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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018188
UUCD1 version UUC-CaE-00054
Ensembl Protein ID C12C8.3b.1
UniProt Accession Q9U489; Q9U490; LIN41_CAEEL
Genbank Protein ID AAF15529.1; AAF15530.1; CAC42255.1; CAC42254.1
Protein Name Protein lin-41; Abnormal cell lineage protein 41
Genbank Nucleotide ID AF195610; AF195611; Z81467; Z81467
Gene Name lin-41; C12C8.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003026 C12C8.3a.1 C12C8.3a.1
WBGene00003026 C12C8.3b.1 C12C8.3b.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
miRTarBaseTRANSFACmiRecordsRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDB
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18636104
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 35.95 5.00e-106 384.00 IUUC-Hsa-045988
E3 activity/RING/RING 35.06 2.00e-104 378.00 IUUC-Mmu-064351
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Heterochronic protein which acts downstream let-7 in temporal patterning. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Also governs the timing and extent of male tail tip morphogenesis.
 Heterochronic protein which acts downstream let-7 in temporal patterning. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Also governs the timing and extent of male tail tip morphogenesis.
Protein Sequence
(Fasta)
MATIVPCSLE KEEGAPSGPR RLQTEIDVDA NDSGNELSMG GSSSEGDSMS HHRGEHSPNH 60
HHQDNHLGSG PPPPQFTGSL FDTPPSMIQS PQQQPQFQFN TGFGLGLPQD SFRCSVCSKS 120
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Protein Fasta Sequence


>IUUC-Cel-018188|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCACGGTTG GCGAACGGGT AAAAAGGAAG AGCCGATCGC CTCGTTACTC AAGGAAAAGG 60
CTCGACGTCG CTGGAGGAGG GAAAAGTTGG TTTTTTAGGA TAAAAACCAA CTTAAAGTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018188|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR015943--WD40/YVTN_repeat-like_dom
IPR000315--Znf_B-box
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
Pfam

PF00630--Filamin
PF01436--NHL
SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
Gene Ontology

GO:0005737--C:cytoplasm
GO:1990124--C:messenger ribonucleoprotein complex
GO:0030371--F:translation repressor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0009957--P:epidermal cell fate specification
GO:0007276--P:gamete generation
GO:0044268--P:multicellular organismal protein metabolic process
GO:0045138--P:nematode male tail tip morphogenesis
GO:0010628--P:positive regulation of gene expression
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0040034--P:regulation of development, heterochronic
GO:0045604--P:regulation of epidermal cell differentiation
KEGG cel:CELE_C12C8.3
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001234 Ailuropoda melanoleuca 36.32 2.00e-114 404.00
IUUC-Apl-003905 Anas platyrhynchos 36.35 9.00e-109 386.00
IUUC-Aca-004326 Anolis carolinensis 35.10 4.00e-109 387.00
IUUC-Ame-011573 Astyanax mexicanus 36.18 2.00e-122 431.00
IUUC-Bta-013395 Bos taurus 35.68 2.00e-112 399.00
IUUC-Cja-019863 Callithrix jacchus 35.83 3.00e-113 401.00
IUUC-Cfa-020285 Canis familiaris 33.72 1.00e-114 406.00
IUUC-Cpo-021879 Cavia porcellus 33.97 9.00e-118 416.00
IUUC-Csa-024271 Chlorocebus sabaeus 35.83 9.00e-113 400.00
IUUC-Cho-024376 Choloepus hoffmanni 35.58 2.00e-109 388.00
IUUC-Cin-025406 Ciona intestinalis 34.06 7.00e-110 390.00
IUUC-Dre-027699 Danio rerio 35.90 1.00e-122 432.00
IUUC-Dno-029022 Dasypus novemcinctus 36.02 3.00e-113 400.00
IUUC-Dor-031072 Dipodomys ordii 35.83 2.00e-112 398.00
IUUC-Dme-031997 Drosophila melanogaster 41.41 4.00e-70 258.00
IUUC-Ete-032228 Echinops telfairi 45.99 4.00e-95 340.00
IUUC-Eca-033373 Equus caballus 38.10 1.00e-109 389.00
IUUC-Eeu-034463 Erinaceus europaeus 36.29 8.00e-111 392.00
IUUC-Fca-036184 Felis catus 36.10 3.00e-112 397.00
IUUC-Fal-036918 Ficedula albicollis 36.07 1.00e-110 392.00
IUUC-Gmo-039415 Gadus morhua 32.49 2.00e-82 299.00
IUUC-Gga-040379 Gallus gallus 33.72 3.00e-114 405.00
IUUC-Gac-042330 Gasterosteus aculeatus 32.52 2.00e-96 345.00
IUUC-Ggo-045208 Gorilla gorilla 35.98 5.00e-112 397.00
IUUC-Hsa-045988 Homo sapiens 35.83 1.00e-112 399.00
IUUC-Itr-048371 Ictidomys tridecemlineatus 35.72 5.00e-111 393.00
IUUC-Lch-050324 Latimeria chalumnae 35.41 4.00e-112 397.00
IUUC-Loc-052322 Lepisosteus oculatus 36.54 1.00e-123 436.00
IUUC-Laf-054272 Loxodonta africana 35.54 2.00e-109 388.00
IUUC-Mcc-055125 Macaca mulatta 35.83 6.00e-113 400.00
IUUC-Meu-055934 Macropus eugenii 38.21 5.00e-109 387.00
IUUC-Mga-059930 Meleagris gallopavo 35.65 5.00e-107 380.00
IUUC-Mmr-060662 Microcebus murinus 33.76 7.00e-114 403.00
IUUC-Mdo-062918 Monodelphis domestica 35.68 4.00e-111 394.00
IUUC-Mmu-064351 Mus musculus 34.95 1.00e-110 393.00
IUUC-Mpu-066325 Mustela putorius furo 38.10 2.00e-109 388.00
IUUC-Mlu-067171 Myotis lucifugus 35.83 2.00e-113 402.00
IUUC-Nle-069692 Nomascus leucogenys 35.83 3.00e-112 398.00
IUUC-Opr-070354 Ochotona princeps 35.97 2.00e-110 392.00
IUUC-Ont-072125 Oreochromis niloticus 36.72 4.00e-122 431.00
IUUC-Oan-073079 Ornithorhynchus anatinus 35.87 3.00e-110 390.00
IUUC-Ocu-073910 Oryctolagus cuniculus 34.35 3.00e-118 417.00
IUUC-Ola-087162 Oryzias latipes 36.32 2.00e-120 425.00
IUUC-Oga-088523 Otolemur garnettii 36.14 8.00e-114 403.00
IUUC-Oar-089931 Ovis aries 24.65 9.00e-48 184.00
IUUC-Ptr-091173 Pan troglodytes 35.83 1.00e-112 399.00
IUUC-Pan-091750 Papio anubis 35.78 7.00e-112 397.00
IUUC-Psi-093053 Pelodiscus sinensis 35.05 5.00e-103 367.00
IUUC-Pma-094227 Petromyzon marinus 34.98 2.00e-95 341.00
IUUC-Pfo-096980 Poecilia formosa 34.90 9.00e-118 416.00
IUUC-Pab-098189 Pongo abelii 33.72 5.00e-115 407.00
IUUC-Pva-103126 Pteropus vampyrus 35.83 1.00e-111 396.00
IUUC-Rno-105653 Rattus norvegicus 35.41 2.00e-112 399.00
IUUC-Sce-106450 Saccharomyces cerevisiae 27.18 1.70e-02 34.70
IUUC-Sha-107178 Sarcophilus harrisii 36.47 6.00e-111 393.00
IUUC-Sar-113613 Sorex araneus 40.77 6.00e-99 353.00
IUUC-Ssc-115253 Sus scrofa 25.28 1.00e-47 183.00
IUUC-Tgu-116963 Taeniopygia guttata 35.50 6.00e-108 383.00
IUUC-Tru-117942 Takifugu rubripes 36.06 4.00e-120 424.00
IUUC-Tsy-119075 Tarsius syrichta 37.30 3.00e-96 344.00
IUUC-Tni-120704 Tetraodon nigroviridis 37.67 2.00e-112 398.00
IUUC-Tbe-128141 Tupaia belangeri 49.21 4.00e-83 300.00
IUUC-Ttr-128897 Tursiops truncatus 24.44 4.00e-45 174.00
IUUC-Xtr-132272 Xenopus tropicalis 36.50 8.00e-114 403.00
Created Date 25-Jun-2017

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