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Tag Content
UUCD2 ID IUUC-Oga-088164
UUCD1 version UUC-OtG-00238
Ensembl Protein ID ENSOGAP00000004099.2
UniProt Accession H0WQ84; H0WQ84_OTOGA
Genbank Protein ID ENSOGAP00000004099
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID AAQR03081955
Gene Name WWP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOGAG00000004592.2 ENSOGAT00000004596.2 ENSOGAP00000004099.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.90e-136 454.3 537 869
Active Site
Position(s) Description Evidence
838 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 625  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 710
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 711  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDLSDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 799  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 869
           *********************************************************************96 PP
   
Organism Otolemur garnettii
Protein Sequence
(Fasta)
MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNILKNN GGKMENTQLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oga-088164|E3,HECT|Otolemur garnettii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCATCTG CCAGCTCCAG CCGGGCAGGA GTGGCCCTGC CTTTCGAGAA GTCTCAGCTT 60
ACTCTGAAAG GTGAGTGGCA CTGTGTGAGT TGTTTACCAT ATCTGTGGGG AAGAGGGTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oga-088164|E3,HECT|Otolemur garnettii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 96.10 0.00e+00 1649.00
IUUC-Apl-003912 Anas platyrhynchos 76.20 0.00e+00 1233.00
IUUC-Aca-004291 Anolis carolinensis 80.78 0.00e+00 1434.00
IUUC-Bta-013231 Bos taurus 95.98 0.00e+00 1615.00
IUUC-Cja-019455 Callithrix jacchus 96.32 0.00e+00 1692.00
IUUC-Cfa-021017 Canis familiaris 96.44 0.00e+00 1635.00
IUUC-Cpo-021988 Cavia porcellus 96.55 0.00e+00 1687.00
IUUC-Csa-023549 Chlorocebus sabaeus 96.67 0.00e+00 1703.00
IUUC-Dre-028513 Danio rerio 91.77 0.00e+00 1134.00
IUUC-Dno-028976 Dasypus novemcinctus 96.56 0.00e+00 1684.00
IUUC-Dor-030176 Dipodomys ordii 93.38 0.00e+00 1514.00
IUUC-Eca-033949 Equus caballus 96.67 0.00e+00 1657.00
IUUC-Eeu-034529 Erinaceus europaeus 89.12 0.00e+00 1387.00
IUUC-Fca-036236 Felis catus 96.44 0.00e+00 1688.00
IUUC-Fal-036948 Ficedula albicollis 78.66 0.00e+00 1335.00
IUUC-Gmo-038842 Gadus morhua 89.24 0.00e+00 1071.00
IUUC-Gga-040617 Gallus gallus 80.24 0.00e+00 1438.00
IUUC-Gac-041338 Gasterosteus aculeatus 69.66 0.00e+00 1250.00
IUUC-Ggo-045278 Gorilla gorilla 96.90 0.00e+00 1707.00
IUUC-Hsa-046148 Homo sapiens 96.90 0.00e+00 1708.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 98.32 0.00e+00 1121.00
IUUC-Lch-050663 Latimeria chalumnae 78.82 0.00e+00 1396.00
IUUC-Loc-052604 Lepisosteus oculatus 76.36 0.00e+00 1321.00
IUUC-Laf-053944 Loxodonta africana 96.55 0.00e+00 1680.00
IUUC-Mcc-055655 Macaca mulatta 96.55 0.00e+00 1705.00
IUUC-Meu-055953 Macropus eugenii 80.39 0.00e+00 1390.00
IUUC-Mga-060190 Meleagris gallopavo 80.95 0.00e+00 1439.00
IUUC-Mmr-060896 Microcebus murinus 97.80 0.00e+00 1659.00
IUUC-Mdo-062536 Monodelphis domestica 91.28 0.00e+00 1613.00
IUUC-Mmu-064017 Mus musculus 96.09 0.00e+00 1662.00
IUUC-Mpu-066608 Mustela putorius furo 94.27 0.00e+00 1597.00
IUUC-Mlu-067623 Myotis lucifugus 93.23 0.00e+00 1603.00
IUUC-Nle-069496 Nomascus leucogenys 94.72 0.00e+00 1654.00
IUUC-Opr-071054 Ochotona princeps 85.04 0.00e+00 1442.00
IUUC-Ont-071279 Oreochromis niloticus 73.75 0.00e+00 1279.00
IUUC-Oan-073512 Ornithorhynchus anatinus 88.30 0.00e+00 1498.00
IUUC-Ocu-074271 Oryctolagus cuniculus 96.27 0.00e+00 1639.00
IUUC-Ola-087237 Oryzias latipes 69.54 0.00e+00 1227.00
IUUC-Oar-089698 Ovis aries 96.09 0.00e+00 1623.00
IUUC-Ptr-091306 Pan troglodytes 95.63 0.00e+00 1676.00
IUUC-Pan-092814 Papio anubis 92.89 0.00e+00 1610.00
IUUC-Pfo-096709 Poecilia formosa 73.75 0.00e+00 1278.00
IUUC-Pab-098494 Pongo abelii 90.96 0.00e+00 1606.00
IUUC-Pca-100596 Procavia capensis 84.16 0.00e+00 1392.00
IUUC-Pva-103154 Pteropus vampyrus 91.32 0.00e+00 1566.00
IUUC-Rno-104954 Rattus norvegicus 95.38 0.00e+00 1415.00
IUUC-Sha-106781 Sarcophilus harrisii 91.51 0.00e+00 1659.00
IUUC-Sre-114929 Sporisorium reilianum 46.26 5.00e-151 528.00
IUUC-Ssc-116307 Sus scrofa 84.96 0.00e+00 1453.00
IUUC-Tgu-116530 Taeniopygia guttata 76.35 0.00e+00 1192.00
IUUC-Tru-118287 Takifugu rubripes 89.46 0.00e+00 1065.00
IUUC-Tsy-119097 Tarsius syrichta 84.25 0.00e+00 1243.00
IUUC-Tni-120801 Tetraodon nigroviridis 67.59 0.00e+00 1137.00
IUUC-Tbe-127793 Tupaia belangeri 85.29 0.00e+00 1453.00
IUUC-Ttr-128275 Tursiops truncatus 91.61 0.00e+00 1553.00
IUUC-Uma-129332 Ustilago maydis 46.70 2.00e-143 503.00
IUUC-Xtr-132866 Xenopus tropicalis 82.64 0.00e+00 1137.00
Created Date 25-Jun-2017

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