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Tag Content
UUCD2 ID IUUC-Mlu-068119
UUCD1 version UUC-MyL-01197
Ensembl Protein ID ENSMLUP00000006170.2
UniProt Accession G1P7R0; G1P7R0_MYOLU
Genbank Protein ID ENSMLUP00000006170
Protein Name PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2
Genbank Nucleotide ID AAPE02026863
Gene Name PAN2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMLUG00000006737.2 ENSMLUT00000006758.2 ENSMLUP00000006170.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.30e-22 80.5 525 919
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 525  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 604
           56*********************...55654......57*************9****************99999866777777766666 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++++        +e  +  +    a+++  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 605  gkGNLARLIQRWNRFILTQLHQDMQE--------LEVPQ--AYRGAASSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 682
           66666666777888888888888833........22222..3444578899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+     e+ +   + +c++c+k+q + ++  +++lP++L+++    s +e+   r  ++  v f+  ++ 
   Q: 683  TLSYPEDKTGKNCDFAQVLKRSICLEQNT---QAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSLKEADFWR--MQADVAFKMAIKK 766
           *******************9888766665...69*******************************998887776..7777777744444 PP
   S: 262  spfcts............................................peekqke..........................kkkYeL 280
            +   +                                            +     +                           + Y+L
   Q: 767  HS--GEiskntelaladwkelgspegmlrcpsieelknvwlpfsirmkltK-----NkgldvcnwtdgdemqwgparaeeehgVYVYDL 848
           43..33223455555555555666666655555555555555555555550.....0555555555555555555555555669***** PP
   S: 281  iavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg..staYvlfYkr 337
           +a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++    + + +l+Y++
   Q: 849  MATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDMnwKVPAILYYTK 919
           ********9*************999988877777888*************999988766666666666665 PP
   
Organism Myotis lucifugus
Functional Description
(View)

Functional Description


     Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
 Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Protein Sequence
(Fasta)
MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVTVSH FDLHEEMLWV GSHGGHATSF FGPTLERYSS FQVNSSDEIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mlu-068119|DUB,USP|Myotis lucifugus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCCTGCTGA AGGTTGGGGT CAGGCATCTA AAGGGGCTGT GGCAAAGTAG GGTGTGACAC 60
GGGTCCAATC TGCTGCAATC ATCATGAACT TCGAGGGTCT GGACCCTGGA CTGGCAGAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mlu-068119|DUB,USP|Myotis lucifugus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50235--USP_3
Pfam

PF00929--RNase_T
PF13423--UCH_1
SMART

SM00479--EXOIII
Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001273 Ailuropoda melanoleuca 97.42 0.00e+00 2319.00
IUUC-Apl-003500 Anas platyrhynchos 85.41 0.00e+00 1882.00
IUUC-Aca-004930 Anolis carolinensis 83.42 0.00e+00 2011.00
IUUC-Acl-008214 Aspergillus clavatus 31.26 9.00e-156 544.00
IUUC-Afu-009112 Aspergillus fumigatus 31.25 4.00e-147 515.00
IUUC-Ang-009531 Aspergillus niger 30.59 7.00e-148 518.00
IUUC-Ame-011259 Astyanax mexicanus 76.01 0.00e+00 1849.00
IUUC-Bta-012371 Bos taurus 98.00 0.00e+00 2331.00
IUUC-Bci-013684 Botrytis cinerea 31.04 6.00e-134 472.00
IUUC-Cja-019297 Callithrix jacchus 94.52 0.00e+00 2251.00
IUUC-Cfa-020489 Canis familiaris 97.08 0.00e+00 2302.00
IUUC-Cpo-022392 Cavia porcellus 95.42 0.00e+00 2287.00
IUUC-Csa-023220 Chlorocebus sabaeus 96.76 0.00e+00 2308.00
IUUC-Csv-025841 Ciona savignyi 46.10 2.00e-136 480.00
IUUC-Cgl-026534 Colletotrichum gloeosporioides 32.30 9.00e-164 571.00
IUUC-Cne-026932 Cryptococcus neoformans 42.94 7.00e-73 269.00
IUUC-Dre-028482 Danio rerio 74.17 0.00e+00 1796.00
IUUC-Dno-029398 Dasypus novemcinctus 96.08 0.00e+00 2274.00
IUUC-Dor-030307 Dipodomys ordii 89.84 0.00e+00 1278.00
IUUC-Dme-032111 Drosophila melanogaster 40.97 0.00e+00 878.00
IUUC-Eca-033985 Equus caballus 98.00 0.00e+00 2326.00
IUUC-Eeu-034928 Erinaceus europaeus 83.40 0.00e+00 770.00
IUUC-Fca-035587 Felis catus 97.25 0.00e+00 2335.00
IUUC-Fal-037587 Ficedula albicollis 84.04 0.00e+00 1994.00
IUUC-Fso-038133 Fusarium solani 29.49 4.00e-133 469.00
IUUC-Gmo-039076 Gadus morhua 73.89 0.00e+00 1760.00
IUUC-Ggr-039957 Gaeumannomyces graminis 32.12 3.00e-143 503.00
IUUC-Gga-040948 Gallus gallus 85.18 0.00e+00 2041.00
IUUC-Gac-042396 Gasterosteus aculeatus 74.57 0.00e+00 1811.00
IUUC-Ggo-045412 Gorilla gorilla 96.76 0.00e+00 2304.00
IUUC-Hsa-046076 Homo sapiens 96.76 0.00e+00 2309.00
IUUC-Itr-048143 Ictidomys tridecemlineatus 89.72 0.00e+00 2079.00
IUUC-Kpa-049178 Komagataella pastoris 39.88 4.00e-66 246.00
IUUC-Lch-050279 Latimeria chalumnae 71.86 0.00e+00 1714.00
IUUC-Loc-052872 Lepisosteus oculatus 76.30 0.00e+00 1836.00
IUUC-Lma-052986 Leptosphaeria maculans 32.41 2.00e-159 556.00
IUUC-Laf-054181 Loxodonta africana 94.85 0.00e+00 2265.00
IUUC-Mcc-054812 Macaca mulatta 97.08 0.00e+00 2306.00
IUUC-Meu-056325 Macropus eugenii 91.35 0.00e+00 2170.00
IUUC-Mor-057246 Magnaporthe oryzae 29.34 2.00e-126 447.00
IUUC-Mpo-057464 Magnaporthe poae 31.69 1.00e-145 511.00
IUUC-Mla-058911 Melampsora laricipopulina 31.92 4.00e-102 366.00
IUUC-Mga-059335 Meleagris gallopavo 85.52 0.00e+00 1991.00
IUUC-Mvi-060461 Microbotryum violaceum 33.70 3.00e-144 506.00
IUUC-Mmr-060636 Microcebus murinus 96.99 0.00e+00 2303.00
IUUC-Mmu-063503 Mus musculus 94.36 0.00e+00 2249.00
IUUC-Mpu-066670 Mustela putorius furo 98.00 0.00e+00 2327.00
IUUC-Nfi-068398 Neosartorya fischeri 31.93 5.00e-156 545.00
IUUC-Ncr-068927 Neurospora crassa 30.18 1.00e-131 464.00
IUUC-Nle-069651 Nomascus leucogenys 92.68 0.00e+00 2204.00
IUUC-Opr-070614 Ochotona princeps 95.60 0.00e+00 2248.00
IUUC-Ont-072433 Oreochromis niloticus 74.90 0.00e+00 1863.00
IUUC-Oan-073283 Ornithorhynchus anatinus 73.32 0.00e+00 1413.00
IUUC-Ocu-074401 Oryctolagus cuniculus 95.77 0.00e+00 2280.00
IUUC-Ola-087522 Oryzias latipes 74.55 0.00e+00 1808.00
IUUC-Oga-088226 Otolemur garnettii 95.94 0.00e+00 2310.00
IUUC-Oar-089241 Ovis aries 97.59 0.00e+00 2348.00
IUUC-Pan-092297 Papio anubis 97.26 0.00e+00 2065.00
IUUC-Psi-094043 Pelodiscus sinensis 81.88 0.00e+00 1918.00
IUUC-Pma-094394 Petromyzon marinus 68.49 0.00e+00 1555.00
IUUC-Pno-095053 Phaeosphaeria nodorum 32.26 4.00e-149 522.00
IUUC-Ppa-095188 Physcomitrella patens 32.59 1.00e-162 567.00
IUUC-Pfo-097517 Poecilia formosa 75.45 0.00e+00 1868.00
IUUC-Pca-100471 Procavia capensis 96.20 0.00e+00 2145.00
IUUC-Pva-102805 Pteropus vampyrus 93.40 0.00e+00 1821.00
IUUC-Pte-104021 Pyrenophora teres 32.06 5.00e-162 565.00
IUUC-Pyt-104682 Pyrenophora triticirepentis 31.88 9.00e-161 561.00
IUUC-Rno-105471 Rattus norvegicus 94.49 0.00e+00 2251.00
IUUC-Sce-106235 Saccharomyces cerevisiae 38.55 6.00e-61 229.00
IUUC-Sha-106883 Sarcophilus harrisii 89.79 0.00e+00 1997.00
IUUC-Spo-108169 Schizosaccharomyces pombe 31.51 5.00e-144 505.00
IUUC-Sar-113323 Sorex araneus 95.85 0.00e+00 1697.00
IUUC-Sre-115075 Sporisorium reilianum 29.11 2.00e-66 248.00
IUUC-Ssc-116363 Sus scrofa 96.60 0.00e+00 2327.00
IUUC-Tru-118427 Takifugu rubripes 75.06 0.00e+00 1886.00
IUUC-Tni-120218 Tetraodon nigroviridis 75.33 0.00e+00 1879.00
IUUC-Tre-122177 Trichoderma reesei 31.89 3.00e-153 536.00
IUUC-Tme-127176 Tuber melanosporum 32.35 4.00e-143 502.00
IUUC-Tbe-127641 Tupaia belangeri 87.42 0.00e+00 801.00
IUUC-Ttr-128888 Tursiops truncatus 96.66 0.00e+00 1456.00
IUUC-Uma-129361 Ustilago maydis 38.12 4.00e-63 237.00
IUUC-Xtr-132811 Xenopus tropicalis 79.20 0.00e+00 1894.00
Created Date 25-Jun-2017

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