• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105027
Ensembl Protein ID ENSRNOP00000003198.5
UniProt Accession O08678; MARK1_RAT
Genbank Protein ID CAB06294.1
Protein Name Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1
Genbank Nucleotide ID Z83868
Gene Name Mark1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000002339.6 ENSRNOT00000080309.1 ENSRNOP00000074213.1
ENSRNOG00000002339.6 ENSRNOT00000003198.6 ENSRNOP00000003198.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACmiRNAMapRAID2
Protein-protein Interaction
IIDPINAHINT
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 94.34 0.00e+00 1412.00 IUUC-Hsa-046631
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
 Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Protein Sequence
(Fasta)
MSARTPLPTV NERDTENHTS VDGYTETHIP PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 60
RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105027|UBD,UBA|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGTCCTCGC CCGACTTCCC GCCCCGCGCC TGCGGGAGCG CGCGCTCCCG GCGCGGCCTG 60
CTCGCGCGCG CCCGCCCTCG CCGAAGCCCT CCTCGGCCCC GCGACCGCCG AGGACCCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105027|UBD,UBA|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0446--Lipid-binding
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0879--Wnt signaling pathway
Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR033627--MARK1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA
SMART

SM00220--S_TKc
SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0015630--C:microtubule cytoskeleton
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0070300--F:phosphatidic acid binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786--F:phosphatidylserine binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0007010--P:cytoskeleton organization
GO:0030010--P:establishment of cell polarity
GO:0035556--P:intracellular signal transduction
GO:0000226--P:microtubule cytoskeleton organization
GO:0001764--P:neuron migration
GO:0006468--P:protein phosphorylation
GO:0016055--P:Wnt signaling pathway
KEGG rno:117016
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001559 Ailuropoda melanoleuca 93.97 0.00e+00 1407.00
IUUC-Aca-004735 Anolis carolinensis 66.28 0.00e+00 1020.00
IUUC-Ame-011737 Astyanax mexicanus 70.76 0.00e+00 1029.00
IUUC-Bta-013462 Bos taurus 93.32 0.00e+00 1374.00
IUUC-Cja-019358 Callithrix jacchus 94.09 0.00e+00 1474.00
IUUC-Cfa-020498 Canis familiaris 93.06 0.00e+00 1356.00
IUUC-Cpo-022467 Cavia porcellus 91.02 0.00e+00 1390.00
IUUC-Csa-023035 Chlorocebus sabaeus 94.21 0.00e+00 1483.00
IUUC-Dre-028387 Danio rerio 67.80 0.00e+00 997.00
IUUC-Dno-029052 Dasypus novemcinctus 67.88 0.00e+00 1004.00
IUUC-Dor-031094 Dipodomys ordii 86.29 0.00e+00 1239.00
IUUC-Ete-032429 Echinops telfairi 83.52 0.00e+00 1221.00
IUUC-Eca-033265 Equus caballus 94.34 0.00e+00 1353.00
IUUC-Eeu-034949 Erinaceus europaeus 73.91 0.00e+00 701.00
IUUC-Fca-035360 Felis catus 88.85 0.00e+00 1290.00
IUUC-Fal-036617 Ficedula albicollis 88.76 0.00e+00 1181.00
IUUC-Gga-040502 Gallus gallus 71.71 0.00e+00 1065.00
IUUC-Gac-041559 Gasterosteus aculeatus 77.01 0.00e+00 1125.00
IUUC-Hsa-046631 Homo sapiens 94.34 0.00e+00 1486.00
IUUC-Lch-049551 Latimeria chalumnae 67.16 0.00e+00 1008.00
IUUC-Loc-052896 Lepisosteus oculatus 67.31 0.00e+00 1007.00
IUUC-Laf-054266 Loxodonta africana 91.63 0.00e+00 1384.00
IUUC-Mcc-054650 Macaca mulatta 94.34 0.00e+00 1482.00
IUUC-Meu-056525 Macropus eugenii 68.26 0.00e+00 981.00
IUUC-Mmr-060697 Microcebus murinus 67.24 0.00e+00 1007.00
IUUC-Mdo-061932 Monodelphis domestica 85.77 0.00e+00 1324.00
IUUC-Mmu-064104 Mus musculus 97.23 0.00e+00 1443.00
IUUC-Mpu-065989 Mustela putorius furo 92.70 0.00e+00 1135.00
IUUC-Mlu-067700 Myotis lucifugus 92.15 0.00e+00 1306.00
IUUC-Nle-069385 Nomascus leucogenys 93.31 0.00e+00 1462.00
IUUC-Opr-070302 Ochotona princeps 67.16 0.00e+00 997.00
IUUC-Ont-071262 Oreochromis niloticus 79.15 0.00e+00 1176.00
IUUC-Oan-073352 Ornithorhynchus anatinus 89.31 0.00e+00 1364.00
IUUC-Ocu-073777 Oryctolagus cuniculus 94.59 0.00e+00 1422.00
IUUC-Oar-089313 Ovis aries 90.16 0.00e+00 1355.00
IUUC-Ptr-091421 Pan troglodytes 94.09 0.00e+00 1477.00
IUUC-Pan-092891 Papio anubis 70.27 0.00e+00 1058.00
IUUC-Psi-093307 Pelodiscus sinensis 89.07 0.00e+00 1314.00
IUUC-Pma-094666 Petromyzon marinus 68.16 0.00e+00 1040.00
IUUC-Pab-098232 Pongo abelii 94.59 0.00e+00 1488.00
IUUC-Pca-100975 Procavia capensis 82.56 0.00e+00 830.00
IUUC-Pva-102596 Pteropus vampyrus 86.99 0.00e+00 1337.00
IUUC-Pgr-103687 Puccinia graminis 44.52 2.00e-68 254.00
IUUC-Sha-106668 Sarcophilus harrisii 87.17 0.00e+00 1310.00
IUUC-Ssc-115321 Sus scrofa 69.19 0.00e+00 950.00
IUUC-Tgu-116652 Taeniopygia guttata 88.81 0.00e+00 1383.00
IUUC-Tru-118387 Takifugu rubripes 60.61 0.00e+00 899.00
IUUC-Tsy-119138 Tarsius syrichta 82.04 0.00e+00 918.00
IUUC-Tni-120412 Tetraodon nigroviridis 78.25 0.00e+00 1156.00
IUUC-Tbe-127841 Tupaia belangeri 94.36 0.00e+00 1184.00
IUUC-Ttr-128406 Tursiops truncatus 93.61 0.00e+00 1402.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved