iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-058088

Ensembl Protein ID

KEH31409

UniProt Accession

A0A072UNN4; A0A072UNN4_MEDTR

Genbank Protein ID

KEH31409.1

Protein Name

E3 ubiquitin-protein ligase UPL1-like protein

Genbank Nucleotide ID

CM001220

Gene Name

MTR_4g094708

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_4g094708	KEH31409	KEH31409

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.50e-120	402.2	3419	3757
UBD/Alpha-Helix/UBA	1.00e-08	36.5	1296	1335
UBD/Alpha-Helix/UBM	4.30e-14	53.1	2700	2725

Active Site

Position(s)	Description	Evidence
3725	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklll 101
           +dlk+rl+v+f+gEeg+d+gG+tre+++lls+ ++++ + lf ++ ++++t+qpnp+s ++ +ehl++F+f+Gr++gkal+dg+lld+ +++sfyk++l
   Q: 3419 QDLKSRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLF-TTVGNNATFQPNPNSVYQ-TEHLSYFKFVGRVVGKALFDGQLLDVYFTRSFYKHIL 3515
           79************************************9999.566688999******986.5************************************ PP
   S: 102  gkklsledleevdpelykslkeikenaesdieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafre 195
           g+k++++d+e+vdp++yk+lk+++en+ sdi +l++ +   ++ee+      +e++++eLkpgG+ni+Vt+e k+eYv+lv+e+ l++ i+ q+++f e
   Q: 3516 GVKVTYHDIEAVDPDYYKNLKWMLENDVSDIPDLTFSMD--ADEEKlilyeKNEVTDYELKPGGRNIRVTEETKHEYVDLVAEHLLTNAIRPQINSFLE 3612
           **************************6666666533333..444446786677888999**************************************** PP
   S: 196  GfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvir 290
           Gfne++p el+s+F+ +elelli+G +eid++dlk++t+y+g yt  s+++qwFwev+++f++e+ +++LqFvTg+s++Pl+Gf++l+    p++f+i+
   Q: 3613 GFNEMVPRELISIFNDKELELLISGLPEIDLDDLKANTEYTG-YTVASNVVQWFWEVVKSFNKEDMARLLQFVTGTSKVPLEGFKALQgisgPQKFQIH 3710
           ****************************************66.******************************************************** PP
   S: 291  k.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           k ++++drlPs++TCfn+L+LPeY+ske+l+++Ll+Ai+e+ +gF++
   Q: 3711 KaYGAPDRLPSAHTCFNQLDLPEYTSKEQLQDRLLLAIHEAsEGFGF 3757
           *99999***********************************9***85 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           de  ++ +veMGF+r +a +aLr+   n++e+A+e+L+++
   Q: 1296 DEATIATIVEMGFSRARAEEALRRVeTNSVEMAMEWLFSH 1335
           7889********************66************97 PP

UBD/Alpha-Helix/UBM

   S: 3    sqvDpeVfsqLPeeiQeEvmaelrqq 28
           +++Dpe++++LP+eiQ+Ev+a +r q
   Q: 2700 EDIDPEFLAALPPEIQAEVLAQQRAQ 2725
           79*******************99976 PP

Organism

Medicago truncatula

Protein Sequence
(Fasta)

MKLKRKRALE VPQKIRCFIN RVAAVPLENI QEPLKDFTWE FDKGDFHHWV DLFNHFDSFF 60
EKYIKPRKDL QIDDNFLDSD PPFPREAVLQ ILRVIRIILD NCANKHFYGS YEQHLSSLLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTTCTCCC TGTACTTGTT TTTCTCTTCT CTTCTCTTCT TCAGTTGGGT TTTTCTTCAT 60
TCTTCTCTCT CTCTCTCTCT CTCTCACTAC TTTTACTTCA TCGATAAACC AATCTTCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR003903--UIM_dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50330--UIM

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mtr:MTR_4g094708

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001684	Ailuropoda melanoleuca	52.69	2.00e-126	448.00
IUUC-Ath-007472	Arabidopsis thaliana	61.68	0.00e+00	4098.00
IUUC-Bra-016637	Brassica rapa	58.89	0.00e+00	3805.00
IUUC-Cho-024718	Choloepus hoffmanni	54.19	5.00e-117	416.00
IUUC-Dno-029680	Dasypus novemcinctus	52.69	2.00e-126	448.00
IUUC-Eca-033915	Equus caballus	52.11	2.00e-124	442.00
IUUC-Fca-035824	Felis catus	52.69	3.00e-126	447.00
IUUC-Gga-040309	Gallus gallus	57.01	5.00e-98	350.00
IUUC-Gma-044247	Glycine max	83.66	0.00e+00	5716.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	52.69	2.00e-126	447.00
IUUC-Lch-050252	Latimeria chalumnae	53.04	4.00e-126	447.00
IUUC-Lpe-050915	Leersia perrieri	55.34	0.00e+00	3473.00
IUUC-Loc-052472	Lepisosteus oculatus	52.93	1.00e-126	449.00
IUUC-Mcc-055085	Macaca mulatta	52.69	3.00e-126	447.00
IUUC-Meu-056436	Macropus eugenii	41.06	5.00e-78	285.00
IUUC-Mmr-060820	Microcebus murinus	52.69	2.00e-126	448.00
IUUC-Mdo-062930	Monodelphis domestica	52.69	2.00e-126	448.00
IUUC-Mac-065557	Musa acuminata	52.92	0.00e+00	1596.00
IUUC-Opr-070443	Ochotona princeps	44.64	9.00e-95	341.00
IUUC-Ocu-074178	Oryctolagus cuniculus	52.69	2.00e-126	449.00
IUUC-Oba-075252	Oryza barthii	56.33	0.00e+00	3488.00
IUUC-Obr-076762	Oryza brachyantha	55.89	0.00e+00	3466.00
IUUC-Ogl-077590	Oryza glaberrima	58.70	0.00e+00	1265.00
IUUC-Ogu-077981	Oryza glumaepatula	54.51	0.00e+00	2172.00
IUUC-Oin-079663	Oryza indica	54.64	0.00e+00	3214.00
IUUC-Olo-080326	Oryza longistaminata	56.34	0.00e+00	3474.00
IUUC-Oni-082342	Oryza nivara	56.36	0.00e+00	3516.00
IUUC-Opu-083428	Oryza punctata	56.33	0.00e+00	3481.00
IUUC-Oru-084559	Oryza rufipogon	56.33	0.00e+00	3494.00
IUUC-Osa-086200	Oryza sativa	58.74	0.00e+00	1298.00
IUUC-Oar-090210	Ovis aries	52.69	4.00e-126	447.00
IUUC-Ppa-095657	Physcomitrella patens	48.51	0.00e+00	1717.00
IUUC-Pop-099520	Populus trichocarpa	68.95	0.00e+00	4584.00
IUUC-Pca-100596	Procavia capensis	44.32	1.00e-87	317.00
IUUC-Ppe-102109	Prunus persica	72.69	0.00e+00	4912.00
IUUC-Sce-106449	Saccharomyces cerevisiae	31.85	7.00e-129	456.00
IUUC-Sha-106961	Sarcophilus harrisii	52.69	2.00e-126	448.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	45.99	2.00e-98	353.00
IUUC-Sit-110149	Setaria italica	55.44	0.00e+00	3328.00
IUUC-Sly-111285	Solanum lycopersicum	64.47	0.00e+00	4424.00
IUUC-Stu-112501	Solanum tuberosum	74.54	7.00e-151	525.00
IUUC-Tni-120836	Tetraodon nigroviridis	52.46	5.00e-124	440.00
IUUC-Tca-121646	Theobroma cacao	71.18	0.00e+00	4768.00
IUUC-Tbe-127408	Tupaia belangeri	42.93	4.00e-86	312.00
IUUC-Ttr-129253	Tursiops truncatus	52.69	4.00e-126	447.00
IUUC-Vpa-130708	Vicugna pacos	52.69	6.00e-126	447.00
IUUC-Vvi-131559	Vitis vinifera	73.80	0.00e+00	1981.00
IUUC-Xtr-132123	Xenopus tropicalis	50.81	9.00e-114	406.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence