iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116580

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01045668

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000000375.1	ENSTGUT00000000388.1	ENSTGUP00000000383.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.30e-08	32.7	365	404

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    + +s  + CP Cr
   Q: 365  CKICAENDKD-VKIEPCGHLMCTSCLTAW----Q-ESEGQGCPFCR 404
           99********.******************....5.555555****8 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MSAPLKKGPG GLIGLMKDAF QPHHHHLGPH QPGAVDKKMV EKCWKLMDKV VRLCQNPKLA 60
LKNSPPYILD LLPDTYQHLR TILSRYEGKM ETLGENEYFR VFMENLMKKT KQTISLFKEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGGCAC CGCTGAAGAA GGGCCCCGGC GGGCTCATCG GGCTGATGAA GGACGCGTTC 60
CAGCCTCACC ACCACCACCT CGGGCCGCAC CAGCCCGGCG CCGTGGACAA GAAGATGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

tgu:100227293

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	82.83	0.00e+00	1338.00
IUUC-Apl-004041	Anas platyrhynchos	91.47	0.00e+00	1493.00
IUUC-Aca-004899	Anolis carolinensis	83.18	0.00e+00	1293.00
IUUC-Ame-010746	Astyanax mexicanus	78.16	1.00e-134	473.00
IUUC-Bta-012759	Bos taurus	82.58	0.00e+00	1381.00
IUUC-Cja-019207	Callithrix jacchus	81.27	0.00e+00	1369.00
IUUC-Cfa-020897	Canis familiaris	81.94	0.00e+00	1362.00
IUUC-Cpo-021453	Cavia porcellus	81.77	0.00e+00	1360.00
IUUC-Csa-023136	Chlorocebus sabaeus	81.34	0.00e+00	1362.00
IUUC-Cho-024282	Choloepus hoffmanni	74.18	0.00e+00	1120.00
IUUC-Cin-025574	Ciona intestinalis	70.81	4.00e-179	620.00
IUUC-Csv-025938	Ciona savignyi	69.37	3.00e-173	600.00
IUUC-Dre-027644	Danio rerio	67.03	0.00e+00	1041.00
IUUC-Dno-030025	Dasypus novemcinctus	82.70	0.00e+00	1333.00
IUUC-Dme-032213	Drosophila melanogaster	74.23	0.00e+00	645.00
IUUC-Eca-033900	Equus caballus	83.47	0.00e+00	1358.00
IUUC-Eeu-035142	Erinaceus europaeus	78.55	0.00e+00	872.00
IUUC-Fca-035455	Felis catus	81.67	0.00e+00	1344.00
IUUC-Fal-037182	Ficedula albicollis	100.00	0.00e+00	932.00
IUUC-Gmo-038698	Gadus morhua	88.49	0.00e+00	883.00
IUUC-Gga-040438	Gallus gallus	91.23	0.00e+00	1504.00
IUUC-Gac-042166	Gasterosteus aculeatus	71.34	0.00e+00	898.00
IUUC-Ggo-045618	Gorilla gorilla	82.09	0.00e+00	1379.00
IUUC-Hsa-046177	Homo sapiens	81.54	0.00e+00	1366.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	85.69	0.00e+00	908.00
IUUC-Lch-050095	Latimeria chalumnae	82.01	0.00e+00	1012.00
IUUC-Loc-052570	Lepisosteus oculatus	69.60	0.00e+00	1124.00
IUUC-Laf-054008	Loxodonta africana	82.05	0.00e+00	1375.00
IUUC-Mcc-054676	Macaca mulatta	81.23	0.00e+00	1359.00
IUUC-Mga-059239	Meleagris gallopavo	91.00	0.00e+00	1552.00
IUUC-Mmr-060907	Microcebus murinus	79.91	0.00e+00	1345.00
IUUC-Mdo-062595	Monodelphis domestica	83.99	0.00e+00	1337.00
IUUC-Mmu-063725	Mus musculus	82.00	0.00e+00	1404.00
IUUC-Mpu-066771	Mustela putorius furo	82.49	0.00e+00	1374.00
IUUC-Mlu-067206	Myotis lucifugus	96.88	0.00e+00	837.00
IUUC-Nle-069285	Nomascus leucogenys	79.34	0.00e+00	1285.00
IUUC-Opr-071026	Ochotona princeps	81.29	0.00e+00	1323.00
IUUC-Ont-071954	Oreochromis niloticus	69.76	0.00e+00	1063.00
IUUC-Ocu-074657	Oryctolagus cuniculus	81.91	0.00e+00	1314.00
IUUC-Ola-087165	Oryzias latipes	67.12	0.00e+00	1048.00
IUUC-Oga-088198	Otolemur garnettii	73.25	0.00e+00	1193.00
IUUC-Oar-090258	Ovis aries	82.76	0.00e+00	1332.00
IUUC-Ptr-090710	Pan troglodytes	81.54	0.00e+00	1366.00
IUUC-Pan-092785	Papio anubis	81.34	0.00e+00	1362.00
IUUC-Pfo-096990	Poecilia formosa	90.29	0.00e+00	832.00
IUUC-Pab-098526	Pongo abelii	81.41	0.00e+00	1364.00
IUUC-Pva-102352	Pteropus vampyrus	95.15	0.00e+00	881.00
IUUC-Rno-105876	Rattus norvegicus	81.47	0.00e+00	1390.00
IUUC-Sha-107588	Sarcophilus harrisii	82.51	0.00e+00	1174.00
IUUC-Sar-112959	Sorex araneus	80.05	0.00e+00	1289.00
IUUC-Ssc-115261	Sus scrofa	82.40	0.00e+00	1377.00
IUUC-Tru-118731	Takifugu rubripes	68.52	0.00e+00	1051.00
IUUC-Tsy-118982	Tarsius syrichta	71.87	0.00e+00	860.00
IUUC-Tni-120725	Tetraodon nigroviridis	68.87	0.00e+00	1041.00
IUUC-Tbe-128018	Tupaia belangeri	87.86	0.00e+00	1076.00
IUUC-Ttr-128927	Tursiops truncatus	82.91	0.00e+00	1404.00
IUUC-Vpa-130369	Vicugna pacos	81.80	0.00e+00	1285.00
IUUC-Xtr-132474	Xenopus tropicalis	73.78	0.00e+00	1170.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence