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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-106013
UUCD1 version UUC-RaN-00660
Ensembl Protein ID ENSRNOP00000011864.6
UniProt Accession F1M3B3; F1M3B3_RAT
Genbank Protein ID ENSRNOP00000011864
Protein Name Pleckstrin homology domain-interacting protein
Genbank Nucleotide ID AABR07070893
Gene Name Phip
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000008652.6 ENSRNOT00000011864.6 ENSRNOP00000011864.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLMdbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-32 110.9 118 155
UBD/Beta-Prp 5.40e-58 196.9 119 336
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 118  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 155
           8**********955599*****************9987 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s ++cv+f + ++ ++tgs+d  +k+w +++g ll++l gh ae++++  + +  +++ gs D++i+vw l+t+ ++ +l+gh++s+
   Q: 119  HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASI 207
           5567889************************************************99******************************** PP
   S: 98   lslsfsp....sgdklvsGshdrtirvwdletgqclee......tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl..lr 173
           +sl+fsp    s+ +l s+++d ti  w ++ g+   +      t++++ gv ++ ++ + g   l++Gs+D ++r++   +g+   + 
   Q: 208  TSLQFSPlcsgSKRYLSSTGADGTICFWLWDAGTLKINprptkfTERPRPGVQMICSSFSAGgMFLATGSTDHIIRVYFFGSGQPekIS 296
           *********877799************8888888887788************9988877777799*************99666651166 PP
   S: 174  tltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec 214
           +l+  htd+v s++f+ +++++vsgs+dgt ++w++++ e 
   Q: 297  ELEF-HTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREW 336
           7788.*******************************97654 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
VKYYRHLAPD HLLQICHRLG PLLEQEIPQS VPGVQTLLGA GRQSLLRTNK SCKHVVWKGS 60
ALAALHCGRP PESPVNYGSP PNIADTLFSR KLNGKYRLER LVPTAVYQHM KMHKRILGHL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-106013|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGAAGTATT ATAGACACCT TGCACCTGAT CACTTGCTGC AAATCTGTCA TCGACTAGGA 60
CCTCTTCTTG AGCAAGAAAT TCCTCAGAGT GTTCCTGGAG TACAAACTTT ATTAGGAGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-106013|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00439--Bromodomain
PF00400--WD40
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM00320--WD40
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002299 Ailuropoda melanoleuca 93.06 0.00e+00 3067.00
IUUC-Apl-003700 Anas platyrhynchos 84.46 0.00e+00 2815.00
IUUC-Aca-004474 Anolis carolinensis 80.93 0.00e+00 2674.00
IUUC-Bta-013125 Bos taurus 92.95 0.00e+00 3035.00
IUUC-Cja-018868 Callithrix jacchus 91.30 0.00e+00 3105.00
IUUC-Cfa-021179 Canis familiaris 93.41 0.00e+00 3001.00
IUUC-Cpo-022077 Cavia porcellus 89.02 0.00e+00 3001.00
IUUC-Csa-023618 Chlorocebus sabaeus 93.52 0.00e+00 3123.00
IUUC-Cho-024794 Choloepus hoffmanni 84.30 0.00e+00 807.00
IUUC-Dre-028029 Danio rerio 78.98 0.00e+00 1217.00
IUUC-Dno-030048 Dasypus novemcinctus 93.02 0.00e+00 3041.00
IUUC-Dor-030195 Dipodomys ordii 87.52 0.00e+00 1418.00
IUUC-Ete-032748 Echinops telfairi 80.42 0.00e+00 1113.00
IUUC-Eca-034274 Equus caballus 93.86 0.00e+00 3085.00
IUUC-Eeu-034688 Erinaceus europaeus 83.18 0.00e+00 1383.00
IUUC-Fca-035451 Felis catus 92.42 0.00e+00 2964.00
IUUC-Fal-037465 Ficedula albicollis 84.11 0.00e+00 2767.00
IUUC-Gmo-039451 Gadus morhua 68.77 0.00e+00 723.00
IUUC-Gga-040798 Gallus gallus 84.23 0.00e+00 2803.00
IUUC-Ggo-045347 Gorilla gorilla 91.60 0.00e+00 3101.00
IUUC-Hsa-046757 Homo sapiens 93.41 0.00e+00 3096.00
IUUC-Itr-048843 Ictidomys tridecemlineatus 90.50 0.00e+00 1144.00
IUUC-Lch-050646 Latimeria chalumnae 76.82 0.00e+00 2578.00
IUUC-Loc-052672 Lepisosteus oculatus 69.69 0.00e+00 2296.00
IUUC-Laf-054140 Loxodonta africana 93.30 0.00e+00 3132.00
IUUC-Mcc-055061 Macaca mulatta 93.58 0.00e+00 3122.00
IUUC-Mmr-060837 Microcebus murinus 93.64 0.00e+00 3095.00
IUUC-Mdo-061903 Monodelphis domestica 88.89 0.00e+00 2974.00
IUUC-Mmu-063772 Mus musculus 96.76 0.00e+00 3210.00
IUUC-Mpu-066359 Mustela putorius furo 92.97 0.00e+00 2858.00
IUUC-Mlu-067928 Myotis lucifugus 91.88 0.00e+00 3058.00
IUUC-Nle-070094 Nomascus leucogenys 93.52 0.00e+00 3100.00
IUUC-Opr-070971 Ochotona princeps 70.16 0.00e+00 891.00
IUUC-Ont-072221 Oreochromis niloticus 74.08 0.00e+00 1196.00
IUUC-Oan-073185 Ornithorhynchus anatinus 86.14 0.00e+00 2815.00
IUUC-Ocu-074033 Oryctolagus cuniculus 91.71 0.00e+00 2792.00
IUUC-Oga-088578 Otolemur garnettii 93.52 0.00e+00 3086.00
IUUC-Oar-090247 Ovis aries 93.06 0.00e+00 3033.00
IUUC-Ptr-091266 Pan troglodytes 93.12 0.00e+00 3073.00
IUUC-Pan-092734 Papio anubis 93.46 0.00e+00 3118.00
IUUC-Pfo-096191 Poecilia formosa 71.80 0.00e+00 1961.00
IUUC-Pab-098402 Pongo abelii 93.35 0.00e+00 3095.00
IUUC-Pca-101128 Procavia capensis 84.04 0.00e+00 2780.00
IUUC-Pva-103058 Pteropus vampyrus 91.94 0.00e+00 1536.00
IUUC-Sha-107496 Sarcophilus harrisii 89.13 0.00e+00 2990.00
IUUC-Sar-113520 Sorex araneus 88.54 0.00e+00 1493.00
IUUC-Ssc-115461 Sus scrofa 89.72 0.00e+00 2938.00
IUUC-Tgu-116821 Taeniopygia guttata 83.95 0.00e+00 2765.00
IUUC-Tsy-119132 Tarsius syrichta 81.34 0.00e+00 2490.00
IUUC-Tbe-127479 Tupaia belangeri 89.80 0.00e+00 1422.00
IUUC-Ttr-128427 Tursiops truncatus 89.20 0.00e+00 2904.00
IUUC-Vpa-130160 Vicugna pacos 89.66 0.00e+00 2934.00
IUUC-Xtr-132717 Xenopus tropicalis 77.26 0.00e+00 2335.00
Created Date 25-Jun-2017

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