+00 641.00
IUUC-Oga-088219 Otolemur garnettii 67.89 1.00e-178 617.00
IUUC-Oar-090394 Ovis aries 69.51 0.00e+00 635.00
IUUC-Ptr-091517 Pan troglodytes 69.51 0.00e+00 635.00
IUUC-Pan-092421 Papio anubis 69.02 0.00e+00 632.00
IUUC-Psi-093370 Pelodiscus sinensis 69.02 0.00e+00 631.00
IUUC-Pma-094319 Petromyzon marinus 70.20 2.00e-155 540.00
IUUC-Pno-094815 Phaeosphaeria nodorum 46.63 4.00e-101 359.00
IUUC-Pfo-097089 Poecilia formosa 70.00 0.00e+00 639.00
IUUC-Pab-098421 Pongo abelii 69.51 0.00e+00 635.00
IUUC-Pca-100120 Procavia capensis 50.74 6.00e-118 415.00
IUUC-Pva-102960 Pteropus vampyrus 69.27 0.00e+00 630.00
IUUC-Pgr-103538 Puccinia graminis 44.64 3.00e-108 383.00
IUUC-Ptt-103990 Puccinia triticina 40.48 2.00e-39 155.00
IUUC-Pte-104261 Pyrenophora teres 46.51 2.00e-101 360.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 46.75 1.00e-101 362.00
IUUC-Rno-105123 Rattus norvegicus 69.51 0.00e+00 635.00
IUUC-Sce-106208 Saccharomyces cerevisiae 30.10 1.00e-34 139.00
IUUC-Sha-107010 Sarcophilus harrisii 68.78 0.00e+00 629.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.58 7.00e-59 219.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 43.06 2.00e-95 341.00
IUUC-Sar-113309 Sorex araneus 68.17 4.00e-175 605.00
IUUC-Sre-115003 Sporisorium reilianum 46.12 5.00e-114 402.00
IUUC-Ssc-116148 Sus scrofa 69.51 0.00e+00 635.00
IUUC-Tgu-117299 Taeniopygia guttata 69.51 0.00e+00 634.00
IUUC-Tru-117721 Takifugu rubripes 70.00 0.00e+00 639.00
IUUC-Tsy-119493 Tarsius syrichta 69.27 0.00e+00 630.00
IUUC-Tni-120355 Tetraodon nigroviridis 70.24 0.00e+00 627.00
IUUC-Tre-121977 Trichoderma reesei 40.51 5.00e-93 333.00
IUUC-Tvi-122661 Trichoderma virens 42.03 1.00e-93 335.00
IUUC-Tme-127031 Tuber melanosporum 45.36 1.00e-99 355.00
IUUC-Tbe-127492 Tupaia belangeri 61.54 4.00e-88 316.00
IUUC-Ttr-128929 Tursiops truncatus 69.51 0.00e+00 632.00
IUUC-Uma-129347 Ustilago maydis 44.98 2.00e-113 400.00
IUUC-Vda-129837 Verticillium dahliae 45.80 2.00e-96 344.00
IUUC-Vpa-130532 Vicugna pacos 59.59 3.00e-139 486.00
IUUC-Xtr-131985 Xenopus tropicalis 68.54 0.00e+00 630.00
IUUC-Xma-133314 Xiphophorus maculatus 70.24 0.00e+00 641.00
IUUC-Yli-134403 Yarrowia lipolytica 40.00 5.00e-71 259.00
Created Date 25-Jun-2017

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