iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046934

UUCD1 version

UUC-HoS-00407

Ensembl Protein ID

ENSP00000386738.3

UniProt Accession

Q9P0J7; Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9UFE8; KCMF1_HUMAN

Genbank Protein ID

BAC43745.1; AAF67009.1; BAB14563.1; BAG37299.1; AAY24192.1; AAX88897.1; AAH00178.1; CAB59274.1

Protein Name

E3 ubiquitin-protein ligase KCMF1; FGF-induced in gastric cancer; Potassium channel modulatory factor; RING-type E3 ubiquitin transferase KCMF1; ZZ-type zinc finger-containing protein 1

Genbank Nucleotide ID

AB083199; AF155652; AK023403; AK314761; AC022210; AC078974; BC000178; AL122115

Gene Name

KCMF1; FIGC; ZZZ1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000176407.17	ENST00000409785.8	ENSP00000386738.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	15581609

Organism

Homo sapiens

Functional Description
(View)

Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.

Protein Sequence
(Fasta)

MSRHEGVSCD ACLKGNFRGR RYKCLICYDY DLCASCYESG ATTTRHTTDH PMQCILTRVD 60
FDLYYGGEAF SVEQPQSFTC PYCGKMGYTE TSLQEHVTSE HAETSTEVIC PICAALPGGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGGGGTG GGCCGGGGGA GGGGAGGAGC GGGATTTGCG GAGCGCCGCG CCGCTGCCGG 60
GAGCCGGCAG GCCCGAGAGT GACCGGAGTC ACGGCGGGCG CCGGCGGAGC TGCGGCGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR023413--GFP-like
IPR013087--Znf_C2H2_type
IPR000433--Znf_ZZ

PROSITE

PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF05605--zf-Di19
PF00569--ZZ

SMART

SM00355--ZnF_C2H2
SM00291--ZnF_ZZ

Gene Ontology

GO:0005576--C:extracellular region
GO:1904813--C:ficolin-1-rich granule lumen
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0043312--P:neutrophil degranulation

KEGG

hsa:56888

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001353	Ailuropoda melanoleuca	96.63	2.00e-162	565.00
IUUC-Apl-003901	Anas platyrhynchos	95.21	1.00e-157	548.00
IUUC-Aca-004248	Anolis carolinensis	97.11	2.00e-168	584.00
IUUC-Ago-007828	Ashbya gossypii	40.35	5.00e-08	52.80
IUUC-Ame-011415	Astyanax mexicanus	87.47	2.00e-154	538.00
IUUC-Bta-013276	Bos taurus	99.20	2.00e-165	575.00
IUUC-Cel-018128	Caenorhabditis elegans	42.28	3.00e-26	113.00
IUUC-Cja-019677	Callithrix jacchus	98.69	2.00e-166	578.00
IUUC-Cfa-020340	Canis familiaris	96.89	7.00e-163	566.00
IUUC-Cpo-022501	Cavia porcellus	97.61	3.00e-163	567.00
IUUC-Cho-024320	Choloepus hoffmanni	97.89	2.00e-165	575.00
IUUC-Cin-025388	Ciona intestinalis	53.98	2.00e-89	322.00
IUUC-Csv-026332	Ciona savignyi	58.53	2.00e-79	289.00
IUUC-Dre-027830	Danio rerio	87.99	5.00e-153	533.00
IUUC-Dno-028990	Dasypus novemcinctus	99.70	3.00e-135	474.00
IUUC-Dor-030302	Dipodomys ordii	100.00	3.00e-45	175.00
IUUC-Dme-031795	Drosophila melanogaster	64.73	5.00e-74	272.00
IUUC-Ete-032538	Echinops telfairi	86.95	1.00e-134	473.00
IUUC-Eca-034000	Equus caballus	96.59	6.00e-161	560.00
IUUC-Fca-035462	Felis catus	96.85	4.00e-170	590.00
IUUC-Fal-036863	Ficedula albicollis	94.85	6.00e-129	453.00
IUUC-Gmo-038498	Gadus morhua	85.28	6.00e-102	364.00
IUUC-Gga-040163	Gallus gallus	94.49	5.00e-153	533.00
IUUC-Gac-042174	Gasterosteus aculeatus	78.77	3.00e-138	484.00
IUUC-Ggo-044452	Gorilla gorilla	97.93	2.00e-167	581.00
IUUC-Itr-048334	Ictidomys tridecemlineatus	96.39	3.00e-94	337.00
IUUC-Lch-049543	Latimeria chalumnae	93.75	5.00e-151	527.00
IUUC-Loc-052359	Lepisosteus oculatus	92.13	6.00e-146	510.00
IUUC-Laf-053512	Loxodonta africana	98.68	1.00e-160	559.00
IUUC-Mcc-055169	Macaca mulatta	99.73	2.00e-169	588.00
IUUC-Meu-056818	Macropus eugenii	100.00	8.00e-83	300.00
IUUC-Mga-059457	Meleagris gallopavo	91.34	1.00e-143	502.00
IUUC-Mmr-061484	Microcebus murinus	87.60	6.00e-138	483.00
IUUC-Mdo-062325	Monodelphis domestica	96.34	2.00e-167	582.00
IUUC-Mmu-063231	Mus musculus	97.38	1.00e-168	585.00
IUUC-Mpu-066640	Mustela putorius furo	71.47	4.00e-130	457.00
IUUC-Mlu-068090	Myotis lucifugus	95.82	2.00e-164	571.00
IUUC-Nle-069910	Nomascus leucogenys	99.73	3.00e-169	587.00
IUUC-Opr-071068	Ochotona princeps	98.40	7.00e-169	586.00
IUUC-Ont-071862	Oreochromis niloticus	79.95	2.00e-143	502.00
IUUC-Oan-072982	Ornithorhynchus anatinus	98.14	2.00e-164	572.00
IUUC-Ocu-074060	Oryctolagus cuniculus	99.09	3.00e-135	474.00
IUUC-Ola-086322	Oryzias latipes	75.13	1.00e-110	393.00
IUUC-Oga-088633	Otolemur garnettii	98.94	4.00e-164	570.00
IUUC-Oar-090084	Ovis aries	98.15	5.00e-163	567.00
IUUC-Ptr-090479	Pan troglodytes	100.00	3.00e-169	587.00
IUUC-Pan-092681	Papio anubis	99.73	3.00e-169	587.00
IUUC-Psi-093474	Pelodiscus sinensis	95.81	1.00e-158	552.00
IUUC-Pma-094419	Petromyzon marinus	63.50	4.00e-114	404.00
IUUC-Ppa-095709	Physcomitrella patens	30.93	9.00e-07	47.00
IUUC-Pfo-096843	Poecilia formosa	78.61	2.00e-130	458.00
IUUC-Pab-098186	Pongo abelii	100.00	4.00e-139	487.00
IUUC-Pca-100929	Procavia capensis	97.35	3.00e-157	547.00
IUUC-Pva-102933	Pteropus vampyrus	97.83	2.00e-135	474.00
IUUC-Rno-105475	Rattus norvegicus	97.07	2.00e-165	575.00
IUUC-Sha-106466	Sarcophilus harrisii	96.33	1.00e-164	572.00
IUUC-Sit-110342	Setaria italica	40.00	3.00e-07	50.10
IUUC-Sar-113598	Sorex araneus	86.05	7.00e-122	430.00
IUUC-Ssc-116196	Sus scrofa	97.92	3.00e-164	571.00
IUUC-Tgu-116780	Taeniopygia guttata	93.63	1.00e-154	538.00
IUUC-Tru-118235	Takifugu rubripes	79.43	9.00e-142	496.00
IUUC-Tsy-118950	Tarsius syrichta	100.00	2.00e-82	299.00
IUUC-Tni-120161	Tetraodon nigroviridis	75.73	9.00e-113	400.00
IUUC-Tbe-128152	Tupaia belangeri	96.55	7.00e-161	560.00
IUUC-Ttr-128348	Tursiops truncatus	98.68	1.00e-164	572.00
IUUC-Vpa-130228	Vicugna pacos	85.04	1.00e-86	312.00
IUUC-Xtr-131931	Xenopus tropicalis	94.49	1.00e-152	532.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence