iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-061890

UUCD1 version

UUC-MoD-01152

Ensembl Protein ID

ENSMODP00000023032.3

UniProt Accession

F7CAJ0; F7CAJ0_MONDO

Protein Name

Uncharacterized protein

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000018469.3	ENSMODT00000023442.3	ENSMODP00000023032.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.50e-57	193.0	22	334

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl N+g t  +NS+LQ+ ++ +++++ l++   +++l+e+     k ++ ++l  l+e++++s+ +av p el  +lk++++    + 
   Q: 22   VGLYNIGQTSCLNSLLQVFIMNQNFTKILKRiTMPRELEER-----KRSVPCQLLLLLEKMQDSRLRAVWPVELAFCLKTCNVP--LFV 103
           6******************************7777777655.....67**********************************98..79* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp 177
           q+Da  ++  l + +++++                          ++   ++ +++l+ ++++++++cl+c+++  r++++l lsl++ 
   Q: 104  QHDAAQLFLTLWNLIQSQI--------------------------TDLDLSERLKTLYTVTVRESLVCLDCNSKRHRDSKMLILSLSLF 166
           *******************..........................67788999************************************ PP
   S: 178  gkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
           + +++ +++l+d+L+ f+++++l g+nk++ e+c k +  +++ kl +lP++L++hL+Rfs +   ++ +ki   ++fp++Ld+s+++ 
   Q: 167  DTDSKPLQTLEDSLHYFFQPKMLSGKNKCFYENCGKMTCWQQTQKLMHLPPMLTFHLMRFSSKDF-SKTQKIIHPLSFPQHLDISQVLP 254
           ************************************************************76555.7778****************777 PP
   S: 267  spee.kqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkr 337
           ++++  ++e ++YeL+avv H+G+++ GHY+ay+ n  +g+W++f+Ds+V  v++e+++++ g       +taY+lfYk+
   Q: 255  EEQDwWDSEGQQYELFAVVAHMGTANFGHYCAYICNpADGQWFCFNDSSVCWVTWEDIKRTYGnynlcwgETAYLLFYKK 334
           6554146679************************9956777*******************888***************98 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MKRKTRQLRY LYNAGDCYTG PVGLYNIGQT SCLNSLLQVF IMNQNFTKIL KRITMPRELE 60
ERKRSVPCQL LLLLEKMQDS RLRAVWPVEL AFCLKTCNVP LFVQHDAAQL FLTLWNLIQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCGGAAGCA TGTGGACCAT CATTTCTTTT CTCAAAACTT TGATGTATAC ATGATAAGCA 60
CACACCAAAA ATAACTGTGC GCACAATAAA CATCAAACGG TCAAATCAGA AGTGCCTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mdo:100022228

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	66.56	3.00e-122	431.00
IUUC-Apl-004006	Anas platyrhynchos	54.23	5.00e-94	337.00
IUUC-Aca-005088	Anolis carolinensis	49.40	4.00e-82	298.00
IUUC-Ame-010606	Astyanax mexicanus	30.36	7.00e-37	147.00
IUUC-Bta-013036	Bos taurus	60.44	1.00e-114	405.00
IUUC-Cja-019052	Callithrix jacchus	60.06	5.00e-109	387.00
IUUC-Cfa-020554	Canis familiaris	66.18	5.00e-130	457.00
IUUC-Cpo-022421	Cavia porcellus	62.68	3.00e-117	415.00
IUUC-Csa-023737	Chlorocebus sabaeus	60.59	1.00e-67	248.00
IUUC-Cho-024807	Choloepus hoffmanni	54.87	5.00e-50	191.00
IUUC-Dre-027408	Danio rerio	32.09	3.00e-37	148.00
IUUC-Dno-029813	Dasypus novemcinctus	54.17	6.00e-87	313.00
IUUC-Dor-030532	Dipodomys ordii	61.95	3.00e-116	411.00
IUUC-Ete-032254	Echinops telfairi	62.08	1.00e-116	412.00
IUUC-Eca-033482	Equus caballus	66.36	8.00e-122	429.00
IUUC-Eeu-034451	Erinaceus europaeus	58.49	6.00e-69	253.00
IUUC-Fca-036313	Felis catus	65.85	8.00e-127	446.00
IUUC-Fal-037216	Ficedula albicollis	50.87	6.00e-94	337.00
IUUC-Gmo-038649	Gadus morhua	31.88	4.00e-39	155.00
IUUC-Gga-041082	Gallus gallus	53.19	2.00e-88	318.00
IUUC-Gac-042439	Gasterosteus aculeatus	35.22	7.00e-42	164.00
IUUC-Ggo-044957	Gorilla gorilla	62.50	3.00e-97	347.00
IUUC-Hsa-046381	Homo sapiens	63.39	1.00e-121	429.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	63.24	1.00e-118	419.00
IUUC-Loc-052688	Lepisosteus oculatus	34.04	1.00e-44	173.00
IUUC-Laf-054109	Loxodonta africana	64.12	1.00e-123	436.00
IUUC-Mcc-054814	Macaca mulatta	63.13	1.00e-121	429.00
IUUC-Meu-056253	Macropus eugenii	79.79	4.00e-126	443.00
IUUC-Mmr-061613	Microcebus murinus	64.09	8.00e-123	433.00
IUUC-Mmu-064329	Mus musculus	62.72	6.00e-114	404.00
IUUC-Mpu-066342	Mustela putorius furo	65.87	1.00e-125	442.00
IUUC-Mlu-067010	Myotis lucifugus	62.72	1.00e-122	432.00
IUUC-Nle-069148	Nomascus leucogenys	62.80	3.00e-118	418.00
IUUC-Opr-070988	Ochotona princeps	59.87	2.00e-51	196.00
IUUC-Ont-072039	Oreochromis niloticus	34.18	2.00e-41	162.00
IUUC-Oan-073740	Ornithorhynchus anatinus	55.71	6.00e-71	260.00
IUUC-Ocu-074498	Oryctolagus cuniculus	66.25	3.00e-114	404.00
IUUC-Ola-086753	Oryzias latipes	35.67	2.00e-45	176.00
IUUC-Oga-088497	Otolemur garnettii	65.03	4.00e-120	424.00
IUUC-Oar-089505	Ovis aries	60.44	2.00e-114	405.00
IUUC-Ptr-091656	Pan troglodytes	62.80	2.00e-119	422.00
IUUC-Pan-092498	Papio anubis	63.13	9.00e-122	429.00
IUUC-Psi-093409	Pelodiscus sinensis	52.60	3.00e-96	345.00
IUUC-Pfo-096507	Poecilia formosa	31.75	3.00e-36	145.00
IUUC-Pab-097828	Pongo abelii	63.16	5.00e-116	410.00
IUUC-Pca-100299	Procavia capensis	65.53	2.00e-74	272.00
IUUC-Pva-102972	Pteropus vampyrus	63.47	3.00e-120	424.00
IUUC-Rno-105738	Rattus norvegicus	61.49	2.00e-114	405.00
IUUC-Sha-107309	Sarcophilus harrisii	80.06	6.00e-153	533.00
IUUC-Sar-112983	Sorex araneus	60.07	1.00e-91	329.00
IUUC-Ssc-116049	Sus scrofa	63.55	9.00e-122	429.00
IUUC-Tgu-117115	Taeniopygia guttata	53.29	1.00e-94	339.00
IUUC-Tru-118022	Takifugu rubripes	31.03	5.00e-34	138.00
IUUC-Tsy-118986	Tarsius syrichta	69.35	5.00e-47	181.00
IUUC-Tni-120306	Tetraodon nigroviridis	31.31	1.00e-35	143.00
IUUC-Tbe-127768	Tupaia belangeri	55.09	3.00e-72	265.00
IUUC-Ttr-128686	Tursiops truncatus	61.80	5.00e-115	407.00
IUUC-Xtr-132032	Xenopus tropicalis	41.01	8.00e-63	233.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence