iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011432

Ensembl Protein ID

ENSAMXP00000005150.1

UniProt Accession

W5KC39; W5KC39_ASTMX

Genbank Protein ID

ENSAMXP00000005150

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

APWO01086999

Gene Name

wdr12; WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000005026.1	ENSAMXT00000005150.1	ENSAMXP00000005150.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-41	138.8	340	375
UBD/Beta-Prp	4.20e-45	154.4	245	411

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  s+ + lvsGs D+ +k+WD+r+++
   Q: 340  HTGWVTAVRWslSNnHQLVSGSFDNMVKLWDIRSCK 375
           ************55599**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh + v s+ +    + l s+s+d tir+wd etg   + +l+g + v nc++++p ++ l+sGs+Dr vrlWd ++++ 
   Q: 245  TRTPLMTLSGHGEAVSSVLWTD-AEELCSASWDHTIRLWDAETGGQKS-MLTGSK-VFNCISYSPLCRRLASGSTDRHVRLWDPRSKDG 330
           67899***************99.999*********************9.999987.99**************************76654 PP
   S: 172  lrtl...tgghtdsvyslsfd.sngkelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ v+ + ++ sn  +lvsgs d+ vklwd++  +  ++ l +h+d v + + + ++ +++sg++D+ ++ +
   Q: 331  SLVLlslTS-HTGWVTAVRWSlSNNHQLVSGSFDNMVKLWDIRsCKAPLYDLAAHEDRVMCADWT-ESGLILSGGADNKLYTY 411
           333334387.*********77356699****************54566***************99.99*********999876 PP

Organism

Astyanax mexicanus

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQLQARFFT EYKKFAIDDV PFSIPAASEV TDLSNVINKL LEFKIADHKH VEFDFLVRGQ 60
FLRTSLANHM ETENISTEEV VEIEYVQKFT APQPEECIMH DDWISSVEAD SEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCAGTAAT CCTGTGCAAT AGCGGTGTGT GTTCTGTGAT CGATTGCTGC TGTCTGCACA 60
TTAGAGCACA TGGTGTTAGA GCAGTGCTCG GTGTAGATCC GGAGCGCCGC TGATCACATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.25	7.00e-64	237.00
IUUC-Aml-001997	Ailuropoda melanoleuca	76.46	1.00e-174	605.00
IUUC-Atr-002544	Amborella trichopoda	32.86	1.00e-57	216.00
IUUC-Apl-003981	Anas platyrhynchos	79.89	2.00e-172	598.00
IUUC-Aca-004370	Anolis carolinensis	75.06	0.00e+00	668.00
IUUC-Aly-006455	Arabidopsis lyrata	33.25	2.00e-61	229.00
IUUC-Ath-006669	Arabidopsis thaliana	32.70	2.00e-57	216.00
IUUC-Ago-007864	Ashbya gossypii	29.64	2.00e-40	159.00
IUUC-Acl-008177	Aspergillus clavatus	28.22	7.00e-39	154.00
IUUC-Afl-008617	Aspergillus flavus	28.29	2.00e-38	153.00
IUUC-Afu-008752	Aspergillus fumigatus	27.80	3.00e-36	146.00
IUUC-Ani-009136	Aspergillus nidulans	28.28	4.00e-38	152.00
IUUC-Ang-009701	Aspergillus niger	28.46	2.00e-36	146.00
IUUC-Aor-009884	Aspergillus oryzae	28.05	5.00e-38	152.00
IUUC-Bgr-012218	Blumeria graminis	29.50	2.00e-36	146.00
IUUC-Bta-012829	Bos taurus	76.60	0.00e+00	626.00
IUUC-Bci-013953	Botrytis cinerea	28.64	1.00e-38	154.00
IUUC-Bdi-014351	Brachypodium distachyon	34.60	2.00e-59	223.00
IUUC-Bol-016190	Brassica oleracea	34.03	3.00e-59	222.00
IUUC-Bra-018095	Brassica rapa	34.03	2.00e-59	223.00
IUUC-Cel-018569	Caenorhabditis elegans	33.17	2.00e-52	199.00
IUUC-Cja-019468	Callithrix jacchus	75.89	4.00e-174	603.00
IUUC-Cfa-020471	Canis familiaris	77.07	3.00e-178	617.00
IUUC-Cpo-022260	Cavia porcellus	75.41	3.00e-175	607.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	32.15	2.00e-43	169.00
IUUC-Csa-023989	Chlorocebus sabaeus	75.65	1.00e-174	605.00
IUUC-Cho-024426	Choloepus hoffmanni	76.51	9.00e-131	459.00
IUUC-Cin-025789	Ciona intestinalis	43.16	1.00e-101	363.00
IUUC-Cne-027063	Cryptococcus neoformans	23.66	4.00e-13	69.30
IUUC-Dre-027907	Danio rerio	90.76	0.00e+00	765.00
IUUC-Dno-029225	Dasypus novemcinctus	75.18	2.00e-178	618.00
IUUC-Dor-031082	Dipodomys ordii	63.12	5.00e-132	464.00
IUUC-Dse-031308	Dothistroma septosporum	28.57	2.00e-38	152.00
IUUC-Dme-032189	Drosophila melanogaster	40.24	7.00e-94	337.00
IUUC-Ete-032247	Echinops telfairi	72.58	1.00e-164	572.00
IUUC-Eca-034285	Equus caballus	76.83	0.00e+00	628.00
IUUC-Eeu-035322	Erinaceus europaeus	71.11	5.00e-153	533.00
IUUC-Fca-036114	Felis catus	76.36	2.00e-180	624.00
IUUC-Fal-036891	Ficedula albicollis	80.23	3.00e-160	557.00
IUUC-Fox-037965	Fusarium oxysporum	25.05	4.00e-37	149.00
IUUC-Fso-038244	Fusarium solani	25.48	5.00e-36	145.00
IUUC-Gmo-039040	Gadus morhua	83.45	0.00e+00	714.00
IUUC-Ggr-040093	Gaeumannomyces graminis	25.11	6.00e-14	72.40
IUUC-Gga-040610	Gallus gallus	77.78	0.00e+00	659.00
IUUC-Gac-042117	Gasterosteus aculeatus	82.03	0.00e+00	687.00
IUUC-Gma-043146	Glycine max	36.14	1.00e-67	250.00
IUUC-Ggo-045179	Gorilla gorilla	76.60	9.00e-176	609.00
IUUC-Hsa-046114	Homo sapiens	76.12	2.00e-174	605.00
IUUC-Hvu-047331	Hordeum vulgare	33.85	9.00e-59	220.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	75.41	5.00e-179	620.00
IUUC-Kpa-049304	Komagataella pastoris	29.91	4.00e-43	169.00
IUUC-Lch-050655	Latimeria chalumnae	74.63	9.00e-140	489.00
IUUC-Lpe-051675	Leersia perrieri	34.13	7.00e-62	231.00
IUUC-Loc-052868	Lepisosteus oculatus	82.27	0.00e+00	695.00
IUUC-Lma-053258	Leptosphaeria maculans	26.78	3.00e-35	144.00
IUUC-Laf-053993	Loxodonta africana	77.54	4.00e-180	624.00
IUUC-Mcc-055128	Macaca mulatta	62.65	4.00e-136	477.00
IUUC-Meu-056501	Macropus eugenii	67.29	4.00e-137	480.00
IUUC-Mor-057114	Magnaporthe oryzae	26.85	6.00e-30	125.00
IUUC-Mtr-058367	Medicago truncatula	36.54	8.00e-65	241.00
IUUC-Mla-059107	Melampsora laricipopulina	25.92	1.00e-31	130.00
IUUC-Mga-059745	Meleagris gallopavo	76.79	0.00e+00	635.00
IUUC-Mvi-060362	Microbotryum violaceum	32.97	9.00e-21	94.70
IUUC-Mdo-062257	Monodelphis domestica	74.35	0.00e+00	640.00
IUUC-Mmu-063546	Mus musculus	76.60	2.00e-180	625.00
IUUC-Mac-065540	Musa acuminata	32.30	1.00e-61	230.00
IUUC-Mpu-066284	Mustela putorius furo	75.89	8.00e-180	623.00
IUUC-Mlu-067241	Myotis lucifugus	76.36	8.00e-180	622.00
IUUC-Nfi-068260	Neosartorya fischeri	28.05	4.00e-37	149.00
IUUC-Ncr-068719	Neurospora crassa	25.42	4.00e-27	115.00
IUUC-Nle-068981	Nomascus leucogenys	76.36	6.00e-174	603.00
IUUC-Opr-071218	Ochotona princeps	71.11	1.00e-162	565.00
IUUC-Ont-071646	Oreochromis niloticus	82.90	0.00e+00	684.00
IUUC-Oan-073453	Ornithorhynchus anatinus	77.30	0.00e+00	689.00
IUUC-Ocu-074008	Oryctolagus cuniculus	76.60	0.00e+00	628.00
IUUC-Oba-075712	Oryza barthii	30.05	1.00e-46	181.00
IUUC-Obr-076721	Oryza brachyantha	33.65	6.00e-62	231.00
IUUC-Ogl-077229	Oryza glaberrima	34.61	2.00e-63	236.00
IUUC-Ogu-078977	Oryza glumaepatula	29.81	5.00e-47	181.00
IUUC-Oin-079683	Oryza indica	34.61	8.00e-64	237.00
IUUC-Olo-080291	Oryza longistaminata	29.39	1.00e-30	126.00
IUUC-Ome-081834	Oryza meridionalis	35.08	8.00e-65	241.00
IUUC-Oni-082507	Oryza nivara	33.01	4.00e-59	221.00
IUUC-Opu-083396	Oryza punctata	33.89	1.00e-62	233.00
IUUC-Oru-085220	Oryza rufipogon	32.85	2.00e-58	219.00
IUUC-Osa-085767	Oryza sativa	34.61	8.00e-64	237.00
IUUC-Ola-087420	Oryzias latipes	81.56	0.00e+00	706.00
IUUC-Olu-087740	Ostreococcus lucimarinus	27.88	9.00e-40	157.00
IUUC-Oga-088264	Otolemur garnettii	76.36	1.00e-178	619.00
IUUC-Oar-089335	Ovis aries	76.12	1.00e-179	622.00
IUUC-Ptr-091320	Pan troglodytes	76.12	2.00e-174	605.00
IUUC-Pan-092833	Papio anubis	75.18	3.00e-173	600.00
IUUC-Psi-093504	Pelodiscus sinensis	78.01	0.00e+00	660.00
IUUC-Pma-094189	Petromyzon marinus	67.22	2.00e-165	574.00
IUUC-Pno-094929	Phaeosphaeria nodorum	26.11	4.00e-35	142.00
IUUC-Ppa-095429	Physcomitrella patens	35.29	2.00e-66	246.00
IUUC-Pfo-096337	Poecilia formosa	82.27	0.00e+00	708.00
IUUC-Pab-097571	Pongo abelii	76.36	2.00e-174	605.00
IUUC-Pop-099977	Populus trichocarpa	33.98	3.00e-66	245.00
IUUC-Pca-100394	Procavia capensis	73.84	7.00e-162	563.00
IUUC-Ppe-101848	Prunus persica	35.71	4.00e-66	245.00
IUUC-Pva-102921	Pteropus vampyrus	77.33	3.00e-94	338.00
IUUC-Pgr-103637	Puccinia graminis	26.92	6.00e-40	158.00
IUUC-Ptt-103781	Puccinia triticina	27.10	3.00e-38	152.00
IUUC-Pte-104135	Pyrenophora teres	27.27	3.00e-34	140.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	26.01	1.00e-33	137.00
IUUC-Rno-105114	Rattus norvegicus	77.07	0.00e+00	627.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.26	3.00e-41	162.00
IUUC-Sha-107122	Sarcophilus harrisii	74.70	3.00e-174	604.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.58	1.00e-50	193.00
IUUC-Spo-108134	Schizosaccharomyces pombe	28.97	4.00e-43	169.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	29.16	1.00e-40	160.00
IUUC-Smo-108720	Selaginella moellendorffii	33.33	2.00e-60	226.00
IUUC-Sit-110311	Setaria italica	35.13	2.00e-62	233.00
IUUC-Sly-111178	Solanum lycopersicum	34.00	3.00e-62	232.00
IUUC-Stu-112778	Solanum tuberosum	35.89	3.00e-67	248.00
IUUC-Sar-113596	Sorex araneus	62.88	2.00e-136	479.00
IUUC-Sbi-114193	Sorghum bicolor	35.99	2.00e-62	233.00
IUUC-Sre-115002	Sporisorium reilianum	27.54	1.00e-17	84.70
IUUC-Ssc-116066	Sus scrofa	75.65	2.00e-178	618.00
IUUC-Tgu-117048	Taeniopygia guttata	78.84	1.00e-170	592.00
IUUC-Tsy-119573	Tarsius syrichta	49.64	3.00e-106	378.00
IUUC-Tni-119820	Tetraodon nigroviridis	79.20	0.00e+00	664.00
IUUC-Tca-121605	Theobroma cacao	34.70	2.00e-66	246.00
IUUC-Tre-121947	Trichoderma reesei	26.39	7.00e-36	144.00
IUUC-Tvi-122481	Trichoderma virens	26.61	2.00e-37	150.00
IUUC-Tae-125861	Triticum aestivum	33.49	5.00e-64	238.00
IUUC-Tur-126586	Triticum urartu	34.10	4.00e-61	228.00
IUUC-Tme-126900	Tuber melanosporum	30.50	1.00e-48	187.00
IUUC-Tbe-127736	Tupaia belangeri	57.04	2.00e-117	415.00
IUUC-Ttr-129041	Tursiops truncatus	66.19	5.00e-154	537.00
IUUC-Uma-129628	Ustilago maydis	27.19	3.00e-11	63.20
IUUC-Vpa-130260	Vicugna pacos	76.36	1.00e-180	625.00
IUUC-Vvi-131009	Vitis vinifera	35.08	1.00e-65	243.00
IUUC-Xtr-132083	Xenopus tropicalis	74.00	0.00e+00	629.00
IUUC-Xma-133094	Xiphophorus maculatus	82.51	0.00e+00	704.00
IUUC-Yli-134531	Yarrowia lipolytica	23.25	5.00e-22	99.00
IUUC-Zma-135509	Zea mays	33.57	2.00e-62	232.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence