iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089505

Ensembl Protein ID

ENSOARP00000020702.1

UniProt Accession

W5QDA4; W5QDA4_SHEEP

Genbank Protein ID

ENSOARP00000020702

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01082306

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000019272.1	ENSOART00000020987.1	ENSOARP00000020702.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-58	198.9	4	318

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+N+g tC +NS++Q+L+    +++ l++   +  +     +e+ +++  +l  l+e++++s+kkav+p+el  +l+k++     + 
   Q: 4    VGLHNIGQTCCLNSLIQVLVRNVGFAKILKRiTVPGGV-----EEQRKSVPFQLLLLLEKMQDSRKKAVQPTELAYCLQKYNIP--LFV 85
           6******************************4444444.....466789*********************************77..89* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp 177
           q+Da  +   + + +++++                          ++      ++ l+ ++lk+++ clec ++  r++++l l+l+v 
   Q: 86   QHDAAQLYLTVWNLIKDQI--------------------------TDVDLVARLQALYTIRLKESLACLECTSEMGRNSSMLALPLSVF 148
           *******************..........................567788999*********************************** PP
   S: 178  gkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
           + + + +++l+d+L+ f++++el + +k++c +c +k++ ++ l+l++lP++L++hL+Rfs   ++ + ek+  +++fp++Ldl++ ++
   Q: 149  DMHWKPLKTLEDALHCFFQPQELSSTDKCFCGSCGRKTRWRQVLTLTHLPQTLTIHLMRFSI--RNLRAEKVCHSLYFPQSLDLTKLLE 235
           ************************************************************66..568999***************9888 PP
   S: 267  s.....peekqke....kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.......staYvlfYkr 337
           +     +             YeL+av+ H G+++ GHY+ay+++++++ W++f+Ds+V  v++++v+ + g       +taY+lfY +
   Q: 236  TegepcS-----AeeqhGGHYELFAVIAHVGNADYGHYCAYIRSSEDGeWFCFNDSNVCWVSWKDVQCTYGnhnyrwrETAYLLFYVK 318
           7444321.....2333489************************965555*******************888***************76 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MGPVGLHNIG QTCCLNSLIQ VLVRNVGFAK ILKRITVPGG VEEQRKSVPF QLLLLLEKMQ 60
DSRKKAVQPT ELAYCLQKYN IPLFVQHDAA QLYLTVWNLI KDQITDVDLV ARLQALYTIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGCCTCCC AAGGCCAGCT CATGAGAGCT CTTCTGGGAA GTGAGGTCAA GCTGTCCTGA 60
AGACGCCTGC AGCAGCTGTC AGTCCAGGGA CCTTGGAGCA ACCACTGATG GGTACGTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

oas:101103965

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	79.41	2.00e-147	514.00
IUUC-Apl-004006	Anas platyrhynchos	54.72	2.00e-99	355.00
IUUC-Aca-005088	Anolis carolinensis	51.26	7.00e-84	303.00
IUUC-Ame-010606	Astyanax mexicanus	33.12	1.00e-40	159.00
IUUC-Bta-013036	Bos taurus	94.69	0.00e+00	637.00
IUUC-Cja-019052	Callithrix jacchus	69.88	5.00e-132	463.00
IUUC-Cfa-020554	Canis familiaris	79.38	9.00e-155	539.00
IUUC-Cpo-022421	Cavia porcellus	71.83	4.00e-136	477.00
IUUC-Csa-023737	Chlorocebus sabaeus	71.29	2.00e-88	317.00
IUUC-Cho-024807	Choloepus hoffmanni	63.45	6.00e-65	241.00
IUUC-Dre-027408	Danio rerio	33.44	5.00e-45	174.00
IUUC-Dno-029813	Dasypus novemcinctus	65.00	1.00e-110	392.00
IUUC-Dor-030532	Dipodomys ordii	71.70	6.00e-136	476.00
IUUC-Ete-032254	Echinops telfairi	68.44	4.00e-134	471.00
IUUC-Eca-033482	Equus caballus	78.82	4.00e-153	533.00
IUUC-Eeu-034451	Erinaceus europaeus	70.75	1.00e-90	325.00
IUUC-Fca-036313	Felis catus	80.00	5.00e-157	546.00
IUUC-Fal-037216	Ficedula albicollis	56.60	7.00e-100	357.00
IUUC-Gmo-038649	Gadus morhua	33.33	2.00e-40	159.00
IUUC-Gga-041082	Gallus gallus	53.14	3.00e-90	325.00
IUUC-Gac-042439	Gasterosteus aculeatus	36.28	3.00e-49	188.00
IUUC-Ggo-044957	Gorilla gorilla	75.00	3.00e-125	441.00
IUUC-Hsa-046381	Homo sapiens	75.86	4.00e-148	517.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	74.69	4.00e-142	497.00
IUUC-Loc-052688	Lepisosteus oculatus	32.72	1.00e-44	173.00
IUUC-Laf-054109	Loxodonta africana	73.75	6.00e-144	503.00
IUUC-Mcc-054814	Macaca mulatta	75.24	3.00e-148	518.00
IUUC-Meu-056253	Macropus eugenii	62.15	2.00e-101	361.00
IUUC-Mmr-061613	Microcebus murinus	74.06	8.00e-143	499.00
IUUC-Mdo-061890	Monodelphis domestica	60.44	2.00e-114	405.00
IUUC-Mmu-064329	Mus musculus	71.56	2.00e-132	464.00
IUUC-Mpu-066342	Mustela putorius furo	80.00	5.00e-155	540.00
IUUC-Mlu-067010	Myotis lucifugus	78.75	1.00e-153	535.00
IUUC-Nle-069148	Nomascus leucogenys	75.24	4.00e-147	514.00
IUUC-Opr-070988	Ochotona princeps	64.74	5.00e-59	221.00
IUUC-Ont-072039	Oreochromis niloticus	34.28	6.00e-46	177.00
IUUC-Oan-073740	Ornithorhynchus anatinus	51.97	5.00e-68	250.00
IUUC-Ocu-074498	Oryctolagus cuniculus	74.61	4.00e-136	477.00
IUUC-Ola-086753	Oryzias latipes	36.59	3.00e-50	192.00
IUUC-Oga-088497	Otolemur garnettii	75.16	1.00e-139	489.00
IUUC-Ptr-091656	Pan troglodytes	75.24	4.00e-147	514.00
IUUC-Pan-092498	Papio anubis	75.55	7.00e-149	520.00
IUUC-Psi-093409	Pelodiscus sinensis	53.52	2.00e-96	345.00
IUUC-Pfo-096507	Poecilia formosa	36.91	7.00e-50	191.00
IUUC-Pab-097828	Pongo abelii	74.53	6.00e-146	509.00
IUUC-Pca-100299	Procavia capensis	74.07	8.00e-81	293.00
IUUC-Pva-102972	Pteropus vampyrus	76.88	3.00e-148	518.00
IUUC-Rno-105738	Rattus norvegicus	69.69	2.00e-133	468.00
IUUC-Sha-107309	Sarcophilus harrisii	61.06	8.00e-108	383.00
IUUC-Sar-112983	Sorex araneus	71.08	2.00e-117	415.00
IUUC-Ssc-116049	Sus scrofa	81.93	4.00e-162	563.00
IUUC-Tgu-117115	Taeniopygia guttata	55.66	4.00e-99	354.00
IUUC-Tru-118022	Takifugu rubripes	33.33	2.00e-39	156.00
IUUC-Tsy-118986	Tarsius syrichta	77.42	4.00e-53	201.00
IUUC-Tni-120306	Tetraodon nigroviridis	33.44	8.00e-39	154.00
IUUC-Tbe-127768	Tupaia belangeri	67.76	2.00e-91	328.00
IUUC-Ttr-128686	Tursiops truncatus	80.31	4.00e-156	543.00
IUUC-Xtr-132032	Xenopus tropicalis	42.50	1.00e-67	249.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence