iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Dme-032076

UUCD1 version

UUC-DrM-00568

Ensembl Protein ID

FBpp0304448

UniProt Accession

M9PBW0; M9PBW0_DROME

Genbank Protein ID

AGB94262.1; AGB94263.1

Protein Name

Ubiquitin conjugating enzyme E2M, isoform B; Ubiquitin conjugating enzyme E2M, isoform C

Genbank Nucleotide ID

AE014296; AE014296

Gene Name

UbcE2M; anon-WO0118547.309; DmelCG7375; dUbc12; Ubc12; UbcD12; ubcD12; CG7375; Dmel_CG7375

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0035853	FBtr0332138	FBpp0304448

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	4.40e-39	133.5	30	162

Active Site

Position(s)	Description	Evidence
108	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           R++k+++el  + p+++  ++ d +dl ++++ i  p++  Y++g F +++++ ++YP +PPkvk+ t+++hPn++ +G+vCl+il+  e+W+p+l++
   Q: 30   RIQKDINEL--NLPNTCATDFPDPNDLLNFKLIIS-PDEGFYRDGRFVFNFRVGSNYPHEPPKVKCATQVYHPNIDLDGNVCLNILR--EDWNPVLNI 122
           89******9..899*****************9998.**************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +s+++++q l+ epnpe+pln+eaa+ l++nr++++++v+
   Q: 123  NSIVYGLQFLFLEPNPEDPLNKEAADVLQTNRRQFENNVK 162
           **************************************98 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MIKLFTLKQQ KKDGEQKGSQ QKKASAAQLR IQKDINELNL PNTCATDFPD PNDLLNFKLI 60
ISPDEGFYRD GRFVFNFRVG SNYPHEPPKV KCATQVYHPN IDLDGNVCLN ILREDWNPVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGGTTTTAA AATTTTCTTC GTTTCGAAGT ATCCAAACTT GGCTTGAATC CCGCTGAATC 60
CGAAGTCCGC TTACCAGCAC TACGCAACAA CTATCGAGCA GACTGTTATC GGGTGCAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0016874--F:ligase activity

KEGG

dme:Dmel_CG7375

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000196	Aegilops tauschii	55.29	2.00e-50	190.00
IUUC-Aml-002007	Ailuropoda melanoleuca	76.71	5.00e-67	245.00
IUUC-Atr-003170	Amborella trichopoda	56.83	8.00e-60	221.00
IUUC-Aca-005037	Anolis carolinensis	75.27	4.00e-80	289.00
IUUC-Aly-006219	Arabidopsis lyrata	60.00	3.00e-62	230.00
IUUC-Ath-006876	Arabidopsis thaliana	57.61	4.00e-61	226.00
IUUC-Ago-007910	Ashbya gossypii	47.97	3.00e-38	150.00
IUUC-Acl-008364	Aspergillus clavatus	63.38	5.00e-54	202.00
IUUC-Afl-008463	Aspergillus flavus	58.94	7.00e-54	202.00
IUUC-Afu-008803	Aspergillus fumigatus	60.93	4.00e-55	206.00
IUUC-Ani-009422	Aspergillus nidulans	58.94	5.00e-53	199.00
IUUC-Ang-009728	Aspergillus niger	62.12	8.00e-49	184.00
IUUC-Aor-009962	Aspergillus oryzae	58.94	7.00e-54	202.00
IUUC-Ate-010430	Aspergillus terreus	57.96	2.00e-49	187.00
IUUC-Ame-011382	Astyanax mexicanus	76.63	2.00e-81	293.00
IUUC-Bgr-012306	Blumeria graminis	60.34	1.00e-61	227.00
IUUC-Bta-012818	Bos taurus	75.27	2.00e-80	290.00
IUUC-Bci-013626	Botrytis cinerea	55.74	1.00e-58	218.00
IUUC-Bdi-014528	Brachypodium distachyon	58.24	6.00e-58	215.00
IUUC-Bol-015929	Brassica oleracea	62.20	5.00e-59	219.00
IUUC-Bra-017161	Brassica rapa	62.80	1.00e-59	221.00
IUUC-Cja-019213	Callithrix jacchus	73.26	4.00e-78	282.00
IUUC-Cfa-020242	Canis familiaris	74.46	8.00e-79	285.00
IUUC-Cpo-022405	Cavia porcellus	71.98	2.00e-75	273.00
IUUC-Cre-022865	Chlamydomonas reinhardtii	60.81	7.00e-51	192.00
IUUC-Csa-023269	Chlorocebus sabaeus	75.27	2.00e-80	290.00
IUUC-Cin-025333	Ciona intestinalis	69.78	8.00e-75	271.00
IUUC-Csv-025898	Ciona savignyi	58.14	1.00e-68	251.00
IUUC-Cgl-026477	Colletotrichum gloeosporioides	54.40	3.00e-57	213.00
IUUC-Cne-027097	Cryptococcus neoformans	60.57	3.00e-62	229.00
IUUC-Cme-027287	Cyanidioschyzon merolae	51.35	6.00e-19	86.30
IUUC-Dre-028514	Danio rerio	73.37	4.00e-76	276.00
IUUC-Dno-029678	Dasypus novemcinctus	68.68	3.00e-72	263.00
IUUC-Dor-030851	Dipodomys ordii	51.81	8.00e-40	155.00
IUUC-Dse-031265	Dothistroma septosporum	57.63	2.00e-61	227.00
IUUC-Ete-032350	Echinops telfairi	53.51	1.00e-31	127.00
IUUC-Eca-034075	Equus caballus	74.18	5.00e-79	285.00
IUUC-Fca-035654	Felis catus	76.71	5.00e-67	245.00
IUUC-Fal-037283	Ficedula albicollis	71.08	2.00e-33	132.00
IUUC-Fox-037877	Fusarium oxysporum	58.33	7.00e-58	215.00
IUUC-Fso-038428	Fusarium solani	57.78	8.00e-63	231.00
IUUC-Gmo-039402	Gadus morhua	76.63	7.00e-82	295.00
IUUC-Ggr-039731	Gaeumannomyces graminis	53.01	9.00e-57	211.00
IUUC-Gga-041122	Gallus gallus	70.06	2.00e-72	264.00
IUUC-Gac-041480	Gasterosteus aculeatus	36.11	4.00e-28	116.00
IUUC-Gma-043805	Glycine max	57.38	6.00e-60	222.00
IUUC-Ggo-044436	Gorilla gorilla	75.27	2.00e-80	290.00
IUUC-Hsa-046026	Homo sapiens	75.27	2.00e-80	290.00
IUUC-Hvu-047056	Hordeum vulgare	57.69	8.00e-57	211.00
IUUC-Itr-047889	Ictidomys tridecemlineatus	75.27	2.00e-80	290.00
IUUC-Kpa-049315	Komagataella pastoris	51.41	6.00e-49	185.00
IUUC-Lch-050360	Latimeria chalumnae	62.35	3.00e-50	190.00
IUUC-Lpe-050743	Leersia perrieri	58.72	2.00e-57	214.00
IUUC-Loc-052137	Lepisosteus oculatus	37.43	7.00e-28	115.00
IUUC-Lma-053001	Leptosphaeria maculans	59.62	3.00e-55	206.00
IUUC-Laf-053463	Loxodonta africana	76.71	6.00e-67	244.00
IUUC-Mcc-054966	Macaca mulatta	78.21	7.00e-36	140.00
IUUC-Meu-056085	Macropus eugenii	76.55	4.00e-66	242.00
IUUC-Mor-057250	Magnaporthe oryzae	61.59	5.00e-56	209.00
IUUC-Mpo-057481	Magnaporthe poae	60.93	2.00e-54	204.00
IUUC-Mtr-058251	Medicago truncatula	57.38	2.00e-60	223.00
IUUC-Mla-059119	Melampsora laricipopulina	58.10	1.00e-62	231.00
IUUC-Mga-059881	Meleagris gallopavo	73.58	7.00e-46	174.00
IUUC-Mvi-060449	Microbotryum violaceum	56.25	6.00e-57	212.00
IUUC-Mmr-061511	Microcebus murinus	78.21	4.00e-36	141.00
IUUC-Mdo-061993	Monodelphis domestica	38.12	1.00e-28	119.00
IUUC-Mmu-063962	Mus musculus	75.27	2.00e-80	290.00
IUUC-Mac-064967	Musa acuminata	59.56	2.00e-62	231.00
IUUC-Mpu-066423	Mustela putorius furo	43.80	1.00e-28	118.00
IUUC-Mlu-066955	Myotis lucifugus	75.33	3.00e-67	246.00
IUUC-Nfi-068300	Neosartorya fischeri	60.93	4.00e-55	206.00
IUUC-Ncr-068944	Neurospora crassa	55.56	4.00e-58	216.00
IUUC-Nle-069051	Nomascus leucogenys	76.71	5.00e-67	245.00
IUUC-Opr-070635	Ochotona princeps	76.55	2.00e-66	243.00
IUUC-Ont-072348	Oreochromis niloticus	76.09	2.00e-81	293.00
IUUC-Ocu-074905	Oryctolagus cuniculus	75.27	2.00e-80	290.00
IUUC-Oba-075825	Oryza barthii	58.24	1.00e-60	224.00
IUUC-Obr-076067	Oryza brachyantha	58.24	2.00e-60	224.00
IUUC-Ogl-077594	Oryza glaberrima	58.24	1.00e-60	224.00
IUUC-Ogu-078073	Oryza glumaepatula	58.24	1.00e-60	224.00
IUUC-Oin-080060	Oryza indica	57.38	6.00e-58	217.00
IUUC-Olo-080314	Oryza longistaminata	58.24	7.00e-61	225.00
IUUC-Ome-081713	Oryza meridionalis	58.24	2.00e-60	224.00
IUUC-Oni-082426	Oryza nivara	58.24	1.00e-60	224.00
IUUC-Opu-083942	Oryza punctata	58.72	1.00e-57	214.00
IUUC-Oru-085104	Oryza rufipogon	58.24	1.00e-60	224.00
IUUC-Osa-086168	Oryza sativa	58.24	1.00e-60	224.00
IUUC-Olu-087854	Ostreococcus lucimarinus	54.35	2.00e-55	207.00
IUUC-Oga-088580	Otolemur garnettii	75.27	2.00e-80	290.00
IUUC-Oar-089623	Ovis aries	70.75	4.00e-59	219.00
IUUC-Ptr-091161	Pan troglodytes	67.40	4.00e-70	256.00
IUUC-Pan-092119	Papio anubis	76.71	5.00e-67	245.00
IUUC-Psi-093494	Pelodiscus sinensis	76.71	1.00e-66	244.00
IUUC-Pma-094321	Petromyzon marinus	46.15	3.00e-24	103.00
IUUC-Pno-094972	Phaeosphaeria nodorum	57.93	3.00e-54	203.00
IUUC-Ppa-095187	Physcomitrella patens	62.64	1.00e-64	238.00
IUUC-Pfo-097205	Poecilia formosa	72.58	1.00e-74	270.00
IUUC-Pab-098434	Pongo abelii	75.27	2.00e-80	290.00
IUUC-Pop-099789	Populus trichocarpa	58.47	1.00e-60	224.00
IUUC-Pca-100300	Procavia capensis	76.55	3.00e-66	243.00
IUUC-Ppe-101216	Prunus persica	57.92	2.00e-53	200.00
IUUC-Pva-102143	Pteropus vampyrus	75.27	2.00e-80	290.00
IUUC-Pgr-103675	Puccinia graminis	56.91	9.00e-62	229.00
IUUC-Ptt-103997	Puccinia triticina	56.91	2.00e-62	230.00
IUUC-Pte-104042	Pyrenophora teres	60.26	4.00e-56	209.00
IUUC-Pyt-104616	Pyrenophora triticirepentis	60.27	3.00e-52	196.00
IUUC-Rno-105107	Rattus norvegicus	75.27	2.00e-80	290.00
IUUC-Sce-106385	Saccharomyces cerevisiae	44.71	4.00e-40	156.00
IUUC-Sha-106899	Sarcophilus harrisii	76.71	2.00e-66	243.00
IUUC-Sja-107789	Schizosaccharomyces japonicus	51.40	2.00e-53	200.00
IUUC-Spo-108143	Schizosaccharomyces pombe	52.51	4.00e-53	199.00
IUUC-Ssl-108427	Sclerotinia sclerotiorum	56.35	1.00e-59	221.00
IUUC-Smo-108673	Selaginella moellendorffii	60.33	1.00e-63	234.00
IUUC-Sit-109702	Setaria italica	65.16	2.00e-58	217.00
IUUC-Sly-111650	Solanum lycopersicum	60.11	8.00e-63	231.00
IUUC-Stu-112655	Solanum tuberosum	59.02	1.00e-62	231.00
IUUC-Sar-113632	Sorex araneus	74.73	2.00e-79	287.00
IUUC-Sbi-114357	Sorghum bicolor	64.52	2.00e-58	217.00
IUUC-Sre-114912	Sporisorium reilianum	60.39	5.00e-57	212.00
IUUC-Ssc-115597	Sus scrofa	38.12	4.00e-28	116.00
IUUC-Tgu-117397	Taeniopygia guttata	38.29	2.00e-28	117.00
IUUC-Tru-118496	Takifugu rubripes	35.91	8.00e-28	115.00
IUUC-Tsy-119639	Tarsius syrichta	59.73	2.00e-46	177.00
IUUC-Tni-119674	Tetraodon nigroviridis	61.96	2.00e-61	227.00
IUUC-Tca-121359	Theobroma cacao	57.92	2.00e-60	224.00
IUUC-Tre-122115	Trichoderma reesei	62.89	7.00e-60	222.00
IUUC-Tvi-122656	Trichoderma virens	61.01	1.00e-57	214.00
IUUC-Tae-124489	Triticum aestivum	57.69	8.00e-57	211.00
IUUC-Tur-126125	Triticum urartu	57.69	3.00e-56	211.00
IUUC-Tme-126950	Tuber melanosporum	63.46	3.00e-57	213.00
IUUC-Tbe-127874	Tupaia belangeri	54.40	5.00e-47	179.00
IUUC-Ttr-128213	Tursiops truncatus	74.07	4.00e-69	252.00
IUUC-Uma-129329	Ustilago maydis	61.04	3.00e-58	216.00
IUUC-Vda-129754	Verticillium dahliae	59.62	8.00e-56	208.00
IUUC-Vvi-131182	Vitis vinifera	57.92	5.00e-60	223.00
IUUC-Xtr-132742	Xenopus tropicalis	74.73	1.00e-79	288.00
IUUC-Xma-133558	Xiphophorus maculatus	73.37	6.00e-76	275.00
IUUC-Yli-134467	Yarrowia lipolytica	56.91	7.00e-63	231.00
IUUC-Zma-135527	Zea mays	63.23	3.00e-57	213.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence