iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013223

Ensembl Protein ID

ENSBTAP00000012281.5

UniProt Accession

F1MCC8; F1MCC8_BOVIN

Genbank Protein ID

ENSBTAP00000012281

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02019086

Gene Name

NWD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000009328.6	ENSBTAT00000012281.5	ENSBTAP00000012281.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-27	93.5	702	736
UBD/Beta-Prp	1.20e-54	185.7	656	871

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcla.f.sdtllvsGsdDgtikvWDlrtg 33
           gHt++v+c++ f ++t+ vs+s D t+++WDl +g
   Q: 702  GHTGEVRCVEvFaQGTHAVSASKDQTLRLWDLLSG 736
           8********977988****************9776 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee... 131
           ++lsg+ +++ta+ +s ++k+l+ g + +++ vwd++  + +h+l gh+ +v++++++++g + vs+s+d+t+r+wdl +gq+  +   
   Q: 656  ATLSGCHKGITAMAWSLEEKLLLVGTQEGMVAVWDMEEQQVIHILPGHTGEVRCVEVFAQGTHAVSASKDQTLRLWDLLSGQEKFTiwd 744
           79**********************************************************************************999** PP
   S: 132  ..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtl 218
              ++++++ +++++v++ ++++ s+s  +++  W+l+t++l+ +  g+  d+  ++++  ++  l+++s+ g + lw+  tg+  r++
   Q: 745  ggSKDPTESQTWSLHVDEAKKVVYSAS-GSKISAWNLETAELIFRILGDASDPWVCMAVLASQATLLTVSQGGVISLWSSATGTLHRRQ 832
           **9***************766666655.578999***********************************************99997766 PP
   S: 219  nght....dnvksvrfspnderlvsgssDgsiriWdlrsg 254
           +  +    +  + v + ++   +v+gss gsi++  ++ +
   Q: 833  RLSSvkedTLACGVSV-QKRGMMVTGSSTGSISLVSSEGD 871
           6544444233333444.69999*********998655555 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MVDRLADGCL DTDAQHLLSN LKGRIADRQP GVLKAHHLAW SRDLVNPKNK AHARYLKELG 60
EQFVARANHQ VLECLRELEA GRQELAWLYQ EIRHHLGLSA EVNRTFCGRQ ELLTQLGQRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTGTGCCC TCAGAATGGT GGACCGTCTT GCAGATGGTT GCCTGGACAC GGATGCCCAG 60
CACCTTCTCA GCAACCTCAA GGGGCGCATC GCTGACCGGC AGCCTGGAGT TCTCAAGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0008380--P:RNA splicing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001525	Ailuropoda melanoleuca	86.23	0.00e+00	2310.00
IUUC-Apl-003467	Anas platyrhynchos	61.57	5.00e-81	293.00
IUUC-Ame-011400	Astyanax mexicanus	36.49	0.00e+00	839.00
IUUC-Cel-018404	Caenorhabditis elegans	28.55	8.00e-74	273.00
IUUC-Cja-018773	Callithrix jacchus	80.51	0.00e+00	1534.00
IUUC-Cfa-020334	Canis familiaris	86.77	0.00e+00	2323.00
IUUC-Cpo-022316	Cavia porcellus	65.64	0.00e+00	1667.00
IUUC-Csa-023631	Chlorocebus sabaeus	82.77	0.00e+00	2212.00
IUUC-Cin-025646	Ciona intestinalis	33.60	4.00e-140	492.00
IUUC-Csv-026191	Ciona savignyi	25.44	3.00e-26	112.00
IUUC-Dre-028241	Danio rerio	36.17	0.00e+00	810.00
IUUC-Dno-029990	Dasypus novemcinctus	80.63	0.00e+00	704.00
IUUC-Dor-030869	Dipodomys ordii	57.06	7.00e-177	614.00
IUUC-Ete-033059	Echinops telfairi	82.24	0.00e+00	838.00
IUUC-Eca-033718	Equus caballus	82.25	0.00e+00	2216.00
IUUC-Fca-035748	Felis catus	84.63	0.00e+00	2129.00
IUUC-Gac-041507	Gasterosteus aculeatus	35.54	0.00e+00	644.00
IUUC-Ggo-044551	Gorilla gorilla	80.76	0.00e+00	2163.00
IUUC-Hsa-046787	Homo sapiens	82.18	0.00e+00	2217.00
IUUC-Itr-048104	Ictidomys tridecemlineatus	60.71	0.00e+00	1452.00
IUUC-Kpa-049302	Komagataella pastoris	39.71	5.00e-10	60.10
IUUC-Lch-049578	Latimeria chalumnae	48.42	0.00e+00	1291.00
IUUC-Loc-052039	Lepisosteus oculatus	41.89	0.00e+00	1070.00
IUUC-Laf-054240	Loxodonta africana	82.19	0.00e+00	2276.00
IUUC-Mcc-054657	Macaca mulatta	74.76	0.00e+00	1935.00
IUUC-Meu-056591	Macropus eugenii	62.68	0.00e+00	1147.00
IUUC-Mmr-061577	Microcebus murinus	78.70	0.00e+00	2115.00
IUUC-Mdo-062895	Monodelphis domestica	62.53	0.00e+00	1572.00
IUUC-Mmu-063866	Mus musculus	76.44	0.00e+00	2052.00
IUUC-Mpu-066510	Mustela putorius furo	85.35	0.00e+00	2331.00
IUUC-Mlu-067855	Myotis lucifugus	85.49	0.00e+00	2257.00
IUUC-Nle-069557	Nomascus leucogenys	77.48	0.00e+00	2007.00
IUUC-Opr-071196	Ochotona princeps	62.11	1.00e-113	405.00
IUUC-Ont-072070	Oreochromis niloticus	34.84	0.00e+00	692.00
IUUC-Oan-073437	Ornithorhynchus anatinus	58.48	0.00e+00	1066.00
IUUC-Ocu-074941	Oryctolagus cuniculus	82.73	6.00e-52	196.00
IUUC-Ola-086624	Oryzias latipes	33.48	0.00e+00	711.00
IUUC-Oga-088313	Otolemur garnettii	83.01	0.00e+00	2004.00
IUUC-Oar-090123	Ovis aries	95.80	0.00e+00	2577.00
IUUC-Ptr-090552	Pan troglodytes	81.50	0.00e+00	1076.00
IUUC-Psi-093963	Pelodiscus sinensis	55.54	0.00e+00	1432.00
IUUC-Pfo-096197	Poecilia formosa	33.93	0.00e+00	712.00
IUUC-Pab-097755	Pongo abelii	79.46	0.00e+00	901.00
IUUC-Pca-100809	Procavia capensis	78.21	0.00e+00	1210.00
IUUC-Pva-102554	Pteropus vampyrus	83.14	0.00e+00	1959.00
IUUC-Rno-105174	Rattus norvegicus	71.65	0.00e+00	1869.00
IUUC-Sha-107304	Sarcophilus harrisii	62.09	0.00e+00	1727.00
IUUC-Sar-113168	Sorex araneus	65.64	0.00e+00	1150.00
IUUC-Tru-118251	Takifugu rubripes	35.05	1.00e-165	577.00
IUUC-Tsy-119276	Tarsius syrichta	79.35	2.00e-119	424.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence