iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090029

Ensembl Protein ID

ENSOARP00000005469.1

UniProt Accession

W5P4W6; W5P4W6_SHEEP

Genbank Protein ID

ENSOARP00000005469

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01058651

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000005094.1	ENSOART00000005556.1	ENSOARP00000005469.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	9.10e-144	480.6	962	1512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++i+ed ++ ll+l+++l+ a+R+++++++++l++ +++    
   Q: 962  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDIAED-RRGLLHLSSRLNGALRHEQNFASHFLPDEEAA---- 1026
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q+++ ++++ ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve+++++       + 
   Q: 1027 ----QALGKTCWEALVSPLVQNITCPDEEGVSPLgWLLDQYLECREAAHNPQSRAAAFSSRVRRLTHLLVHVEPCEAP-------PA 1102
           ....9*************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
           + a +r k++++ +++++L++r+l+  ++++l++++++++++q++ +lt+ ++++d   +V+r++e+++ lqk++se+F+++a+Fl 
   Q: 1103 VAASPRPKGRNRSHDWSSLATRGLPssIMRNLTRCWRAVVEQQVHSFLTSRWRDDD---FVPRYCEHFSNLQKASSELFGPRAAFLL 1186
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++ +++k ++l+aa+++E++Ar+iDq++++s ++g++++e++aql+++l+ + ++s++++   Fe+yY++++a+RLl   + 
   Q: 1187 ALQNGCAGALLKLPFLRAAHVSEQFARHIDQRIQGSrIGGARGMEMLAQLQRCLETVLIFSGLEIattFEHYYQHYMADRLLG--VG 1271
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+s+L ++ +++l++Se+l+rqF+                                            
   Q: 1272 SSWLEGAVLEQI----GPCFPSRLpQEILRSLSTSEELQRQFHvyqlqrldqellkledtekkiqvsrdasasgrghergtgeeael 1354
           ************....*********************************************************************** PP
   S: 453  .....................eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekh 506
                                e ++ ++e +++e+svlvLs+++Wpta  ++t  ++++LPa+l+ t++++++fY        le+ 
   Q: 1355 eagavaaaaaagvageeeeedESEDLYYEGAMPEVSVLVLSPRCWPTAsiCHTlnPRTCLPAYLRGTLNRYSNFYnkrqsypaLERA 1441
           ******************99999999**********************9999899******************************** PP
   S: 507  sgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..k 580
           ++R+LqW++ lgrael++    g ++l+Vst+Qm++LL+fn+ ++vsve+l + ++lp+++L++++++L+ss+   
   Q: 1442 PQRRLQWTW-LGRAELQF----GDQTLHVSTVQMWLLLHFNELKAVSVESLLAHSGLPPDVLNQAIGPLTSSRgpL 1512
           *********.********....*************************************************98333 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPEELIRQRV GHDGHPEYQI RWLILRRGDD GEGGSNHVDC 60
KAEHILLWMS NDEIYANCHK MLGEDGQVIG PSQETAGEAG ALDKSVLGEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCGTCCCT TCCCGCGCGC CCCTGGCTTC TTCGGCCTTC CATCCTGGTT CCCCCAAACC 60
GCGCGCCCCT CATCCACCAG GTCTTCTGTG CACACTGTTC GGGGTCCTCA CGTCGCCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0000226--P:microtubule cytoskeleton organization
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

oas:101112931

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	88.06	0.00e+00	2801.00
IUUC-Bta-013285	Bos taurus	95.33	0.00e+00	3088.00
IUUC-Cja-019033	Callithrix jacchus	82.02	0.00e+00	2620.00
IUUC-Cfa-020695	Canis familiaris	85.54	0.00e+00	1746.00
IUUC-Cpo-021513	Cavia porcellus	78.39	0.00e+00	2495.00
IUUC-Csa-023798	Chlorocebus sabaeus	85.35	0.00e+00	2729.00
IUUC-Dor-030234	Dipodomys ordii	82.47	0.00e+00	2745.00
IUUC-Ete-032612	Echinops telfairi	76.26	0.00e+00	906.00
IUUC-Eca-033408	Equus caballus	90.11	0.00e+00	2804.00
IUUC-Fca-035483	Felis catus	87.62	0.00e+00	2815.00
IUUC-Gmo-038795	Gadus morhua	46.64	0.00e+00	942.00
IUUC-Gac-041628	Gasterosteus aculeatus	48.31	0.00e+00	1162.00
IUUC-Ggo-044721	Gorilla gorilla	85.77	0.00e+00	2708.00
IUUC-Hsa-046406	Homo sapiens	85.95	0.00e+00	2740.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	84.89	0.00e+00	2704.00
IUUC-Lch-049956	Latimeria chalumnae	43.71	0.00e+00	1048.00
IUUC-Laf-054068	Loxodonta africana	86.32	0.00e+00	2787.00
IUUC-Mcc-055464	Macaca mulatta	85.65	0.00e+00	2720.00
IUUC-Meu-056198	Macropus eugenii	57.25	0.00e+00	1307.00
IUUC-Mmr-061464	Microcebus murinus	85.36	0.00e+00	2724.00
IUUC-Mdo-062018	Monodelphis domestica	59.79	0.00e+00	1377.00
IUUC-Mmu-063413	Mus musculus	76.96	0.00e+00	2369.00
IUUC-Mpu-066146	Mustela putorius furo	88.52	0.00e+00	2727.00
IUUC-Mlu-067036	Myotis lucifugus	85.92	0.00e+00	2778.00
IUUC-Opr-070670	Ochotona princeps	77.26	0.00e+00	2452.00
IUUC-Oan-073451	Ornithorhynchus anatinus	51.51	0.00e+00	1167.00
IUUC-Ocu-074155	Oryctolagus cuniculus	83.67	0.00e+00	2642.00
IUUC-Oga-089084	Otolemur garnettii	85.08	0.00e+00	2796.00
IUUC-Ptr-091282	Pan troglodytes	84.48	0.00e+00	2723.00
IUUC-Pan-091883	Papio anubis	85.76	0.00e+00	2749.00
IUUC-Pab-098383	Pongo abelii	82.81	0.00e+00	2653.00
IUUC-Pca-100519	Procavia capensis	75.08	0.00e+00	820.00
IUUC-Pva-102417	Pteropus vampyrus	84.81	0.00e+00	2256.00
IUUC-Rno-105962	Rattus norvegicus	77.33	0.00e+00	2478.00
IUUC-Sar-113750	Sorex araneus	80.73	2.00e-171	597.00
IUUC-Ssc-115899	Sus scrofa	82.52	0.00e+00	2499.00
IUUC-Tsy-118860	Tarsius syrichta	82.53	0.00e+00	1111.00
IUUC-Tbe-127660	Tupaia belangeri	84.23	0.00e+00	1395.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence