iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065757

Ensembl Protein ID

ENSMPUP00000010404.1

UniProt Accession

M3YGE7; M3YGE7_MUSPF

Genbank Protein ID

ENSMPUP00000010404

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AEYP01034433

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000010481.1	ENSMPUT00000010572.1	ENSMPUP00000010404.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	91.79	0.00e+00	971.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mustela putorius furo

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKAS GMALLHQIQG TELEPLNRPQ LKIPLERPLG EVYVDSSKPA VYNYPEGGAY 60
DFNAAPAASA PVYGQSGLSY GPGSEAAAFG ANGLGGFQPL NSVSPSPLVL LHPPPQLSPF 120

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Nucleotide Sequence
(Fasta)

GTGGCCGCTC GGCTGCTGAG CCCTCTGCCC GGAGGGGAGA CAGTGCGCAC CTTGCCCGCG 60
GCCACTGACC ATGACCATGA CCCTCCACAC GAAAGCGTCC GGAATGGCCC TGCTGCATCA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	96.67	0.00e+00	825.00
IUUC-Apl-003688	Anas platyrhynchos	81.04	0.00e+00	833.00
IUUC-Aca-005222	Anolis carolinensis	78.78	0.00e+00	896.00
IUUC-Ame-010731	Astyanax mexicanus	57.89	4.00e-139	488.00
IUUC-Bta-013112	Bos taurus	89.80	0.00e+00	961.00
IUUC-Cja-019408	Callithrix jacchus	92.63	0.00e+00	1016.00
IUUC-Cfa-020694	Canis familiaris	92.81	0.00e+00	998.00
IUUC-Cpo-021426	Cavia porcellus	85.62	0.00e+00	931.00
IUUC-Cre-022648	Chlamydomonas reinhardtii	30.23	2.50e+00	26.60
IUUC-Csa-023736	Chlorocebus sabaeus	93.25	0.00e+00	884.00
IUUC-Dre-027698	Danio rerio	57.20	4.00e-135	474.00
IUUC-Dno-029477	Dasypus novemcinctus	89.85	0.00e+00	766.00
IUUC-Dor-030572	Dipodomys ordii	90.36	0.00e+00	749.00
IUUC-Ete-032849	Echinops telfairi	72.27	0.00e+00	670.00
IUUC-Eca-033605	Equus caballus	86.93	0.00e+00	966.00
IUUC-Eeu-034683	Erinaceus europaeus	90.65	2.00e-108	385.00
IUUC-Fca-035928	Felis catus	95.32	0.00e+00	814.00
IUUC-Fal-036754	Ficedula albicollis	78.26	0.00e+00	911.00
IUUC-Gmo-038872	Gadus morhua	60.42	2.00e-113	402.00
IUUC-Gga-040988	Gallus gallus	79.26	0.00e+00	902.00
IUUC-Gac-042015	Gasterosteus aculeatus	64.72	2.00e-126	446.00
IUUC-Ggo-044749	Gorilla gorilla	92.46	0.00e+00	1015.00
IUUC-Hsa-046944	Homo sapiens	91.79	0.00e+00	1006.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	90.82	0.00e+00	993.00
IUUC-Loc-052414	Lepisosteus oculatus	59.93	0.00e+00	651.00
IUUC-Mcc-054781	Macaca mulatta	92.63	0.00e+00	1016.00
IUUC-Meu-056232	Macropus eugenii	86.77	0.00e+00	954.00
IUUC-Mga-059319	Meleagris gallopavo	79.60	0.00e+00	905.00
IUUC-Mmr-061636	Microcebus murinus	92.39	2.00e-176	611.00
IUUC-Mdo-062661	Monodelphis domestica	87.27	0.00e+00	963.00
IUUC-Mmu-063330	Mus musculus	88.85	0.00e+00	944.00
IUUC-Mlu-067712	Myotis lucifugus	91.11	0.00e+00	863.00
IUUC-Nle-069283	Nomascus leucogenys	92.46	0.00e+00	972.00
IUUC-Opr-070391	Ochotona princeps	87.63	0.00e+00	983.00
IUUC-Ont-071369	Oreochromis niloticus	51.45	5.00e-122	431.00
IUUC-Oan-073734	Ornithorhynchus anatinus	74.20	2.00e-134	471.00
IUUC-Ocu-074292	Oryctolagus cuniculus	90.52	0.00e+00	984.00
IUUC-Oba-075103	Oryza barthii	28.21	4.00e-03	36.20
IUUC-Ogu-079042	Oryza glumaepatula	28.21	7.00e-04	38.90
IUUC-Olo-080944	Oryza longistaminata	28.21	2.00e-03	35.80
IUUC-Oni-082560	Oryza nivara	28.21	3.00e-03	36.60
IUUC-Ola-087052	Oryzias latipes	51.58	8.00e-132	464.00
IUUC-Oga-088586	Otolemur garnettii	91.67	0.00e+00	992.00
IUUC-Oar-090156	Ovis aries	91.98	0.00e+00	824.00
IUUC-Ptr-091321	Pan troglodytes	92.63	0.00e+00	1016.00
IUUC-Pan-092851	Papio anubis	92.46	0.00e+00	1014.00
IUUC-Psi-093434	Pelodiscus sinensis	78.43	0.00e+00	936.00
IUUC-Pfo-097379	Poecilia formosa	57.39	3.00e-134	472.00
IUUC-Pab-097735	Pongo abelii	92.46	0.00e+00	1014.00
IUUC-Pva-102125	Pteropus vampyrus	88.94	0.00e+00	978.00
IUUC-Rno-106121	Rattus norvegicus	88.87	0.00e+00	944.00
IUUC-Sha-107547	Sarcophilus harrisii	87.27	0.00e+00	959.00
IUUC-Sar-113650	Sorex araneus	79.71	0.00e+00	638.00
IUUC-Tgu-117175	Taeniopygia guttata	79.69	0.00e+00	911.00
IUUC-Tru-117545	Takifugu rubripes	51.61	5.00e-138	485.00
IUUC-Tsy-119586	Tarsius syrichta	78.09	0.00e+00	843.00
IUUC-Tni-120121	Tetraodon nigroviridis	51.56	3.00e-139	488.00
IUUC-Tbe-127548	Tupaia belangeri	82.06	0.00e+00	639.00
IUUC-Ttr-128374	Tursiops truncatus	87.77	0.00e+00	883.00
IUUC-Vpa-130464	Vicugna pacos	82.24	1.00e-155	542.00
IUUC-Xtr-132171	Xenopus tropicalis	70.18	0.00e+00	756.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence