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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063290
UUCD1 version UUC-MuM-00794
Ensembl Protein ID ENSMUSP00000057849.4
UniProt Accession Q8R5B6; Q8BJI9; Q8VHS8; SPSB4_MOUSE
Genbank Protein ID AAL57358.2; BAC38995.1; BAE24972.1; AAH23083.1; AAH55705.1; AAH94332.1
Protein Name SPRY domain-containing SOCS box protein 4
Genbank Nucleotide ID AF403039; AK083698; AK142195; BC023083; BC055705; BC094332
Gene Name Spsb4; Ssb4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000046997.5 ENSMUST00000055433.4 ENSMUSP00000057849.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.30e-16 61.3 230 273
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 7    lrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           l  ep +L++LCR++Ir++lg+qrl++i  LPLP+sLk+YL+y+
   Q: 230  LDPEPLPLMDLCRRSIRSALGRQRLRDIGSLPLPQSLKNYLQYQ 273
           5679**************************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MGQKLSGSLK SVEVREPALR PAKRELRGLE PGRPARLDQL LDMPAAGLAV QLRHAWNPED 60
RSLNVFVKDD DRLTFHRHPV AQSTDGIRGK VGHARGLHAW QIHWPARQRG THAVVGVATA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063290|E3,SOCS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGGATCGGC TTTCAGCTGC AGCCTCCGGG CCGGCCGGGA AGGCGGGGAG CGAGCGGCCG 60
TGGAGGAGGA GGGGGAGGCG GCGGCTGCAG CATCCAGAGC TGGCCCTGGC GGTCGGCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063290|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom
PROSITE

PS50188--B302_SPRY
PS50225--SOCS
Pfam

PF07525--SOCS_box
PF00622--SPRY
SMART

SM00969--SOCS_box
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG mmu:211949
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001823 Ailuropoda melanoleuca 96.34 1.00e-153 535.00
IUUC-Aca-004723 Anolis carolinensis 82.05 1.00e-134 472.00
IUUC-Ame-010730 Astyanax mexicanus 77.98 3.00e-118 417.00
IUUC-Bta-012654 Bos taurus 97.07 5.00e-155 540.00
IUUC-Cel-018566 Caenorhabditis elegans 54.65 8.00e-79 287.00
IUUC-Cja-019343 Callithrix jacchus 97.07 5.00e-155 540.00
IUUC-Cfa-020061 Canis familiaris 96.34 4.00e-154 536.00
IUUC-Cpo-021975 Cavia porcellus 96.34 8.00e-153 532.00
IUUC-Csa-023630 Chlorocebus sabaeus 98.24 5.00e-131 459.00
IUUC-Cho-024458 Choloepus hoffmanni 92.41 9.00e-76 276.00
IUUC-Dre-028237 Danio rerio 78.70 6.00e-120 423.00
IUUC-Ete-033077 Echinops telfairi 94.87 3.00e-151 527.00
IUUC-Eca-033453 Equus caballus 94.53 5.00e-149 520.00
IUUC-Fal-036622 Ficedula albicollis 82.05 2.00e-134 471.00
IUUC-Gmo-038808 Gadus morhua 76.26 7.00e-120 423.00
IUUC-Gga-040436 Gallus gallus 81.68 1.00e-134 472.00
IUUC-Ggo-045156 Gorilla gorilla 97.80 3.00e-156 543.00
IUUC-Hsa-046998 Homo sapiens 97.80 3.00e-156 543.00
IUUC-Itr-048821 Ictidomys tridecemlineatus 98.27 3.00e-132 463.00
IUUC-Lch-050022 Latimeria chalumnae 81.06 4.00e-123 433.00
IUUC-Loc-051943 Lepisosteus oculatus 82.05 2.00e-135 474.00
IUUC-Laf-053747 Loxodonta africana 93.04 3.00e-147 514.00
IUUC-Meu-056163 Macropus eugenii 85.35 4.00e-137 480.00
IUUC-Mmr-061796 Microcebus murinus 97.80 5.00e-156 543.00
IUUC-Mdo-062070 Monodelphis domestica 84.98 1.00e-136 478.00
IUUC-Mpu-066192 Mustela putorius furo 97.07 8.00e-155 539.00
IUUC-Mlu-067789 Myotis lucifugus 94.12 1.00e-130 458.00
IUUC-Nle-069241 Nomascus leucogenys 97.07 4.00e-155 540.00
IUUC-Ont-071823 Oreochromis niloticus 78.06 4.00e-121 427.00
IUUC-Oan-072734 Ornithorhynchus anatinus 82.05 4.00e-135 473.00
IUUC-Ola-087207 Oryzias latipes 76.26 2.00e-117 415.00
IUUC-Oga-089170 Otolemur garnettii 86.72 2.00e-136 477.00
IUUC-Ptr-090656 Pan troglodytes 97.80 3.00e-156 543.00
IUUC-Pan-092077 Papio anubis 98.17 8.00e-157 545.00
IUUC-Psi-093552 Pelodiscus sinensis 83.52 2.00e-136 478.00
IUUC-Pma-094441 Petromyzon marinus 53.11 3.00e-80 291.00
IUUC-Pfo-096646 Poecilia formosa 78.78 1.00e-121 429.00
IUUC-Pab-098256 Pongo abelii 97.07 1.00e-155 541.00
IUUC-Pca-100533 Procavia capensis 97.27 8.00e-104 369.00
IUUC-Pva-102621 Pteropus vampyrus 96.70 3.00e-154 536.00
IUUC-Rno-105152 Rattus norvegicus 100.00 4.00e-159 553.00
IUUC-Sha-107522 Sarcophilus harrisii 84.98 2.00e-136 478.00
IUUC-Sar-113664 Sorex araneus 95.60 6.00e-153 532.00
IUUC-Ssc-115430 Sus scrofa 97.80 1.00e-156 545.00
IUUC-Tgu-116552 Taeniopygia guttata 81.68 6.00e-134 469.00
IUUC-Tru-118631 Takifugu rubripes 74.48 2.00e-113 401.00
IUUC-Tsy-119192 Tarsius syrichta 98.27 1.00e-131 461.00
IUUC-Tni-120160 Tetraodon nigroviridis 77.74 3.00e-112 397.00
IUUC-Tae-124746 Triticum aestivum 45.45 4.10e-01 30.00
IUUC-Ttr-128238 Tursiops truncatus 97.44 3.00e-154 537.00
Created Date 25-Jun-2017

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