iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093338

Ensembl Protein ID

ENSPSIP00000012863.1

UniProt Accession

K7FXV3; K7FXV3_PELSI

Genbank Protein ID

ENSPSIP00000012863

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGCU01018617

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000011454.1	ENSPSIT00000012924.1	ENSPSIP00000012863.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.50e-135	450.4	586	918

Active Site

Position(s)	Description	Evidence
887	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 586  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 673
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee++l++ f+v+ e+lg+++++eLk+gG+ni+Vt+eNkeeY+ l++e
   Q: 674  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECNLEMYFCVDMELLGKVTSHELKSGGSNIMVTEENKEEYIGLMAE 759
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++ q++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw+++++ ++e r ++LqFv
   Q: 760  WRFSRGVRDQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKDTDNEVRMRLLQFV 847
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 848  TGTCRLPLGGFAELMgsngPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 918
           *********************************************************************96 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MATASPRSDT SNNHNGRLQM QVTVSSAKLK RKKNWFGTAI YTELAADGEI KKTAKSNSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTIKA DALLGKATID LRQALEIHNR KLEGVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGTAAATA CACTTGACTC AGCTCTCCGC CCCTTCCTTT CGCTAGAGAG GTTGGTTCCT 60
TCCCCCTGTA GGGAAGTTGG TTCAGGCCGG GGCCTTTGCC CAGGCGGTAG TAGCTGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

pss:102448686

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	83.64	0.00e+00	1573.00
IUUC-Apl-003310	Anas platyrhynchos	89.41	0.00e+00	1682.00
IUUC-Aca-005388	Anolis carolinensis	85.68	0.00e+00	1573.00
IUUC-Ame-010992	Astyanax mexicanus	91.01	0.00e+00	864.00
IUUC-Bta-012857	Bos taurus	84.51	0.00e+00	1563.00
IUUC-Cel-018299	Caenorhabditis elegans	68.22	0.00e+00	853.00
IUUC-Cja-019448	Callithrix jacchus	84.29	0.00e+00	1589.00
IUUC-Cfa-020728	Canis familiaris	84.40	0.00e+00	1572.00
IUUC-Cpo-021635	Cavia porcellus	80.50	0.00e+00	1535.00
IUUC-Csa-023805	Chlorocebus sabaeus	85.99	0.00e+00	1204.00
IUUC-Cho-024943	Choloepus hoffmanni	73.72	0.00e+00	1040.00
IUUC-Cin-025212	Ciona intestinalis	74.09	0.00e+00	918.00
IUUC-Csv-026256	Ciona savignyi	73.18	0.00e+00	912.00
IUUC-Dre-028245	Danio rerio	72.51	0.00e+00	1262.00
IUUC-Dno-029618	Dasypus novemcinctus	83.64	0.00e+00	1566.00
IUUC-Dor-030176	Dipodomys ordii	79.26	0.00e+00	992.00
IUUC-Dme-032041	Drosophila melanogaster	70.33	0.00e+00	900.00
IUUC-Ete-032779	Echinops telfairi	91.37	0.00e+00	1082.00
IUUC-Eca-033313	Equus caballus	84.18	0.00e+00	1553.00
IUUC-Eeu-035259	Erinaceus europaeus	76.95	0.00e+00	1404.00
IUUC-Fca-035420	Felis catus	83.42	0.00e+00	1570.00
IUUC-Fal-037335	Ficedula albicollis	88.77	0.00e+00	1662.00
IUUC-Gmo-039172	Gadus morhua	88.01	0.00e+00	1074.00
IUUC-Gga-040246	Gallus gallus	89.60	0.00e+00	1670.00
IUUC-Gac-042211	Gasterosteus aculeatus	92.14	0.00e+00	1186.00
IUUC-Ggo-045001	Gorilla gorilla	82.88	0.00e+00	1378.00
IUUC-Hsa-046544	Homo sapiens	83.53	0.00e+00	1579.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	82.83	0.00e+00	1524.00
IUUC-Lch-050398	Latimeria chalumnae	79.87	0.00e+00	1456.00
IUUC-Loc-052116	Lepisosteus oculatus	77.92	0.00e+00	1442.00
IUUC-Laf-053551	Loxodonta africana	83.66	0.00e+00	1543.00
IUUC-Meu-055953	Macropus eugenii	68.33	0.00e+00	859.00
IUUC-Mga-059986	Meleagris gallopavo	89.83	0.00e+00	1686.00
IUUC-Mmr-060945	Microcebus murinus	81.34	0.00e+00	1514.00
IUUC-Mdo-063024	Monodelphis domestica	82.97	0.00e+00	1525.00
IUUC-Mmu-063202	Mus musculus	81.39	0.00e+00	1493.00
IUUC-Mpu-065773	Mustela putorius furo	84.54	0.00e+00	1572.00
IUUC-Mlu-067373	Myotis lucifugus	92.93	0.00e+00	633.00
IUUC-Nle-069188	Nomascus leucogenys	84.07	0.00e+00	1588.00
IUUC-Opr-070965	Ochotona princeps	80.61	0.00e+00	1484.00
IUUC-Ont-072226	Oreochromis niloticus	72.31	0.00e+00	1395.00
IUUC-Oan-073497	Ornithorhynchus anatinus	86.57	0.00e+00	1588.00
IUUC-Ocu-073891	Oryctolagus cuniculus	80.63	0.00e+00	1463.00
IUUC-Ola-087438	Oryzias latipes	90.43	0.00e+00	1191.00
IUUC-Oga-087922	Otolemur garnettii	84.00	0.00e+00	1562.00
IUUC-Oar-089317	Ovis aries	83.55	0.00e+00	1541.00
IUUC-Ptr-090484	Pan troglodytes	83.53	0.00e+00	1578.00
IUUC-Pan-092117	Papio anubis	83.86	0.00e+00	1584.00
IUUC-Pma-094279	Petromyzon marinus	73.74	0.00e+00	840.00
IUUC-Pfo-096171	Poecilia formosa	92.65	0.00e+00	1189.00
IUUC-Pab-098654	Pongo abelii	83.65	0.00e+00	1164.00
IUUC-Pca-100596	Procavia capensis	70.24	0.00e+00	869.00
IUUC-Pva-102811	Pteropus vampyrus	74.70	0.00e+00	1344.00
IUUC-Rno-106125	Rattus norvegicus	81.24	0.00e+00	1514.00
IUUC-Sha-107243	Sarcophilus harrisii	84.71	0.00e+00	1562.00
IUUC-Ssc-115368	Sus scrofa	83.82	0.00e+00	1546.00
IUUC-Tgu-117079	Taeniopygia guttata	88.32	0.00e+00	1642.00
IUUC-Tru-118062	Takifugu rubripes	71.98	0.00e+00	1382.00
IUUC-Tsy-119507	Tarsius syrichta	79.00	0.00e+00	1459.00
IUUC-Tni-120151	Tetraodon nigroviridis	71.82	0.00e+00	1358.00
IUUC-Tbe-127793	Tupaia belangeri	62.33	0.00e+00	852.00
IUUC-Ttr-129260	Tursiops truncatus	73.89	0.00e+00	1315.00
IUUC-Xtr-132877	Xenopus tropicalis	71.86	0.00e+00	1261.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence