iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004041

Ensembl Protein ID

ENSAPLP00000013414.1

UniProt Accession

R0L6V1; R0L6V1_ANAPL

Genbank Protein ID

EOA96002.1

Protein Name

E3 ubiquitin-protein ligase CBL

Genbank Nucleotide ID

ADON01121549

Gene Name

CBL; Anapl_12427

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000013545.1	ENSAPLT00000014166.1	ENSAPLP00000013414.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.30e-08	32.8	317	356
UBD/Alpha-Helix/UBA	6.00e-06	26.0	807	841

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    + +s  + CP Cr
   Q: 317  CKICAENDKD-VKIEPCGHLMCTSCLTAW----Q-ESEGQGCPFCR 356
           99********.******************....5.555555****8 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyL 38
           ++ +e+l+++G++ +++++aL+ a+nn+e+A + L
   Q: 807  SSEIENLMNQGYSYQDIQKALLIAHNNIEMAKNIL 841
           6779***************************9988 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

QVVRLCQNPK LALKNSPPYI LDLLPDTYQH LRTILSRYEG KMETLGENEY FRVFMENLMK 60
KTKQTISLFK EGKERMYEEN SQPRRNLTKL SLIFSHMLAE LKGIFPSGLF QGDTFRITKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTGGTGC GTTTGTGCCA GAACCCGAAG CTGGCGCTGA AGAACAGCCC GCCCTACATC 60
CTCGACCTGC TGCCTGACAC CTACCAGCAC CTCCGCACCA TCCTGTCGCG CTACGAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0016874--F:ligase activity
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	85.15	0.00e+00	1373.00
IUUC-Aca-004899	Anolis carolinensis	85.60	0.00e+00	1338.00
IUUC-Ame-010746	Astyanax mexicanus	61.65	0.00e+00	644.00
IUUC-Bta-012759	Bos taurus	84.85	0.00e+00	1377.00
IUUC-Cja-019207	Callithrix jacchus	83.92	0.00e+00	1360.00
IUUC-Cfa-020897	Canis familiaris	84.85	0.00e+00	1355.00
IUUC-Cpo-021453	Cavia porcellus	84.40	0.00e+00	1404.00
IUUC-Csa-023136	Chlorocebus sabaeus	84.13	0.00e+00	1355.00
IUUC-Cho-024282	Choloepus hoffmanni	75.87	0.00e+00	1096.00
IUUC-Csv-025938	Ciona savignyi	69.47	4.00e-167	580.00
IUUC-Dre-027644	Danio rerio	71.20	0.00e+00	1039.00
IUUC-Dno-030025	Dasypus novemcinctus	85.00	0.00e+00	1369.00
IUUC-Ete-033118	Echinops telfairi	69.48	0.00e+00	709.00
IUUC-Eca-033900	Equus caballus	86.36	0.00e+00	1395.00
IUUC-Eeu-035142	Erinaceus europaeus	81.44	0.00e+00	904.00
IUUC-Fca-035455	Felis catus	84.15	0.00e+00	1336.00
IUUC-Fal-037182	Ficedula albicollis	98.88	0.00e+00	890.00
IUUC-Gmo-038698	Gadus morhua	88.56	0.00e+00	842.00
IUUC-Gga-040438	Gallus gallus	96.84	0.00e+00	1551.00
IUUC-Gac-042166	Gasterosteus aculeatus	72.99	0.00e+00	858.00
IUUC-Ggo-045618	Gorilla gorilla	84.71	0.00e+00	1368.00
IUUC-Hsa-046177	Homo sapiens	84.13	0.00e+00	1357.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	90.35	0.00e+00	947.00
IUUC-Lch-050095	Latimeria chalumnae	76.27	0.00e+00	1159.00
IUUC-Loc-052570	Lepisosteus oculatus	73.13	0.00e+00	1105.00
IUUC-Laf-054008	Loxodonta africana	84.35	0.00e+00	1368.00
IUUC-Mcc-054676	Macaca mulatta	84.01	0.00e+00	1351.00
IUUC-Mga-059239	Meleagris gallopavo	96.73	0.00e+00	1583.00
IUUC-Mmr-060907	Microcebus murinus	82.65	0.00e+00	1337.00
IUUC-Mdo-062595	Monodelphis domestica	87.02	0.00e+00	1374.00
IUUC-Mmu-063725	Mus musculus	84.75	0.00e+00	1404.00
IUUC-Mpu-066771	Mustela putorius furo	84.44	0.00e+00	1360.00
IUUC-Mlu-067206	Myotis lucifugus	72.18	0.00e+00	1029.00
IUUC-Nle-069285	Nomascus leucogenys	82.07	0.00e+00	1275.00
IUUC-Opr-071026	Ochotona princeps	84.38	0.00e+00	1361.00
IUUC-Ont-071954	Oreochromis niloticus	70.78	0.00e+00	1035.00
IUUC-Ocu-074657	Oryctolagus cuniculus	85.73	0.00e+00	1365.00
IUUC-Ola-087165	Oryzias latipes	68.49	0.00e+00	1015.00
IUUC-Oga-088198	Otolemur garnettii	75.81	0.00e+00	1182.00
IUUC-Oar-090258	Ovis aries	84.95	0.00e+00	1360.00
IUUC-Ptr-090710	Pan troglodytes	84.13	0.00e+00	1357.00
IUUC-Pan-092785	Papio anubis	84.13	0.00e+00	1355.00
IUUC-Psi-093431	Pelodiscus sinensis	84.25	0.00e+00	780.00
IUUC-Pfo-096990	Poecilia formosa	90.50	0.00e+00	789.00
IUUC-Pab-098526	Pongo abelii	84.13	0.00e+00	1358.00
IUUC-Pva-102352	Pteropus vampyrus	97.09	0.00e+00	835.00
IUUC-Rno-105876	Rattus norvegicus	84.05	0.00e+00	1391.00
IUUC-Sha-107588	Sarcophilus harrisii	85.44	0.00e+00	1211.00
IUUC-Sar-112959	Sorex araneus	82.32	0.00e+00	1334.00
IUUC-Ssc-115261	Sus scrofa	85.06	0.00e+00	1373.00
IUUC-Tgu-116580	Taeniopygia guttata	91.24	0.00e+00	1425.00
IUUC-Tru-118731	Takifugu rubripes	68.87	0.00e+00	1026.00
IUUC-Tsy-118982	Tarsius syrichta	75.19	0.00e+00	896.00
IUUC-Tni-120725	Tetraodon nigroviridis	69.21	0.00e+00	1021.00
IUUC-Tbe-128018	Tupaia belangeri	91.52	0.00e+00	1105.00
IUUC-Ttr-128927	Tursiops truncatus	85.16	0.00e+00	1385.00
IUUC-Vpa-130369	Vicugna pacos	84.68	0.00e+00	1323.00
IUUC-Xtr-132474	Xenopus tropicalis	75.23	0.00e+00	1122.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence