iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.80e-94	316.4	124	758

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp.........kepkgellkslqklfeelwkskkkavspr 71
           Gl+N+gNtC+mN++LQcLsn++ ++e+l            +         p         ++ +ge++++l++l+++lw+ + +    r
   Q: 124  GLRNHGNTCFMNATLQCLSNTELFAEYLALgqyragrpepE---------PeseqpagrgPHGQGEVTEQLAHLVRALWTLEYTPQHSR 203
           9***************************9965555544432.........122223333356667************************ PP
   S: 72   ellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecd 160
           +++++++k a +++g++q+DaqEfl +lld+++e+l++    +++ +   +  + +d+ +e +    ++++++lFq q++s+++c++c+
   Q: 204  DFKSIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNH--AVKQSGQPPLKPPSETDMMPEGPFPVCSTFVQELFQAQYRSSLTCPHCQ 290
           ************************************54..4444444444555667788999999999********************* PP
   S: 161  nvssreepfldlslpvpgkeetkke................................................................ 185
           ++s++++pfl +slp+p  +++ ++                                                                
   Q: 291  KQSNTFDPFLCISLPIPLPHTR-PLyvtvvyqgkcshcmrigvavplsgtvarlreavsmetkiptdqivltemyydgfhrsfsdtddl 378
           *****************87755.34689************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 379  etvhesdcifafetpeifrpegilsqrgihlnnnlnhlkfgldhhrlsspaptaakqgrvdlptrvasdkivllvcnractgqqgkrfg 467
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 468  lpfvlhlektvawdllqkeilekmkyflrptvsiqvcpfslrvvsvvgityllpqeeqplchptveralkscgpggtahvklvvewdke 556
           ***************************************************************************************** PP
   S: 186  .................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
                                            +l++c++ +tkee+l  ++++ c++ck++q+ + +l+l++lP+vLi+hLkRf  ++
   Q: 557  tkdflfvntedeyipdaesvrlqkeqhhqpqtcTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRF--RQ 643
           *************************************************************************************..99 PP
   S: 242  eqksrekinkkvefple.Ldlspfctspeekqke...................kkkYeLiavvvHsGslssGHYvayvknekgk.Wllf 309
           e+++r k+++ v+fpl+ Ld++p+++++++++ +                   +++Y+L+av++H+G++++GHY+ay+kn+ ++ W++f
   Q: 644  EGDRRMKLQNMVKFPLTgLDMTPHVVKRSQSSWSlpshwspwrrpyglgrdpeDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGlWYCF 732
           **************************977666559999999999999999999***************************87777**** PP
   S: 310  dDskVtevkeeevleetgstaYvlfYkrr 338
           dDs V++++e+ev++   +taY+lfY+rr
   Q: 733  DDSDVQQLSEDEVCT---QTAYILFYQRR 758
           ***************...*********96 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MSKVTAPGPG PPVAAGGKEK RSFSKRLFRS GRAGGGGGAG GPGPAAPSSP SSARSVGSFM 60
SRVLKTLSTL SHLSSEGAAP DRGGLRSCFP PGPASAPTPP PCPPPPASPA PPACASEPVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAAGG TAACGGCGCC CGGGCCCGGG CCGCCGGTGG CGGCGGGCGG GAAGGAGAAG 60
CGCTCGTTCA GCAAGCGGCT GTTCCGGAGT GGCCGCGCGG GGGGCGGCGG CGGCGCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:76179

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001207	Ailuropoda melanoleuca	89.04	0.00e+00	1840.00
IUUC-Apl-003186	Anas platyrhynchos	75.37	0.00e+00	1400.00
IUUC-Aca-004949	Anolis carolinensis	68.33	0.00e+00	1406.00
IUUC-Ame-010968	Astyanax mexicanus	66.70	0.00e+00	1085.00
IUUC-Bta-013271	Bos taurus	88.36	0.00e+00	1785.00
IUUC-Cja-019663	Callithrix jacchus	90.21	0.00e+00	1655.00
IUUC-Cfa-021258	Canis familiaris	89.09	0.00e+00	1840.00
IUUC-Csa-024188	Chlorocebus sabaeus	94.98	0.00e+00	1555.00
IUUC-Cho-024813	Choloepus hoffmanni	83.77	0.00e+00	1500.00
IUUC-Csv-026086	Ciona savignyi	38.72	3.00e-134	472.00
IUUC-Dre-027372	Danio rerio	70.52	0.00e+00	1006.00
IUUC-Dno-029964	Dasypus novemcinctus	85.25	0.00e+00	1704.00
IUUC-Dor-030448	Dipodomys ordii	81.46	0.00e+00	1108.00
IUUC-Ete-032975	Echinops telfairi	73.56	0.00e+00	1365.00
IUUC-Eca-034030	Equus caballus	89.98	0.00e+00	1797.00
IUUC-Eeu-034629	Erinaceus europaeus	73.43	0.00e+00	1116.00
IUUC-Fca-035788	Felis catus	93.78	0.00e+00	1522.00
IUUC-Fal-036874	Ficedula albicollis	82.35	0.00e+00	1243.00
IUUC-Gmo-039479	Gadus morhua	65.93	0.00e+00	1145.00
IUUC-Gga-041092	Gallus gallus	76.81	0.00e+00	1411.00
IUUC-Gac-041609	Gasterosteus aculeatus	71.06	0.00e+00	1125.00
IUUC-Ggo-044782	Gorilla gorilla	89.24	0.00e+00	707.00
IUUC-Hsa-046805	Homo sapiens	89.59	0.00e+00	1863.00
IUUC-Itr-048158	Ictidomys tridecemlineatus	90.98	0.00e+00	1681.00
IUUC-Lch-050332	Latimeria chalumnae	64.09	0.00e+00	1269.00
IUUC-Loc-051953	Lepisosteus oculatus	60.59	0.00e+00	1242.00
IUUC-Mcc-055398	Macaca mulatta	91.33	0.00e+00	1888.00
IUUC-Meu-056822	Macropus eugenii	77.40	0.00e+00	1427.00
IUUC-Mga-060115	Meleagris gallopavo	81.24	0.00e+00	1252.00
IUUC-Mmr-061150	Microcebus murinus	94.37	0.00e+00	1567.00
IUUC-Mdo-062700	Monodelphis domestica	79.25	0.00e+00	1756.00
IUUC-Mpu-066059	Mustela putorius furo	84.99	0.00e+00	1604.00
IUUC-Mlu-067870	Myotis lucifugus	84.21	0.00e+00	1635.00
IUUC-Nle-069898	Nomascus leucogenys	90.95	0.00e+00	1807.00
IUUC-Opr-070338	Ochotona princeps	79.96	0.00e+00	848.00
IUUC-Ont-072469	Oreochromis niloticus	68.66	0.00e+00	1103.00
IUUC-Oan-073175	Ornithorhynchus anatinus	84.18	0.00e+00	1305.00
IUUC-Ola-087303	Oryzias latipes	69.38	0.00e+00	1084.00
IUUC-Oga-089021	Otolemur garnettii	94.26	0.00e+00	1560.00
IUUC-Oar-090016	Ovis aries	88.86	0.00e+00	1749.00
IUUC-Ptr-090864	Pan troglodytes	89.88	0.00e+00	1870.00
IUUC-Pan-092370	Papio anubis	94.84	0.00e+00	1566.00
IUUC-Psi-093881	Pelodiscus sinensis	74.11	0.00e+00	1404.00
IUUC-Pfo-097427	Poecilia formosa	69.85	0.00e+00	1112.00
IUUC-Pab-098104	Pongo abelii	86.37	0.00e+00	1803.00
IUUC-Pca-100640	Procavia capensis	95.00	5.00e-119	422.00
IUUC-Pva-102287	Pteropus vampyrus	79.42	0.00e+00	1440.00
IUUC-Rno-106033	Rattus norvegicus	97.69	0.00e+00	1912.00
IUUC-Sha-107041	Sarcophilus harrisii	83.57	0.00e+00	1607.00
IUUC-Ssc-116412	Sus scrofa	90.77	2.00e-155	542.00
IUUC-Tgu-116889	Taeniopygia guttata	74.87	0.00e+00	1399.00
IUUC-Tru-118340	Takifugu rubripes	70.24	0.00e+00	1108.00
IUUC-Tsy-118887	Tarsius syrichta	84.05	0.00e+00	1612.00
IUUC-Tni-120463	Tetraodon nigroviridis	70.10	0.00e+00	1107.00
IUUC-Tbe-127491	Tupaia belangeri	90.43	9.00e-124	438.00
IUUC-Ttr-128210	Tursiops truncatus	87.82	0.00e+00	1492.00
IUUC-Vpa-130222	Vicugna pacos	83.91	0.00e+00	781.00
IUUC-Xtr-132509	Xenopus tropicalis	64.16	0.00e+00	1317.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence