iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	42.49	6.00e-50	194.00	IUUC-Hsa-046908

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Drosophila melanogaster

Functional Description
(View)

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA and MtnB genes.

Protein Sequence
(Fasta)

MQRDEKLFEL TLDTVLQRLN DLKLAVLSMI QKLELEYETI NWPTFLDNFA IISSHLTGLT 60
KILAKEQCPP LRNRTVLPLL VSMDRDDTLI NITEGRVPVF SHDIVPDYLR TRPDPITEQK 120

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Nucleotide Sequence
(Fasta)

AATAAGCAGA TCCACGGTCA CACTTTCCAC TTTGTGTCCA TCCGACTGAA GTTAAAAATA 60
ATAGTTTAAT TGGGAGTTTC CAAAATGCAG CGCGACGAAA AGCTTTTTGA GCTGACGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR019364--Mediatior_Med8_fun/met

Pfam

PF10232--Med8

Gene Ontology

GO:0016592--C:mediator complex
GO:0001104--F:RNA polymerase II transcription cofactor activity
GO:0051726--P:regulation of cell cycle
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006367--P:transcription initiation from RNA polymerase II promoter

KEGG

dme:Dmel_CG13867

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001562	Ailuropoda melanoleuca	41.33	2.00e-44	171.00
IUUC-Apl-004218	Anas platyrhynchos	40.52	1.00e-43	168.00
IUUC-Aca-005363	Anolis carolinensis	40.43	1.00e-49	189.00
IUUC-Ame-011384	Astyanax mexicanus	40.82	7.00e-49	186.00
IUUC-Bta-012751	Bos taurus	41.24	1.00e-43	169.00
IUUC-Cel-018292	Caenorhabditis elegans	28.43	4.00e-16	77.80
IUUC-Cja-019318	Callithrix jacchus	40.88	5.00e-44	170.00
IUUC-Cfa-020106	Canis familiaris	50.45	6.00e-30	123.00
IUUC-Cpo-022416	Cavia porcellus	41.52	7.00e-40	156.00
IUUC-Csa-023695	Chlorocebus sabaeus	41.54	4.00e-43	167.00
IUUC-Cin-025570	Ciona intestinalis	35.90	4.00e-31	127.00
IUUC-Csv-025808	Ciona savignyi	37.00	1.00e-32	132.00
IUUC-Dre-027606	Danio rerio	43.03	6.00e-37	145.00
IUUC-Dno-029924	Dasypus novemcinctus	41.76	2.00e-40	158.00
IUUC-Dor-030115	Dipodomys ordii	41.30	3.00e-44	171.00
IUUC-Eca-034101	Equus caballus	41.91	3.00e-45	174.00
IUUC-Eeu-034655	Erinaceus europaeus	37.96	1.00e-36	145.00
IUUC-Fca-036172	Felis catus	41.54	2.00e-44	171.00
IUUC-Fal-036877	Ficedula albicollis	42.34	2.00e-47	181.00
IUUC-Gmo-039244	Gadus morhua	41.27	6.00e-48	182.00
IUUC-Gga-040751	Gallus gallus	41.45	3.00e-44	170.00
IUUC-Gac-041885	Gasterosteus aculeatus	40.07	1.00e-47	182.00
IUUC-Ggo-045201	Gorilla gorilla	41.54	1.00e-43	169.00
IUUC-Hsa-046908	Homo sapiens	41.54	1.00e-43	169.00
IUUC-Itr-048814	Ictidomys tridecemlineatus	41.70	2.00e-44	171.00
IUUC-Lch-049994	Latimeria chalumnae	39.66	8.00e-27	112.00
IUUC-Loc-051765	Lepisosteus oculatus	42.80	5.00e-51	193.00
IUUC-Laf-053336	Loxodonta africana	40.88	1.00e-43	168.00
IUUC-Mcc-055259	Macaca mulatta	41.54	2.00e-43	168.00
IUUC-Meu-056166	Macropus eugenii	38.81	7.00e-41	159.00
IUUC-Mga-059317	Meleagris gallopavo	40.59	6.00e-43	166.00
IUUC-Mmr-061501	Microcebus murinus	41.54	3.00e-44	171.00
IUUC-Mdo-062026	Monodelphis domestica	40.88	9.00e-45	172.00
IUUC-Mmu-063469	Mus musculus	40.88	4.00e-45	173.00
IUUC-Mpu-065945	Mustela putorius furo	41.54	1.00e-44	172.00
IUUC-Mlu-067414	Myotis lucifugus	40.22	9.00e-44	169.00
IUUC-Nle-069411	Nomascus leucogenys	41.61	1.00e-43	169.00
IUUC-Opr-070733	Ochotona princeps	43.01	5.00e-45	173.00
IUUC-Ont-071344	Oreochromis niloticus	39.78	4.00e-48	183.00
IUUC-Oan-073366	Ornithorhynchus anatinus	46.27	2.00e-43	168.00
IUUC-Ocu-074762	Oryctolagus cuniculus	39.50	7.00e-44	169.00
IUUC-Ola-086874	Oryzias latipes	38.99	1.00e-45	175.00
IUUC-Oga-088187	Otolemur garnettii	42.16	8.00e-45	172.00
IUUC-Oar-089832	Ovis aries	40.96	4.00e-43	167.00
IUUC-Ptr-091178	Pan troglodytes	41.91	3.00e-44	171.00
IUUC-Pan-092520	Papio anubis	41.54	1.00e-43	169.00
IUUC-Psi-093517	Pelodiscus sinensis	41.24	3.00e-44	171.00
IUUC-Pma-094752	Petromyzon marinus	43.01	4.00e-57	213.00
IUUC-Pno-094795	Phaeosphaeria nodorum	22.45	4.40e+00	26.20
IUUC-Pfo-096659	Poecilia formosa	38.63	9.00e-45	172.00
IUUC-Pca-101064	Procavia capensis	40.22	2.00e-39	154.00
IUUC-Pva-102173	Pteropus vampyrus	41.70	4.00e-45	174.00
IUUC-Pyt-104747	Pyrenophora triticirepentis	26.87	1.90e-01	25.80
IUUC-Sar-113363	Sorex araneus	40.00	7.00e-41	159.00
IUUC-Ssc-115563	Sus scrofa	42.65	4.00e-50	190.00
IUUC-Tgu-116686	Taeniopygia guttata	42.49	3.00e-47	181.00
IUUC-Tru-118003	Takifugu rubripes	40.60	8.00e-46	176.00
IUUC-Tsy-118875	Tarsius syrichta	37.55	2.00e-37	148.00
IUUC-Tni-120624	Tetraodon nigroviridis	45.08	2.00e-43	168.00
IUUC-Tbe-127611	Tupaia belangeri	46.36	1.00e-33	135.00
IUUC-Ttr-129198	Tursiops truncatus	43.01	1.00e-50	192.00
IUUC-Vpa-130245	Vicugna pacos	44.74	1.00e-03	36.60
IUUC-Xtr-132397	Xenopus tropicalis	43.59	1.00e-54	205.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence