iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092909

Ensembl Protein ID

ENSPANP00000004285.1

UniProt Accession

A0A096MWM7; A0A096MWM7_PAPAN

Genbank Protein ID

ENSPANP00000004285

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AHZZ01017236

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000016830.1	ENSPANT00000007849.1	ENSPANP00000004285.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.10e-64	218.0	2	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           ++ ++e +P++++++++++gv +++++ ++ +L++e+lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq+i
   Q: 2    QLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTI 86
           5789*************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           gNsC+t++l+++++n++dkl ++ G+ l++++++t+++spe++a++++++++++++h+++a++++++ +          +k +fhf+++
   Q: 87   GNSCGTIGLIHAVANNQDKLgFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVD----------DKVNFHFILF 165
           *******************************************************************99..........5679****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
            n++g+lyeldg++pfP+++g+++e + l+d++kv+r+f+er    e++e+rf+++a++++
   Q: 166  NNVDGHLYELDGRMPFPVNHGASSEGTLLQDAAKVCREFTER----EQGEVRFSAVALCKA 222
           ******************************************....************987 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGAAA GGATGGGTTT CCAGAAACTT CGCCCAAAAT TAAAGACTCC ATCAAAAGGA 60
CTGCTCCATA CACTCAAGGA ACACCCACCA ACAAATCCCG TCTCCACAAC CACCAGATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	80.08	4.00e-112	397.00
IUUC-Apl-003693	Anas platyrhynchos	68.75	3.00e-90	324.00
IUUC-Aca-004716	Anolis carolinensis	76.79	6.00e-102	362.00
IUUC-Ame-011806	Astyanax mexicanus	68.16	2.00e-85	308.00
IUUC-Bta-013521	Bos taurus	81.75	3.00e-114	404.00
IUUC-Cja-018752	Callithrix jacchus	98.66	2.00e-119	421.00
IUUC-Cfa-020442	Canis familiaris	95.54	5.00e-116	409.00
IUUC-Cpo-021723	Cavia porcellus	96.99	6.00e-94	335.00
IUUC-Csa-023626	Chlorocebus sabaeus	100.00	4.00e-122	429.00
IUUC-Cho-024548	Choloepus hoffmanni	85.19	3.00e-40	157.00
IUUC-Dre-027854	Danio rerio	65.62	6.00e-84	303.00
IUUC-Dno-029325	Dasypus novemcinctus	95.96	1.00e-117	415.00
IUUC-Dor-030114	Dipodomys ordii	94.62	3.00e-126	443.00
IUUC-Ete-033092	Echinops telfairi	77.58	8.00e-97	345.00
IUUC-Eca-033854	Equus caballus	96.48	5.00e-79	285.00
IUUC-Eeu-034493	Erinaceus europaeus	93.27	3.00e-113	400.00
IUUC-Fal-036693	Ficedula albicollis	73.33	1.00e-91	328.00
IUUC-Gmo-038848	Gadus morhua	61.32	1.00e-74	272.00
IUUC-Gga-041078	Gallus gallus	74.11	2.00e-100	357.00
IUUC-Gac-042064	Gasterosteus aculeatus	61.82	4.00e-77	280.00
IUUC-Ggo-044827	Gorilla gorilla	99.10	8.00e-121	425.00
IUUC-Hsa-045820	Homo sapiens	99.10	8.00e-121	425.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	96.86	1.00e-118	418.00
IUUC-Lch-050121	Latimeria chalumnae	74.32	4.00e-98	350.00
IUUC-Loc-052342	Lepisosteus oculatus	69.91	7.00e-92	329.00
IUUC-Laf-053916	Loxodonta africana	94.22	3.00e-115	407.00
IUUC-Mcc-054838	Macaca mulatta	100.00	4.00e-122	429.00
IUUC-Meu-056478	Macropus eugenii	88.34	4.00e-120	423.00
IUUC-Mga-059878	Meleagris gallopavo	72.81	2.00e-94	337.00
IUUC-Mdo-062544	Monodelphis domestica	87.44	4.00e-109	386.00
IUUC-Mmu-063300	Mus musculus	95.52	6.00e-127	446.00
IUUC-Mpu-066128	Mustela putorius furo	95.00	7.00e-103	366.00
IUUC-Mlu-067778	Myotis lucifugus	94.17	2.00e-125	440.00
IUUC-Nle-069686	Nomascus leucogenys	98.65	2.00e-120	424.00
IUUC-Opr-070535	Ochotona princeps	78.48	7.00e-99	352.00
IUUC-Ont-071510	Oreochromis niloticus	62.61	2.00e-79	288.00
IUUC-Ocu-074590	Oryctolagus cuniculus	96.41	4.00e-118	416.00
IUUC-Ola-087552	Oryzias latipes	59.21	2.00e-74	271.00
IUUC-Oga-089013	Otolemur garnettii	82.14	2.00e-113	401.00
IUUC-Oar-089861	Ovis aries	81.75	2.00e-114	404.00
IUUC-Ptr-091536	Pan troglodytes	97.31	2.00e-118	417.00
IUUC-Psi-093818	Pelodiscus sinensis	79.02	1.00e-103	368.00
IUUC-Pfo-097335	Poecilia formosa	60.44	8.00e-79	286.00
IUUC-Pab-098048	Pongo abelii	99.10	8.00e-121	425.00
IUUC-Pca-100818	Procavia capensis	72.31	4.00e-66	243.00
IUUC-Pva-102954	Pteropus vampyrus	95.07	1.00e-112	398.00
IUUC-Rno-105966	Rattus norvegicus	95.52	6.00e-127	446.00
IUUC-Sha-107111	Sarcophilus harrisii	86.06	4.00e-86	309.00
IUUC-Sar-113190	Sorex araneus	73.68	2.00e-38	150.00
IUUC-Ssc-115908	Sus scrofa	78.67	2.00e-99	355.00
IUUC-Tgu-117465	Taeniopygia guttata	69.19	3.00e-85	307.00
IUUC-Tru-118565	Takifugu rubripes	60.78	1.00e-69	255.00
IUUC-Tsy-119561	Tarsius syrichta	78.48	5.00e-98	349.00
IUUC-Tbe-128048	Tupaia belangeri	95.15	3.00e-92	330.00
IUUC-Ttr-128494	Tursiops truncatus	95.95	1.00e-115	408.00
IUUC-Vda-129850	Verticillium dahliae	33.77	5.00e-28	117.00
IUUC-Xtr-132286	Xenopus tropicalis	69.51	5.00e-92	330.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence