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Tag Content
UUCD2 ID IUUC-Cfa-020736
UUCD1 version UUC-CaF-00572
Ensembl Protein ID ENSCAFP00000024966.3
UniProt Accession F1P920; F1P920_CANLF
Genbank Protein ID ENSCAFP00000024966
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAEX03005850
Gene Name AREL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000016962.3 ENSCAFT00000026863.3 ENSCAFP00000024966.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.10e-102 342.0 476 813
Active Site
Position(s) Description Evidence
781 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n+++ ++pnp++  +   +lk++ef+Grl+gk+l+++     
   Q: 476  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFtRFSDNNQALVHPNPNRPAH--LRLKMYEFAGRLVGKCLYESslgga 562
           7999**************************************888999***********975..9******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k++eL++gG+++pVtn+Nk 
   Q: 563  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKI 648
           99***********************************99****99...9****9****9999999************************ PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl +++ke+ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v++++++e
   Q: 649  FYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAvVVGGSWHFREKVMRWFWTVVSSLTQE 737
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 738  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGcEGFGM 813
           ************************99555555.**************************************9***97 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
SLVYIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HVRECFCLHT HWVFFLELAV EIPVTQEVLQ EPRSNVVKVA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020736|E3,HECT|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCTCTCGTTT ACATAGGTGG GATCACAGTG TCTGTGGTTG CATTCTTCTT CACAATTAAG 60
TTCCTCTTTG AGCTTGCCGC ACGGGTTGTC AGCTTCCTCC AGAATGAGGA CCGTGAGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020736|E3,HECT|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT
Pfam

PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001308 Ailuropoda melanoleuca 96.59 0.00e+00 1546.00
IUUC-Apl-004071 Anas platyrhynchos 89.44 0.00e+00 1397.00
IUUC-Aca-005218 Anolis carolinensis 89.40 0.00e+00 1416.00
IUUC-Ame-011871 Astyanax mexicanus 77.52 0.00e+00 1297.00
IUUC-Bta-012978 Bos taurus 95.00 0.00e+00 1522.00
IUUC-Cja-019081 Callithrix jacchus 95.37 0.00e+00 1529.00
IUUC-Cpo-021581 Cavia porcellus 94.76 0.00e+00 1523.00
IUUC-Csa-024189 Chlorocebus sabaeus 91.18 0.00e+00 804.00
IUUC-Cho-024751 Choloepus hoffmanni 94.27 0.00e+00 1464.00
IUUC-Cin-025773 Ciona intestinalis 42.64 2.00e-147 516.00
IUUC-Csv-026090 Ciona savignyi 39.88 9.00e-166 577.00
IUUC-Dre-027788 Danio rerio 78.37 0.00e+00 1301.00
IUUC-Dno-030022 Dasypus novemcinctus 95.25 0.00e+00 1524.00
IUUC-Dme-031577 Drosophila melanogaster 46.95 0.00e+00 708.00
IUUC-Ete-032402 Echinops telfairi 92.20 0.00e+00 1452.00
IUUC-Eca-033908 Equus caballus 96.22 0.00e+00 1541.00
IUUC-Eeu-034869 Erinaceus europaeus 98.27 0.00e+00 925.00
IUUC-Fca-036023 Felis catus 96.46 0.00e+00 1543.00
IUUC-Fal-037477 Ficedula albicollis 89.88 0.00e+00 1449.00
IUUC-Gmo-039197 Gadus morhua 78.37 0.00e+00 1280.00
IUUC-Gga-040704 Gallus gallus 90.00 0.00e+00 1440.00
IUUC-Gac-041511 Gasterosteus aculeatus 77.04 0.00e+00 1288.00
IUUC-Ggo-044527 Gorilla gorilla 91.84 0.00e+00 1453.00
IUUC-Hsa-046082 Homo sapiens 95.37 0.00e+00 1530.00
IUUC-Itr-048168 Ictidomys tridecemlineatus 95.49 0.00e+00 1533.00
IUUC-Lch-049772 Latimeria chalumnae 74.57 0.00e+00 1165.00
IUUC-Loc-052541 Lepisosteus oculatus 79.42 0.00e+00 1322.00
IUUC-Laf-053852 Loxodonta africana 95.12 0.00e+00 1521.00
IUUC-Mcc-054759 Macaca mulatta 91.40 0.00e+00 719.00
IUUC-Meu-056247 Macropus eugenii 74.54 0.00e+00 771.00
IUUC-Mga-060161 Meleagris gallopavo 89.65 0.00e+00 1435.00
IUUC-Mmr-061447 Microcebus murinus 95.49 0.00e+00 1529.00
IUUC-Mdo-062110 Monodelphis domestica 92.07 0.00e+00 1446.00
IUUC-Mmu-064349 Mus musculus 94.39 0.00e+00 1521.00
IUUC-Mpu-065824 Mustela putorius furo 96.10 0.00e+00 1541.00
IUUC-Mlu-067729 Myotis lucifugus 95.49 0.00e+00 1523.00
IUUC-Nle-069721 Nomascus leucogenys 94.88 0.00e+00 1519.00
IUUC-Opr-070189 Ochotona princeps 94.87 0.00e+00 1521.00
IUUC-Ont-072122 Oreochromis niloticus 78.61 0.00e+00 1282.00
IUUC-Oan-072700 Ornithorhynchus anatinus 82.04 0.00e+00 1177.00
IUUC-Ocu-074057 Oryctolagus cuniculus 95.24 0.00e+00 1526.00
IUUC-Ola-087492 Oryzias latipes 77.86 0.00e+00 1289.00
IUUC-Oga-088084 Otolemur garnettii 95.49 0.00e+00 1524.00
IUUC-Oar-090354 Ovis aries 95.07 0.00e+00 1502.00
IUUC-Ptr-091456 Pan troglodytes 95.12 0.00e+00 1525.00
IUUC-Pan-092596 Papio anubis 93.91 0.00e+00 1498.00
IUUC-Psi-092942 Pelodiscus sinensis 90.72 0.00e+00 1446.00
IUUC-Pma-094662 Petromyzon marinus 62.04 0.00e+00 754.00
IUUC-Pfo-096838 Poecilia formosa 78.49 0.00e+00 1273.00
IUUC-Pab-097849 Pongo abelii 94.88 0.00e+00 1523.00
IUUC-Pca-100498 Procavia capensis 91.53 0.00e+00 825.00
IUUC-Pva-102599 Pteropus vampyrus 95.61 0.00e+00 1532.00
IUUC-Rno-105776 Rattus norvegicus 94.88 0.00e+00 1523.00
IUUC-Sha-106699 Sarcophilus harrisii 92.32 0.00e+00 1454.00
IUUC-Sar-113621 Sorex araneus 93.61 0.00e+00 1492.00
IUUC-Ssc-115742 Sus scrofa 95.73 0.00e+00 1534.00
IUUC-Tgu-116490 Taeniopygia guttata 89.51 0.00e+00 1446.00
IUUC-Tru-117679 Takifugu rubripes 77.76 0.00e+00 1272.00
IUUC-Tsy-119607 Tarsius syrichta 94.06 0.00e+00 1096.00
IUUC-Tni-120376 Tetraodon nigroviridis 74.37 0.00e+00 1194.00
IUUC-Tbe-127348 Tupaia belangeri 67.52 4.00e-180 624.00
IUUC-Ttr-128786 Tursiops truncatus 92.07 0.00e+00 1461.00
IUUC-Vpa-130180 Vicugna pacos 94.29 0.00e+00 1212.00
IUUC-Xtr-132631 Xenopus tropicalis 66.02 0.00e+00 1080.00
Created Date 25-Jun-2017

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