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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063546
UUCD1 version UUC-MuM-00986
Ensembl Protein ID ENSMUSP00000027173.8
UniProt Accession Q9JJA4; Q9CST3; Q9JKF5; WDR12_MOUSE
Genbank Protein ID AAL29680.1; AAL29681.1; AAF44683.1; BAA95091.1; BAB25072.1; BAB27979.3; BAB30336.1; BAC27402.1; AAH04748.1; AAH52386.1
Protein Name Ribosome biogenesis protein WDR12; WD repeat-containing protein 12
Genbank Nucleotide ID AY059431; AY059432; AF239765; AB041608; AK007500; AK012022; AK016611; AK031436; BC004748; BC052386
Gene Name Wdr12; MNCb-5414
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026019.15 ENSMUST00000027173.14 ENSMUSP00000027173.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.20e-42 140.7 255 290
UBD/Beta-Prp 8.00e-46 157.7 246 412
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gHt+ ++++ +sd   ++s+s+D+ti+vWD+ +g l
   Q: 255  GHTEAISSVLWSDaEEICSASWDHTIRVWDVESGGL 290
           8**********999*****************99976 PP
   

   UBD/Beta-Prp
   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t+++++tl+gh++ + s+ +s   + + s+s+d tirvwd+e+g   + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd   k g
   Q: 246  TRTPLVTLSGHTEAISSVLWSD-AEEICSASWDHTIRVWDVESGGLKS-TLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPrtKDG 331
           67899****************9.99**********************9.***987.99**************************54456 PP
   S: 170  kllrtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +l+    t+ ht+ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v+sv+ + ++ +l+sg++D+ ++ +
   Q: 332  SLVSLSlTS-HTGWVTSVKWSPTHeQQLISGSLDNIVKLWDTRsCKAPLYDLAAHEDKVLSVDWT-DTGLLLSGGADNKLYSY 412
           666644366.************9889*****************54566****************9.999*********99887 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Protein Sequence
(Fasta)
MAQLQARFYS ENKKYAVDDV PFSIPAAAEV ADLSNIINKL LETKNELHKH VEFDFLIKGQ 60
FLRVPLVKHM ELENISSEEV VELEYVEKYT APQPEQCMFH DDWISSIEGA EEWILSGSYD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063546|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCAGCCTGC CTTCTCCCGG CCGCGGGGCC CCTCCCGGGC CCACGGCGAA GGAGCCGCCG 60
TGGAGGCGGA CGAGGGCGCA GGGACAGCGC ACAGCGGCGT CCGGCGACGG CCGGGGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063546|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08154--NLE
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0008283--P:cell proliferation
GO:0000460--P:maturation of 5.8S rRNA
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470--P:maturation of LSU-rRNA
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway
KEGG mmu:57750
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000532 Aegilops tauschii 31.90 5.00e-57 214.00
IUUC-Aml-001997 Ailuropoda melanoleuca 94.15 0.00e+00 756.00
IUUC-Atr-002544 Amborella trichopoda 32.86 4.00e-57 215.00
IUUC-Apl-003981 Anas platyrhynchos 86.70 0.00e+00 666.00
IUUC-Aca-004370 Anolis carolinensis 83.06 0.00e+00 718.00
IUUC-Aly-006455 Arabidopsis lyrata 33.41 2.00e-58 219.00
IUUC-Ath-006669 Arabidopsis thaliana 33.66 3.00e-54 206.00
IUUC-Ago-007864 Ashbya gossypii 29.55 8.00e-39 154.00
IUUC-Acl-008177 Aspergillus clavatus 29.20 2.00e-38 153.00
IUUC-Afl-008617 Aspergillus flavus 29.02 7.00e-38 151.00
IUUC-Afu-008752 Aspergillus fumigatus 28.54 9.00e-35 141.00
IUUC-Ani-009136 Aspergillus nidulans 30.26 1.00e-37 151.00
IUUC-Ang-009701 Aspergillus niger 28.46 7.00e-36 145.00
IUUC-Aor-009884 Aspergillus oryzae 29.02 1.00e-37 150.00
IUUC-Ate-010472 Aspergillus terreus 30.68 6.00e-23 101.00
IUUC-Ame-011432 Astyanax mexicanus 76.60 0.00e+00 669.00
IUUC-Bgr-012218 Blumeria graminis 27.65 8.00e-33 134.00
IUUC-Bta-012829 Bos taurus 93.38 0.00e+00 778.00
IUUC-Bci-013953 Botrytis cinerea 29.12 4.00e-35 142.00
IUUC-Bdi-014351 Brachypodium distachyon 34.60 2.00e-55 209.00
IUUC-Bol-015618 Brassica oleracea 34.03 9.00e-55 207.00
IUUC-Bra-017876 Brassica rapa 33.74 1.00e-56 214.00
IUUC-Cel-018569 Caenorhabditis elegans 32.52 1.00e-49 190.00
IUUC-Cja-019468 Callithrix jacchus 93.14 0.00e+00 760.00
IUUC-Cfa-020471 Canis familiaris 92.67 0.00e+00 746.00
IUUC-Cpo-022260 Cavia porcellus 92.91 0.00e+00 761.00
IUUC-Cre-022614 Chlamydomonas reinhardtii 32.98 5.00e-42 165.00
IUUC-Csa-023989 Chlorocebus sabaeus 93.62 0.00e+00 765.00
IUUC-Cho-024426 Choloepus hoffmanni 90.16 3.00e-162 564.00
IUUC-Cin-025789 Ciona intestinalis 42.86 5.00e-99 354.00
IUUC-Cne-027063 Cryptococcus neoformans 24.16 2.00e-21 97.10
IUUC-Dre-027907 Danio rerio 77.07 0.00e+00 677.00
IUUC-Dno-029225 Dasypus novemcinctus 91.96 0.00e+00 768.00
IUUC-Dor-031082 Dipodomys ordii 77.07 2.00e-171 595.00
IUUC-Dse-031308 Dothistroma septosporum 27.53 8.00e-37 147.00
IUUC-Dme-032189 Drosophila melanogaster 40.88 7.00e-94 337.00
IUUC-Ete-032247 Echinops telfairi 85.58 0.00e+00 711.00
IUUC-Eca-034285 Equus caballus 93.85 0.00e+00 778.00
IUUC-Eeu-035322 Erinaceus europaeus 84.67 0.00e+00 659.00
IUUC-Fca-036114 Felis catus 93.62 0.00e+00 779.00
IUUC-Fal-036891 Ficedula albicollis 86.16 5.00e-179 620.00
IUUC-Fox-037965 Fusarium oxysporum 25.81 2.00e-35 143.00
IUUC-Fso-038244 Fusarium solani 26.44 1.00e-35 144.00
IUUC-Gmo-039040 Gadus morhua 75.89 0.00e+00 680.00
IUUC-Ggr-040093 Gaeumannomyces graminis 24.55 6.00e-12 65.50
IUUC-Gga-040610 Gallus gallus 83.92 0.00e+00 732.00
IUUC-Gac-042117 Gasterosteus aculeatus 75.18 0.00e+00 653.00
IUUC-Gma-043146 Glycine max 35.85 6.00e-67 248.00
IUUC-Ggo-045179 Gorilla gorilla 93.14 0.00e+00 756.00
IUUC-Hsa-046114 Homo sapiens 93.85 0.00e+00 761.00
IUUC-Hvu-047331 Hordeum vulgare 32.90 8.00e-53 201.00
IUUC-Itr-048275 Ictidomys tridecemlineatus 94.33 0.00e+00 783.00
IUUC-Kpa-049304 Komagataella pastoris 29.15 2.00e-42 166.00
IUUC-Lch-050655 Latimeria chalumnae 76.42 7.00e-149 519.00
IUUC-Lpe-051675 Leersia perrieri 33.97 5.00e-59 222.00
IUUC-Loc-052868 Lepisosteus oculatus 79.91 0.00e+00 680.00
IUUC-Lma-053258 Leptosphaeria maculans 26.60 1.00e-32 135.00
IUUC-Laf-053993 Loxodonta africana 91.73 0.00e+00 771.00
IUUC-Mcc-055128 Macaca mulatta 76.60 3.00e-174 604.00
IUUC-Meu-056501 Macropus eugenii 76.94 4.00e-165 573.00
IUUC-Mor-057114 Magnaporthe oryzae 26.00 2.00e-27 117.00
IUUC-Mtr-058367 Medicago truncatula 35.61 3.00e-61 229.00
IUUC-Mla-059107 Melampsora laricipopulina 26.13 3.00e-29 123.00
IUUC-Mga-059745 Meleagris gallopavo 81.88 0.00e+00 704.00
IUUC-Mvi-060362 Microbotryum violaceum 29.46 2.00e-34 140.00
IUUC-Mdo-062257 Monodelphis domestica 82.82 0.00e+00 723.00
IUUC-Mac-065540 Musa acuminata 33.90 3.00e-55 209.00
IUUC-Mpu-066284 Mustela putorius furo 94.33 0.00e+00 784.00
IUUC-Mlu-067241 Myotis lucifugus 93.85 0.00e+00 777.00
IUUC-Nfi-068260 Neosartorya fischeri 28.29 2.00e-36 146.00
IUUC-Ncr-068719 Neurospora crassa 25.68 3.00e-27 116.00
IUUC-Nle-068981 Nomascus leucogenys 93.62 0.00e+00 741.00
IUUC-Opr-071218 Ochotona princeps 85.68 0.00e+00 679.00
IUUC-Ont-071646 Oreochromis niloticus 77.35 0.00e+00 682.00
IUUC-Oan-073453 Ornithorhynchus anatinus 87.94 0.00e+00 768.00
IUUC-Ocu-074008 Oryctolagus cuniculus 94.33 0.00e+00 783.00
IUUC-Oba-075712 Oryza barthii 29.88 8.00e-43 167.00
IUUC-Obr-076721 Oryza brachyantha 34.12 2.00e-58 219.00
IUUC-Ogl-077229 Oryza glaberrima 33.49 6.00e-58 218.00
IUUC-Ogu-078977 Oryza glumaepatula 29.88 3.00e-43 169.00
IUUC-Oin-079683 Oryza indica 33.49 4.00e-58 218.00
IUUC-Olo-080291 Oryza longistaminata 29.73 2.00e-29 122.00
IUUC-Ome-081834 Oryza meridionalis 33.73 4.00e-59 222.00
IUUC-Oni-082507 Oryza nivara 32.61 9.00e-55 207.00
IUUC-Opu-083396 Oryza punctata 33.73 5.00e-59 221.00
IUUC-Oru-085220 Oryza rufipogon 32.85 3.00e-54 206.00
IUUC-Osa-085767 Oryza sativa 33.49 4.00e-58 218.00
IUUC-Ola-087420 Oryzias latipes 77.78 0.00e+00 680.00
IUUC-Olu-087740 Ostreococcus lucimarinus 28.47 4.00e-39 155.00
IUUC-Oga-088264 Otolemur garnettii 92.67 0.00e+00 754.00
IUUC-Oar-089335 Ovis aries 92.91 0.00e+00 773.00
IUUC-Ptr-091320 Pan troglodytes 93.85 0.00e+00 761.00
IUUC-Pan-092833 Papio anubis 93.14 0.00e+00 760.00
IUUC-Psi-093504 Pelodiscus sinensis 85.82 0.00e+00 729.00
IUUC-Pma-094189 Petromyzon marinus 68.40 2.00e-174 605.00
IUUC-Pno-094929 Phaeosphaeria nodorum 27.16 3.00e-34 139.00
IUUC-Ppa-095429 Physcomitrella patens 35.61 7.00e-67 247.00
IUUC-Pfo-096337 Poecilia formosa 75.65 0.00e+00 685.00
IUUC-Pab-097571 Pongo abelii 93.62 0.00e+00 761.00
IUUC-Pop-099977 Populus trichocarpa 35.10 2.00e-64 239.00
IUUC-Pca-100394 Procavia capensis 86.55 0.00e+00 674.00
IUUC-Ppe-101848 Prunus persica 34.38 2.00e-60 226.00
IUUC-Pva-102921 Pteropus vampyrus 90.69 3.00e-116 412.00
IUUC-Pgr-103637 Puccinia graminis 27.93 5.00e-35 142.00
IUUC-Ptt-103781 Puccinia triticina 28.36 5.00e-35 142.00
IUUC-Pte-104135 Pyrenophora teres 26.56 1.00e-33 139.00
IUUC-Pyt-104609 Pyrenophora triticirepentis 26.32 2.00e-31 129.00
IUUC-Rno-105114 Rattus norvegicus 95.51 0.00e+00 790.00
IUUC-Sce-106401 Saccharomyces cerevisiae 29.74 4.00e-41 162.00
IUUC-Sha-107122 Sarcophilus harrisii 84.18 0.00e+00 699.00
IUUC-Sja-107766 Schizosaccharomyces japonicus 31.78 2.00e-49 189.00
IUUC-Spo-108134 Schizosaccharomyces pombe 29.75 1.00e-41 163.00
IUUC-Ssl-108398 Sclerotinia sclerotiorum 28.19 5.00e-37 148.00
IUUC-Smo-108720 Selaginella moellendorffii 34.05 4.00e-59 222.00
IUUC-Sit-110311 Setaria italica 35.13 4.00e-57 215.00
IUUC-Sly-111023 Solanum lycopersicum 31.19 2.00e-53 202.00
IUUC-Stu-112778 Solanum tuberosum 34.13 1.00e-59 223.00
IUUC-Sar-113596 Sorex araneus 77.54 2.00e-173 601.00
IUUC-Sbi-114193 Sorghum bicolor 35.62 3.00e-59 222.00
IUUC-Sre-115002 Sporisorium reilianum 25.66 2.00e-12 67.80
IUUC-Ssc-116066 Sus scrofa 93.62 0.00e+00 776.00
IUUC-Tgu-117048 Taeniopygia guttata 85.11 0.00e+00 655.00
IUUC-Tsy-119573 Tarsius syrichta 60.29 2.00e-132 465.00
IUUC-Tni-119820 Tetraodon nigroviridis 75.77 0.00e+00 679.00
IUUC-Tca-121605 Theobroma cacao 35.34 3.00e-62 232.00
IUUC-Tre-121947 Trichoderma reesei 27.05 8.00e-35 141.00
IUUC-Tvi-122481 Trichoderma virens 27.50 1.00e-36 147.00
IUUC-Tae-125861 Triticum aestivum 32.14 3.00e-57 216.00
IUUC-Tur-126586 Triticum urartu 32.90 6.00e-55 207.00
IUUC-Tme-126900 Tuber melanosporum 33.10 4.00e-52 198.00
IUUC-Tbe-127736 Tupaia belangeri 70.85 3.00e-149 521.00
IUUC-Ttr-129041 Tursiops truncatus 81.09 0.00e+00 660.00
IUUC-Vpa-130260 Vicugna pacos 95.04 0.00e+00 786.00
IUUC-Vvi-131009 Vitis vinifera 33.96 1.00e-60 227.00
IUUC-Xtr-132083 Xenopus tropicalis 79.20 0.00e+00 686.00
IUUC-Xma-133094 Xiphophorus maculatus 74.94 0.00e+00 679.00
IUUC-Yli-134531 Yarrowia lipolytica 25.00 7.00e-21 95.50
IUUC-Zma-135509 Zea mays 34.05 1.00e-59 223.00
Created Date 25-Jun-2017

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