iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028383

Ensembl Protein ID

ENSDARP00000064994.5

UniProt Accession

Q7SZR5; SUMO1_DANRE

Genbank Protein ID

AAH56283.1; AAH67553.1

Protein Name

Small ubiquitin-related modifier 1

Genbank Nucleotide ID

BC056283; BC067553

Gene Name

sumo1; zgc:65934; zgc:85634

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000044267.5	ENSDART00000064995.5	ENSDARP00000064994.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/SUMO	3.40e-27	95.9	19	96
ULD/UDP/UBQ/UBQ_Other	3.10e-08	34.3	23	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 7    apvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           ++++lkv gqd se++fk+k++++lkkl+e+ Y +r+++ +ns+rf+f+gq+i ++ tp+el++eded+ie++++++GG
   Q: 19   EYIKLKVIGQDNSEIHFKVKMTTHLKKLKES-YSQRQGVPVNSLRFLFEGQRITDNLTPKELGMEDEDVIEVYQEQTGG 96
           79*****************************.**********************************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
           ++v   d+se  +kv+ ++  ++LKe  ++++g+p+++ r +++G+ + d+ t +++g+ d+++i +++++ 
   Q: 23   LKVIGQDNSEIHFKVKMTTHLKKLKESYSQRQGVPVNSLRFLFEGQRITDNLTPKELGMEDEDVIEVYQEQT 94
           5666677788889999999*************************************************9875 PP

Organism

Danio rerio

Functional Description
(View)

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

Protein Sequence
(Fasta)

MSDTETKPSS DGGEKKDGEY IKLKVIGQDN SEIHFKVKMT THLKKLKESY SQRQGVPVNS 60
LRFLFEGQRI TDNLTPKELG MEDEDVIEVY QEQTGGCRND

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Nucleotide Sequence
(Fasta)

CAATGACGTC AACGGCGCTG TGTTGTGGGT CTGCTGGTAG CACTAGCAAA ACCTCTCATT 60
ACTGTACATA ACACTGTATC GTTTAAATCA AACAATCTTG ATCTACAGAA GGGCTGCACA 120

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Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0097165--C:nuclear stress granule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031386--F:protein tag
GO:0071276--P:cellular response to cadmium ion
GO:0034605--P:cellular response to heat
GO:0043009--P:chordate embryonic development
GO:0060216--P:definitive hemopoiesis
GO:0016925--P:protein sumoylation

KEGG

dre:406438

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001606	Ailuropoda melanoleuca	87.10	3.00e-42	162.00
IUUC-Apl-003638	Anas platyrhynchos	88.17	8.00e-43	164.00
IUUC-Aca-004710	Anolis carolinensis	88.66	4.00e-45	172.00
IUUC-Ago-007749	Ashbya gossypii	47.96	2.00e-17	80.10
IUUC-Ame-011662	Astyanax mexicanus	94.00	2.00e-49	186.00
IUUC-Bta-013491	Bos taurus	86.60	5.00e-44	168.00
IUUC-Cel-018251	Caenorhabditis elegans	66.25	2.00e-28	116.00
IUUC-Cja-019109	Callithrix jacchus	87.10	2.00e-42	163.00
IUUC-Cfa-020657	Canis familiaris	86.60	5.00e-44	168.00
IUUC-Cpo-022508	Cavia porcellus	87.10	2.00e-42	162.00
IUUC-Cre-022970	Chlamydomonas reinhardtii	45.36	8.00e-19	84.70
IUUC-Csa-023026	Chlorocebus sabaeus	85.57	5.00e-34	135.00
IUUC-Cho-024767	Choloepus hoffmanni	91.18	2.00e-32	131.00
IUUC-Cne-027072	Cryptococcus neoformans	52.31	2.00e-14	70.90
IUUC-Dno-029820	Dasypus novemcinctus	86.60	5.00e-44	168.00
IUUC-Ete-032782	Echinops telfairi	64.52	7.00e-26	108.00
IUUC-Eca-033958	Equus caballus	86.60	5.00e-44	168.00
IUUC-Eeu-034822	Erinaceus europaeus	86.60	4.00e-44	169.00
IUUC-Fca-035601	Felis catus	87.10	3.00e-42	162.00
IUUC-Fal-036740	Ficedula albicollis	88.17	1.00e-42	164.00
IUUC-Gmo-038847	Gadus morhua	91.67	9.00e-35	137.00
IUUC-Gga-040129	Gallus gallus	87.63	1.00e-44	170.00
IUUC-Gac-042112	Gasterosteus aculeatus	90.10	1.00e-48	184.00
IUUC-Ggo-045413	Gorilla gorilla	86.60	5.00e-44	168.00
IUUC-Hsa-046108	Homo sapiens	86.60	5.00e-44	168.00
IUUC-Itr-047968	Ictidomys tridecemlineatus	84.16	3.00e-44	169.00
IUUC-Lch-049881	Latimeria chalumnae	82.47	8.00e-38	147.00
IUUC-Loc-052189	Lepisosteus oculatus	89.69	9.00e-46	174.00
IUUC-Laf-053478	Loxodonta africana	87.10	2.00e-42	162.00
IUUC-Mcc-055059	Macaca mulatta	72.16	1.00e-35	142.00
IUUC-Meu-056112	Macropus eugenii	87.63	1.00e-44	171.00
IUUC-Mla-059030	Melampsora laricipopulina	39.08	2.00e-08	51.60
IUUC-Mga-060035	Meleagris gallopavo	88.17	7.00e-43	164.00
IUUC-Mmr-060903	Microcebus murinus	86.60	5.00e-44	168.00
IUUC-Mdo-062633	Monodelphis domestica	87.63	9.00e-45	171.00
IUUC-Mmu-063272	Mus musculus	86.60	5.00e-44	168.00
IUUC-Mpu-066505	Mustela putorius furo	87.10	3.00e-42	163.00
IUUC-Mlu-067991	Myotis lucifugus	85.57	3.00e-39	152.00
IUUC-Nle-069344	Nomascus leucogenys	91.30	2.00e-33	132.00
IUUC-Opr-070351	Ochotona princeps	40.21	5.00e-10	56.60
IUUC-Ont-071436	Oreochromis niloticus	90.10	1.00e-48	184.00
IUUC-Ocu-074220	Oryctolagus cuniculus	86.46	3.00e-43	166.00
IUUC-Ola-086373	Oryzias latipes	88.00	2.00e-46	176.00
IUUC-Olu-087670	Ostreococcus lucimarinus	45.71	4.00e-16	75.90
IUUC-Oga-088024	Otolemur garnettii	80.21	3.00e-40	156.00
IUUC-Oar-089991	Ovis aries	84.54	3.00e-42	162.00
IUUC-Ptr-090688	Pan troglodytes	84.54	8.00e-43	164.00
IUUC-Pan-092204	Papio anubis	86.60	5.00e-44	168.00
IUUC-Psi-093396	Pelodiscus sinensis	88.17	8.00e-43	164.00
IUUC-Pfo-096306	Poecilia formosa	88.12	4.00e-47	179.00
IUUC-Pab-098393	Pongo abelii	86.60	6.00e-44	170.00
IUUC-Pca-100237	Procavia capensis	85.57	5.00e-42	162.00
IUUC-Pva-102353	Pteropus vampyrus	84.81	6.00e-34	135.00
IUUC-Pgr-103683	Puccinia graminis	39.77	4.00e-15	73.20
IUUC-Rno-105286	Rattus norvegicus	86.60	5.00e-44	168.00
IUUC-Sce-106231	Saccharomyces cerevisiae	46.53	1.00e-17	80.90
IUUC-Sha-106712	Sarcophilus harrisii	91.18	8.00e-33	131.00
IUUC-Spo-108261	Schizosaccharomyces pombe	55.42	3.00e-21	93.60
IUUC-Sit-110664	Setaria italica	30.85	2.00e-07	48.10
IUUC-Sar-113550	Sorex araneus	87.10	2.00e-42	162.00
IUUC-Sre-115172	Sporisorium reilianum	51.02	1.00e-21	94.00
IUUC-Ssc-115837	Sus scrofa	83.51	9.00e-43	164.00
IUUC-Tgu-117064	Taeniopygia guttata	88.17	7.00e-43	164.00
IUUC-Tru-117752	Takifugu rubripes	88.12	7.00e-47	177.00
IUUC-Tsy-119358	Tarsius syrichta	85.33	6.00e-32	129.00
IUUC-Tni-120621	Tetraodon nigroviridis	90.10	1.00e-48	183.00
IUUC-Tae-124484	Triticum aestivum	47.92	4.00e-21	92.40
IUUC-Tbe-127355	Tupaia belangeri	64.52	7.00e-26	108.00
IUUC-Ttr-128166	Tursiops truncatus	86.60	7.00e-44	169.00
IUUC-Uma-129444	Ustilago maydis	50.00	3.00e-21	92.80
IUUC-Vpa-130172	Vicugna pacos	86.60	5.00e-44	169.00
IUUC-Xtr-132473	Xenopus tropicalis	82.65	5.00e-42	161.00
IUUC-Xma-133814	Xiphophorus maculatus	89.11	6.00e-48	181.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence