iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106525

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01211545

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000004501.1	ENSSHAT00000005198.1	ENSSHAP00000005147.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-86	291.0	716	1035

Active Site

Position(s)	Description	Evidence
1006	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           +dlkk+l v+f++E g d+gGv + f++ +++e+ +p++++f+y e+++ +++p + ++    ++ ++F f G+l+g+++++g++ +
   Q: 716  NDLKKELLVSFTKEIGPDYGGVRKAFFHYVFEEMIHPKYEMFMYCEESSLMWFPPSPKF----DKKNYFLF-GILCGLSIVNGNVAN 797
           799***************************************************99998....88999955.*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           lp++ ++yk+ll++klsledl+e+ p++ k  lk +++ + ++ie+  + +++          k+++L+p+G+++ V+++N++++++
   Q: 798  LPFPLALYKKLLNQKLSLEDLQELSPKFGKDnLKLLLDENAKSIEDFLMYFSI------HWVGKDVDLIPNGSSVLVNKTNRKDFIS 878
           ******************************99*****9988888886554444......46778899******************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++++y+l++++++ +++f +Gf++v+++e+l+ F++eel+ ++ G++e+d+++++++ +y++gy +++p+i +Fw++++++s e++k
   Q: 879  KYINYILNTSVEKIYKEFERGFYKVCEKEILNFFHPEELREVMTGNPEYDWKKFEENSEYHHGYCKSHPTIVMFWDAFHRLSLEQKK 965
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           +fL F+Tgs+r  ++G+++   ++f+    +++++ P+++TCfn L LP+Ys+++ ++e L++Ai+++kgF
   Q: 966  KFLLFLTGSDRFQARGVENSGIKFFCPDS-SREEDPPKAQTCFNILYLPKYSTMKRMEEALQTAIRNNKGF 1035
           *********************77666666.999*************************************9 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MYYCWGDNSF RQLGINAGRR ASPRVVRCRE GASLGGQQIV QAACGERHSL LLLADGTVWS 60
CGNNSYGQLG RKNIKKSKRP APIQALETQV VVSVSCGKEH SLAICKTGRI YSWGSGSRGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACTACT GCTGGGGGGA CAACTCCTTC AGGCAGCTGG GCATCAACGC AGGGCGGAGG 60
GCCAGTCCTA GGGTGGTGAG ATGCCGGGAG GGAGCCAGCC TCGGCGGCCA GCAGATAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	53.03	0.00e+00	947.00
IUUC-Aca-004663	Anolis carolinensis	45.09	0.00e+00	817.00
IUUC-Bta-013080	Bos taurus	52.64	0.00e+00	993.00
IUUC-Cja-018891	Callithrix jacchus	53.56	0.00e+00	1030.00
IUUC-Cfa-020763	Canis familiaris	53.17	0.00e+00	910.00
IUUC-Cpo-022346	Cavia porcellus	51.79	0.00e+00	1016.00
IUUC-Csa-023049	Chlorocebus sabaeus	55.11	0.00e+00	1118.00
IUUC-Cho-025101	Choloepus hoffmanni	47.00	2.00e-128	453.00
IUUC-Dno-029093	Dasypus novemcinctus	54.27	0.00e+00	1069.00
IUUC-Dor-030862	Dipodomys ordii	38.25	0.00e+00	636.00
IUUC-Eca-034098	Equus caballus	54.81	0.00e+00	1014.00
IUUC-Eeu-035282	Erinaceus europaeus	41.99	4.00e-111	395.00
IUUC-Fca-036283	Felis catus	54.02	0.00e+00	1000.00
IUUC-Ggo-045553	Gorilla gorilla	53.81	0.00e+00	1079.00
IUUC-Hsa-046396	Homo sapiens	54.97	0.00e+00	1104.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	40.60	0.00e+00	716.00
IUUC-Loc-052700	Lepisosteus oculatus	38.38	0.00e+00	716.00
IUUC-Laf-054433	Loxodonta africana	51.96	0.00e+00	1082.00
IUUC-Mcc-055014	Macaca mulatta	52.25	0.00e+00	1056.00
IUUC-Mmr-060783	Microcebus murinus	39.54	0.00e+00	648.00
IUUC-Mdo-061839	Monodelphis domestica	64.55	0.00e+00	1230.00
IUUC-Mmu-064378	Mus musculus	49.37	0.00e+00	944.00
IUUC-Mpu-066293	Mustela putorius furo	51.69	0.00e+00	931.00
IUUC-Mlu-067407	Myotis lucifugus	52.13	0.00e+00	993.00
IUUC-Nle-069978	Nomascus leucogenys	54.53	0.00e+00	1111.00
IUUC-Opr-070190	Ochotona princeps	45.78	2.00e-147	516.00
IUUC-Ocu-074305	Oryctolagus cuniculus	45.64	0.00e+00	802.00
IUUC-Oga-088780	Otolemur garnettii	49.61	0.00e+00	939.00
IUUC-Oar-090307	Ovis aries	53.63	0.00e+00	1008.00
IUUC-Ptr-091567	Pan troglodytes	55.26	0.00e+00	1111.00
IUUC-Pan-091802	Papio anubis	50.91	0.00e+00	1007.00
IUUC-Pab-098024	Pongo abelii	45.85	0.00e+00	770.00
IUUC-Pca-100320	Procavia capensis	43.67	0.00e+00	781.00
IUUC-Pva-102382	Pteropus vampyrus	49.71	0.00e+00	931.00
IUUC-Rno-105768	Rattus norvegicus	48.45	0.00e+00	919.00
IUUC-Sar-113014	Sorex araneus	47.38	1.00e-116	413.00
IUUC-Tsy-119565	Tarsius syrichta	58.66	2.00e-123	436.00
IUUC-Tbe-127787	Tupaia belangeri	42.84	0.00e+00	705.00
IUUC-Ttr-128191	Tursiops truncatus	44.44	0.00e+00	805.00
IUUC-Vpa-130214	Vicugna pacos	50.99	0.00e+00	892.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence