iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007894

Ensembl Protein ID

AAS51209

UniProt Accession

Q75CC8; HRD1_ASHGO

Genbank Protein ID

AAS51209.2

Protein Name

ERAD-associated E3 ubiquitin-protein ligase HRD1; RING-type E3 ubiquitin transferase HRD1

Genbank Nucleotide ID

AE016816

Gene Name

HRD1; ACL019C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_ACL019C	AAS51209	AAS51209

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.60e-11	40.8	320	368

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..........kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++d+          ++  + lpCgH+ h+ Cl+ w        ++++CP+Cr
   Q: 320  CIICMDDMlpttettkmnRR-AKMLPCGHMLHFGCLKSW------MERSQTCPICR 368
           ********9*9988888544.889***************......**********8 PP

Organism

Ashbya gossypii

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).

Protein Sequence
(Fasta)

MPREVSWPMW AMFITATYAL AGWSAYSCAT SFDDPLSALF MASSGVHFVI WGNFLIVHYC 60
LFVWAIIRVL FGQLTAIEYD HIFERLHVVL VTLASIVITM RKTYMAGHMT ILFYTLCLVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTCGGG AAGTTTCCTG GCCCATGTGG GCAATGTTTA TAACAGCGAC GTATGCCTTG 60
GCGGGATGGT CGGCGTATAG CTGTGCAACG AGCTTTGATG ACCCCTTGAG TGCCTTGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0051082--F:unfolded protein binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

ago:AGOS_ACL019C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000344	Aegilops tauschii	37.78	4.00e-15	73.90
IUUC-Aml-001539	Ailuropoda melanoleuca	25.24	6.00e-18	83.60
IUUC-Atr-002892	Amborella trichopoda	27.45	1.00e-15	75.90
IUUC-Apl-003404	Anas platyrhynchos	26.63	7.00e-13	66.60
IUUC-Aca-004799	Anolis carolinensis	24.51	2.00e-18	85.50
IUUC-Aly-006352	Arabidopsis lyrata	21.32	3.00e-16	77.80
IUUC-Ath-006773	Arabidopsis thaliana	21.56	1.00e-16	78.60
IUUC-Acl-008041	Aspergillus clavatus	25.26	8.00e-25	106.00
IUUC-Afl-008427	Aspergillus flavus	23.96	6.00e-23	100.00
IUUC-Afu-009023	Aspergillus fumigatus	23.37	2.00e-23	102.00
IUUC-Ani-009133	Aspergillus nidulans	23.56	1.00e-25	109.00
IUUC-Ang-009612	Aspergillus niger	25.07	3.00e-22	98.20
IUUC-Aor-010045	Aspergillus oryzae	22.72	5.00e-24	103.00
IUUC-Ate-010533	Aspergillus terreus	22.76	4.00e-23	100.00
IUUC-Ame-011083	Astyanax mexicanus	25.24	7.00e-18	83.20
IUUC-Bgr-012122	Blumeria graminis	36.36	1.00e-14	72.80
IUUC-Bta-013375	Bos taurus	25.24	1.00e-17	82.80
IUUC-Bci-013675	Botrytis cinerea	21.82	5.00e-16	77.80
IUUC-Bdi-015070	Brachypodium distachyon	37.78	1.00e-15	75.50
IUUC-Bol-015674	Brassica oleracea	22.69	3.00e-16	77.40
IUUC-Bra-017516	Brassica rapa	23.71	2.00e-16	77.80
IUUC-Cel-018422	Caenorhabditis elegans	25.91	3.00e-16	77.80
IUUC-Cja-019779	Callithrix jacchus	23.89	7.00e-14	70.10
IUUC-Cfa-020189	Canis familiaris	25.16	9.00e-19	86.70
IUUC-Cpo-022209	Cavia porcellus	25.24	1.00e-18	85.50
IUUC-Cre-022743	Chlamydomonas reinhardtii	25.00	8.00e-18	82.00
IUUC-Csa-023571	Chlorocebus sabaeus	25.24	5.00e-18	84.00
IUUC-Cho-024889	Choloepus hoffmanni	40.79	1.00e-13	68.90
IUUC-Cin-025215	Ciona intestinalis	23.50	1.00e-13	69.30
IUUC-Csv-026160	Ciona savignyi	31.51	8.00e-15	72.80
IUUC-Cgl-026578	Colletotrichum gloeosporioides	31.34	2.00e-06	45.10
IUUC-Cne-027002	Cryptococcus neoformans	23.08	8.00e-24	103.00
IUUC-Cme-027285	Cyanidioschyzon merolae	21.48	2.00e-13	68.60
IUUC-Dre-027999	Danio rerio	26.47	4.00e-19	87.40
IUUC-Dno-029250	Dasypus novemcinctus	25.24	7.00e-18	83.60
IUUC-Dor-030718	Dipodomys ordii	25.24	9.00e-18	82.80
IUUC-Dse-031498	Dothistroma septosporum	23.84	6.00e-09	54.30
IUUC-Dme-031969	Drosophila melanogaster	27.07	9.00e-24	102.00
IUUC-Ete-032962	Echinops telfairi	30.69	1.00e-11	62.40
IUUC-Eca-033258	Equus caballus	25.24	5.00e-18	83.60
IUUC-Eeu-035349	Erinaceus europaeus	31.18	2.00e-10	58.90
IUUC-Fca-035980	Felis catus	25.48	6.00e-19	86.70
IUUC-Fal-036758	Ficedula albicollis	26.47	5.00e-13	67.00
IUUC-Fox-037902	Fusarium oxysporum	23.41	2.00e-23	102.00
IUUC-Fso-038418	Fusarium solani	23.36	4.00e-17	81.30
IUUC-Gmo-039288	Gadus morhua	24.33	8.00e-14	69.70
IUUC-Ggr-040076	Gaeumannomyces graminis	25.19	4.00e-23	101.00
IUUC-Gga-041214	Gallus gallus	45.16	5.00e-13	65.50
IUUC-Gac-042347	Gasterosteus aculeatus	24.68	2.00e-18	85.10
IUUC-Gma-044123	Glycine max	28.12	5.00e-15	73.90
IUUC-Ggo-044858	Gorilla gorilla	25.16	7.00e-18	83.20
IUUC-Hsa-046412	Homo sapiens	25.24	7.00e-18	83.20
IUUC-Hvu-047279	Hordeum vulgare	37.78	2.00e-15	74.30
IUUC-Itr-048924	Ictidomys tridecemlineatus	25.24	8.00e-18	83.20
IUUC-Kpa-049117	Komagataella pastoris	23.15	6.00e-25	106.00
IUUC-Lch-049533	Latimeria chalumnae	35.92	6.00e-14	70.50
IUUC-Lpe-050959	Leersia perrieri	40.74	2.00e-10	56.20
IUUC-Loc-052843	Lepisosteus oculatus	42.11	2.00e-14	70.50
IUUC-Lma-052997	Leptosphaeria maculans	22.16	1.00e-20	92.40
IUUC-Laf-053482	Loxodonta africana	25.16	1.00e-17	82.40
IUUC-Mcc-055075	Macaca mulatta	25.24	6.00e-18	83.60
IUUC-Meu-056683	Macropus eugenii	30.50	1.00e-13	68.90
IUUC-Mor-057082	Magnaporthe oryzae	25.81	7.00e-25	107.00
IUUC-Mpo-057573	Magnaporthe poae	25.14	1.00e-20	92.40
IUUC-Mtr-058601	Medicago truncatula	21.43	3.00e-15	74.30
IUUC-Mla-059168	Melampsora laricipopulina	22.50	2.00e-19	89.00
IUUC-Mga-059510	Meleagris gallopavo	37.08	2.00e-13	67.00
IUUC-Mvi-060515	Microbotryum violaceum	26.05	1.00e-16	79.70
IUUC-Mmr-060922	Microcebus murinus	24.60	3.00e-18	84.70
IUUC-Mdo-062491	Monodelphis domestica	40.79	9.00e-14	69.70
IUUC-Mmu-063770	Mus musculus	25.24	5.00e-18	84.00
IUUC-Mac-064789	Musa acuminata	23.16	1.00e-18	85.90
IUUC-Mpu-066107	Mustela putorius furo	25.24	1.00e-17	82.80
IUUC-Mlu-067918	Myotis lucifugus	24.92	1.00e-16	79.30
IUUC-Nfi-068389	Neosartorya fischeri	23.59	2.00e-23	102.00
IUUC-Ncr-068742	Neurospora crassa	25.07	6.00e-21	94.00
IUUC-Nle-069139	Nomascus leucogenys	25.24	7.00e-18	83.20
IUUC-Opr-070898	Ochotona princeps	40.26	9.00e-14	69.70
IUUC-Ont-071991	Oreochromis niloticus	25.08	2.00e-18	84.70
IUUC-Oan-073717	Ornithorhynchus anatinus	26.34	2.00e-13	68.60
IUUC-Ocu-074065	Oryctolagus cuniculus	25.88	1.00e-18	86.30
IUUC-Oba-075221	Oryza barthii	33.90	2.00e-15	74.70
IUUC-Obr-076914	Oryza brachyantha	37.93	6.00e-15	73.20
IUUC-Ogl-077453	Oryza glaberrima	43.14	5.00e-10	55.50
IUUC-Ogu-078124	Oryza glumaepatula	33.90	2.00e-15	74.70
IUUC-Oin-080013	Oryza indica	33.90	2.00e-15	74.70
IUUC-Olo-080247	Oryza longistaminata	33.90	3.00e-15	74.30
IUUC-Ome-081769	Oryza meridionalis	35.09	3.00e-15	74.30
IUUC-Oni-082946	Oryza nivara	33.90	2.00e-15	74.70
IUUC-Opu-083264	Oryza punctata	35.06	3.00e-09	56.20
IUUC-Oru-085114	Oryza rufipogon	33.90	2.00e-15	74.70
IUUC-Osa-085829	Oryza sativa	37.93	5.00e-15	73.60
IUUC-Ola-087449	Oryzias latipes	26.28	1.00e-17	82.80
IUUC-Olu-087894	Ostreococcus lucimarinus	25.59	1.00e-19	87.80
IUUC-Oga-089036	Otolemur garnettii	25.24	5.00e-18	84.00
IUUC-Oar-089715	Ovis aries	25.24	9.00e-18	83.20
IUUC-Ptr-091000	Pan troglodytes	25.24	8.00e-18	83.20
IUUC-Pan-092187	Papio anubis	25.16	4.00e-18	84.00
IUUC-Psi-093377	Pelodiscus sinensis	40.79	1.00e-13	69.30
IUUC-Pma-094759	Petromyzon marinus	30.77	2.00e-15	74.70
IUUC-Pno-094883	Phaeosphaeria nodorum	23.10	7.00e-18	83.60
IUUC-Ppa-095684	Physcomitrella patens	30.99	1.00e-15	75.90
IUUC-Pfo-096861	Poecilia formosa	25.32	1.00e-16	79.00
IUUC-Pab-098030	Pongo abelii	25.24	7.00e-18	83.60
IUUC-Pop-098833	Populus trichocarpa	33.87	1.00e-16	77.40
IUUC-Pca-100191	Procavia capensis	25.88	5.00e-18	84.00
IUUC-Ppe-101829	Prunus persica	41.33	8.00e-14	69.70
IUUC-Pva-102689	Pteropus vampyrus	25.24	1.00e-17	82.40
IUUC-Pgr-103286	Puccinia graminis	23.40	1.00e-17	82.80
IUUC-Ptt-103919	Puccinia triticina	21.93	5.00e-17	80.10
IUUC-Pte-104372	Pyrenophora teres	23.16	1.00e-21	95.90
IUUC-Pyt-104456	Pyrenophora triticirepentis	23.02	2.00e-21	95.50
IUUC-Rno-105723	Rattus norvegicus	25.24	6.00e-18	83.60
IUUC-Sce-106348	Saccharomyces cerevisiae	31.86	1.00e-50	191.00
IUUC-Sha-107300	Sarcophilus harrisii	30.50	7.00e-14	69.70
IUUC-Sja-107685	Schizosaccharomyces japonicus	25.20	1.00e-22	99.00
IUUC-Spo-108308	Schizosaccharomyces pombe	25.42	3.00e-21	94.70
IUUC-Ssl-108558	Sclerotinia sclerotiorum	34.75	6.00e-14	70.90
IUUC-Smo-109223	Selaginella moellendorffii	24.32	3.00e-17	80.50
IUUC-Sit-110276	Setaria italica	39.76	4.00e-15	73.90
IUUC-Sly-111531	Solanum lycopersicum	21.43	3.00e-14	71.20
IUUC-Stu-112048	Solanum tuberosum	37.65	4.00e-14	70.50
IUUC-Sar-113397	Sorex araneus	27.81	1.00e-12	65.50
IUUC-Sbi-114192	Sorghum bicolor	38.89	4.00e-16	77.40
IUUC-Sre-115212	Sporisorium reilianum	24.76	8.00e-14	70.10
IUUC-Ssc-116323	Sus scrofa	25.24	1.00e-17	82.80
IUUC-Tgu-116717	Taeniopygia guttata	26.47	8.00e-13	66.60
IUUC-Tru-118045	Takifugu rubripes	25.80	4.00e-18	84.00
IUUC-Tsy-119442	Tarsius syrichta	27.27	3.00e-12	64.30
IUUC-Tni-120106	Tetraodon nigroviridis	31.21	3.00e-14	71.20
IUUC-Tca-121462	Theobroma cacao	39.13	4.00e-14	70.90
IUUC-Tre-122204	Trichoderma reesei	42.35	3.00e-15	74.70
IUUC-Tvi-122550	Trichoderma virens	47.22	7.00e-15	73.90
IUUC-Tae-124064	Triticum aestivum	36.46	7.00e-16	76.30
IUUC-Tur-126538	Triticum urartu	37.78	2.00e-14	72.00
IUUC-Tme-127197	Tuber melanosporum	24.92	3.00e-15	75.50
IUUC-Tbe-127385	Tupaia belangeri	40.26	1.00e-13	68.90
IUUC-Ttr-128795	Tursiops truncatus	25.24	8.00e-18	83.20
IUUC-Uma-129401	Ustilago maydis	34.65	2.00e-11	62.40
IUUC-Vda-129968	Verticillium dahliae	25.72	1.00e-20	92.80
IUUC-Vpa-130483	Vicugna pacos	34.12	5.00e-12	63.50
IUUC-Vvi-130944	Vitis vinifera	22.22	7.00e-16	76.30
IUUC-Xtr-131884	Xenopus tropicalis	26.35	2.00e-15	75.10
IUUC-Xma-133488	Xiphophorus maculatus	25.32	2.00e-16	78.60
IUUC-Yli-134552	Yarrowia lipolytica	25.40	2.00e-16	78.20
IUUC-Zma-135183	Zea mays	41.05	2.00e-16	78.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence