iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000013045.1	ENSSHAT00000015429.1	ENSSHAP00000015302.1
ENSSHAG00000013045.1	ENSSHAT00000015430.1	ENSSHAP00000015303.1
ENSSHAG00000013045.1	ENSSHAT00000015431.1	ENSSHAP00000015304.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.80e-120	400.2	2162	2624

Active Site

Position(s)	Description	Evidence
2593	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg +l++++  d+e+++++   glk+p                     
   Q: 2162 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTELGTWLCDDDfpDDESRHVDLGGGLKPPgyyvqrscglftapfpqdsde 2247
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2248 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 2334
           *************************************99999999999999999999999999999999999999988888888887 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+
   Q: 2335 sefildppkpkppawFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilgnkslsedekntklqdlmlknpsgsgpplSIEDLGLN 2421
           7777777777766666668***********************9334455555666777788899999999999************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafr....eGfneviplellslFteeelellicGe 221
           ++f++s++++g t+++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr    +Gfn+v+p+e+ls+F++ee+++++cG+
   Q: 2422 FQFCPSSRVYGFTAVD-LKPRGEDEMITMDNAEEYVDLMFDFCMQTGIQKQMEAFRgndkDGFNKVFPMEKLSSFSHEEVQMILCGN 2507
           *************999.**************************************766669************************** PP
   S: 222  eeidvedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssn 302
              +++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+n
   Q: 2508 ---QSPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVN 2591
           ...6666666665555555******************************************************************** PP
   S: 303  TCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           TC++yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2592 TCVHYLKLPEYSSEEIMRERLLAATME-KGFHLN 2624
           ***************************.****86 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGATG TGGACCCAGA TACATTGTTG GAATGGCTAC AGATGGGGCA GGGAGATGAA 60
AGGGACATGC AACTAATAGC CCTTGAACAG CTATGTATGC TGCTTTTGAT GTCTGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	95.62	0.00e+00	4484.00
IUUC-Apl-003493	Anas platyrhynchos	95.68	0.00e+00	4505.00
IUUC-Aca-004521	Anolis carolinensis	96.02	0.00e+00	2789.00
IUUC-Ame-011258	Astyanax mexicanus	90.58	0.00e+00	2360.00
IUUC-Bta-012835	Bos taurus	95.62	0.00e+00	4499.00
IUUC-Cel-018153	Caenorhabditis elegans	52.30	7.00e-169	589.00
IUUC-Cja-019174	Callithrix jacchus	95.20	0.00e+00	4448.00
IUUC-Cfa-021115	Canis familiaris	95.54	0.00e+00	4446.00
IUUC-Cpo-022382	Cavia porcellus	91.83	0.00e+00	4270.00
IUUC-Csa-023230	Chlorocebus sabaeus	95.81	0.00e+00	4496.00
IUUC-Cho-024711	Choloepus hoffmanni	93.97	0.00e+00	1619.00
IUUC-Cin-025342	Ciona intestinalis	53.05	0.00e+00	1369.00
IUUC-Csv-026031	Ciona savignyi	51.89	0.00e+00	1407.00
IUUC-Dre-027435	Danio rerio	87.55	0.00e+00	4130.00
IUUC-Dno-029954	Dasypus novemcinctus	95.66	0.00e+00	4460.00
IUUC-Dor-030734	Dipodomys ordii	92.68	0.00e+00	1410.00
IUUC-Dme-031739	Drosophila melanogaster	59.74	0.00e+00	1619.00
IUUC-Ete-033192	Echinops telfairi	98.44	0.00e+00	704.00
IUUC-Eca-033434	Equus caballus	95.73	0.00e+00	4490.00
IUUC-Eeu-035031	Erinaceus europaeus	83.90	2.00e-170	592.00
IUUC-Fca-035998	Felis catus	94.05	0.00e+00	4378.00
IUUC-Fal-037468	Ficedula albicollis	95.40	0.00e+00	2796.00
IUUC-Gmo-038495	Gadus morhua	90.62	0.00e+00	1366.00
IUUC-Gga-040736	Gallus gallus	97.15	0.00e+00	2802.00
IUUC-Gac-041777	Gasterosteus aculeatus	90.99	0.00e+00	2385.00
IUUC-Ggo-044677	Gorilla gorilla	91.72	0.00e+00	4232.00
IUUC-Hsa-045879	Homo sapiens	95.81	0.00e+00	4496.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	95.69	0.00e+00	4492.00
IUUC-Lch-050444	Latimeria chalumnae	91.60	0.00e+00	4182.00
IUUC-Loc-051986	Lepisosteus oculatus	88.25	0.00e+00	4153.00
IUUC-Laf-054230	Loxodonta africana	95.85	0.00e+00	4454.00
IUUC-Mcc-054787	Macaca mulatta	95.81	0.00e+00	4496.00
IUUC-Meu-056502	Macropus eugenii	90.81	0.00e+00	1342.00
IUUC-Mga-059409	Meleagris gallopavo	91.23	0.00e+00	2092.00
IUUC-Mmr-061667	Microcebus murinus	95.40	0.00e+00	4472.00
IUUC-Mdo-061960	Monodelphis domestica	97.37	0.00e+00	4576.00
IUUC-Mmu-063941	Mus musculus	95.43	0.00e+00	4482.00
IUUC-Mpu-065939	Mustela putorius furo	95.69	0.00e+00	4496.00
IUUC-Mlu-068112	Myotis lucifugus	95.50	0.00e+00	4454.00
IUUC-Nle-069001	Nomascus leucogenys	95.73	0.00e+00	4496.00
IUUC-Opr-071222	Ochotona princeps	92.85	0.00e+00	2074.00
IUUC-Ont-072101	Oreochromis niloticus	81.52	0.00e+00	3905.00
IUUC-Oan-072814	Ornithorhynchus anatinus	96.30	0.00e+00	4498.00
IUUC-Ocu-074011	Oryctolagus cuniculus	95.62	0.00e+00	4487.00
IUUC-Ola-086412	Oryzias latipes	90.91	0.00e+00	2378.00
IUUC-Oar-089668	Ovis aries	95.69	0.00e+00	4496.00
IUUC-Ptr-090517	Pan troglodytes	95.69	0.00e+00	4471.00
IUUC-Pan-091849	Papio anubis	93.18	0.00e+00	4323.00
IUUC-Psi-093390	Pelodiscus sinensis	93.82	0.00e+00	2703.00
IUUC-Pma-094628	Petromyzon marinus	83.40	0.00e+00	1567.00
IUUC-Pfo-097075	Poecilia formosa	84.22	0.00e+00	2605.00
IUUC-Pab-098176	Pongo abelii	95.81	0.00e+00	4496.00
IUUC-Pca-101123	Procavia capensis	89.94	0.00e+00	2368.00
IUUC-Pva-103008	Pteropus vampyrus	89.45	0.00e+00	1794.00
IUUC-Rno-105885	Rattus norvegicus	95.24	0.00e+00	4472.00
IUUC-Sar-113071	Sorex araneus	93.21	0.00e+00	1268.00
IUUC-Ssc-115963	Sus scrofa	95.31	0.00e+00	4473.00
IUUC-Tgu-117167	Taeniopygia guttata	94.31	0.00e+00	2638.00
IUUC-Tru-118626	Takifugu rubripes	81.80	0.00e+00	3945.00
IUUC-Tsy-119504	Tarsius syrichta	94.39	0.00e+00	2258.00
IUUC-Tni-119877	Tetraodon nigroviridis	91.38	0.00e+00	2407.00
IUUC-Tbe-127602	Tupaia belangeri	96.51	0.00e+00	989.00
IUUC-Ttr-128394	Tursiops truncatus	93.96	0.00e+00	2991.00
IUUC-Vpa-130280	Vicugna pacos	95.04	0.00e+00	4280.00
IUUC-Xtr-131787	Xenopus tropicalis	86.31	0.00e+00	2565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence