iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022065

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02000076

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000022721.1	ENSCPOT00000025036.1	ENSCPOP00000018658.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.40e-82	277.0	277	599

Active Site

Position(s)	Description	Evidence
569	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k llg
   Q: 277  ENRKRHGSSRSVVDMDLDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLG 361
           556778**************9999778888334444777777777775....89*********************************** PP
   S: 103  kklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegike 188
           +k++++d++ +dp +y+s  + i++++  +++   +++dl+f ++ ++ +   ++eL+p+G nipVt +N +eYv++++e+r+    ++
   Q: 362  RKVNWHDFAFFDPVMYESlRQLILASQssDAEAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQ 450
           ******************5566676664444677789**************************************************** PP
   S: 189  qveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqFvTgssr 273
            ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F+T+s++
   Q: 451  PLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYFWTSSPS 539
           ***********************************************9999999999989999************************** PP
   S: 274  lPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 540  LPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 599
           ***999******..799999.99**********************************9.99875 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MEDVGAEPGS ILTELGGFEV KESKFRREME KLRNQQSRDL SLEVKVDRDR DLLIQQTMRQ 60
LNNHFGRRCA TTPMAVHRVK VTFKDEPGEG SGVARSFYTA IAQAFLSNEK LPNLDCIQNA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGACG TCGGGGCAGA GCCTGGATCA GTATGTATTT TGTGCCCTTT GAATTCTGTT 60
TTACCTGATA AGAACAGATT TCACAGAATA ATTCTGTCAT GCATTTTTTT AAAGATCCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR002004--PABP_HYD

PROSITE

PS50237--HECT
PS51309--PABC

Pfam

PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-010702	Astyanax mexicanus	89.35	0.00e+00	954.00
IUUC-Cel-018165	Caenorhabditis elegans	31.70	9.00e-78	286.00
IUUC-Csv-026131	Ciona savignyi	54.26	3.00e-157	549.00
IUUC-Dme-032192	Drosophila melanogaster	51.97	6.00e-167	583.00
IUUC-Laf-053960	Loxodonta africana	94.10	0.00e+00	990.00
IUUC-Ssc-115470	Sus scrofa	95.67	0.00e+00	993.00
IUUC-Tru-117682	Takifugu rubripes	87.42	0.00e+00	936.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence