iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089241

Ensembl Protein ID

ENSOARP00000010076.1

UniProt Accession

W5PI08; W5PI08_SHEEP

Genbank Protein ID

ENSOARP00000010076

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AMGL01081590

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000009379.1	ENSOART00000010222.1	ENSOARP00000010076.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-20	72.6	525	911

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 525  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 604
           56*********************...55654......57*************9****************99999866777777777776 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql+++l++        +e  +  +      ++  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 605  gkGNLARLIQRWNRFILTQLHQDLQE--------LEVPQ--AYRGAGGSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 682
           66667777778888999999999933........22222..3344467899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeee.legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           +l+ p+ ++++k+  +  +++  k+   le++ + +c++c+k+q + ++  +++lP++L+++    s +e+   r  ++ +v f+  + 
   Q: 683  TLSYPEGSNSDKTGKNCDFAQVLKRSIcLEQNTQAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSLKEADFWR--MQAEVAFKMAI- 768
           *****888766663333345555444326666679*******************************988887765..88888887444. PP
   S: 261  lspfcts........peekqke..............................................................kkkYe 279
            +++  +                                                                              + Y+
   Q: 769  -KKHSGEisknkefaL-----AdwkelgspegmlmcpsieelknvwlpfsiqmkmtknkgldvcnwtdgdemqwgparaeeehgVYVYD 851
           .444444223445550.....1555555555555555555555555555555555555666666666666666666666666669**** PP
   S: 280  LiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
           L+a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 852  LMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 911
           *********9*************999988877777888************9999888654 PP

Organism

Ovis aries

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPTLERYSS FQVNGSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCAGGATGT GCATTCTAGG TCCACTGATG TCCTGCTGAA GGTTGGGTCA GGCATCCAAA 60
GGGGCTGTGG CAAGGGAGGG TGTGTGACAC GGGTCAGTCT GCTGCTATCG TCATCATCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	98.50	0.00e+00	2365.00
IUUC-Apl-003500	Anas platyrhynchos	85.88	0.00e+00	1889.00
IUUC-Aca-004930	Anolis carolinensis	83.95	0.00e+00	2018.00
IUUC-Acl-008214	Aspergillus clavatus	31.33	2.00e-156	546.00
IUUC-Afu-009112	Aspergillus fumigatus	31.61	7.00e-148	518.00
IUUC-Ang-009531	Aspergillus niger	31.18	2.00e-149	523.00
IUUC-Ame-011259	Astyanax mexicanus	76.45	0.00e+00	1838.00
IUUC-Bta-012371	Bos taurus	99.25	0.00e+00	2372.00
IUUC-Bci-013684	Botrytis cinerea	31.13	6.00e-134	472.00
IUUC-Cja-019297	Callithrix jacchus	95.27	0.00e+00	2294.00
IUUC-Cfa-020489	Canis familiaris	97.67	0.00e+00	2335.00
IUUC-Cpo-022392	Cavia porcellus	96.34	0.00e+00	2335.00
IUUC-Csa-023220	Chlorocebus sabaeus	98.00	0.00e+00	2356.00
IUUC-Csv-025841	Ciona savignyi	45.67	0.00e+00	904.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.56	4.00e-164	572.00
IUUC-Cne-026932	Cryptococcus neoformans	42.94	5.00e-73	270.00
IUUC-Dre-028482	Danio rerio	74.34	0.00e+00	1788.00
IUUC-Dno-029398	Dasypus novemcinctus	96.76	0.00e+00	2308.00
IUUC-Dor-030307	Dipodomys ordii	90.55	0.00e+00	1316.00
IUUC-Dme-032111	Drosophila melanogaster	40.80	0.00e+00	878.00
IUUC-Eca-033985	Equus caballus	98.84	0.00e+00	2362.00
IUUC-Eeu-034928	Erinaceus europaeus	84.62	0.00e+00	776.00
IUUC-Fca-035587	Felis catus	98.50	0.00e+00	2368.00
IUUC-Fal-037587	Ficedula albicollis	84.57	0.00e+00	1984.00
IUUC-Fso-038133	Fusarium solani	29.61	9.00e-133	468.00
IUUC-Gmo-039076	Gadus morhua	74.30	0.00e+00	1752.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.29	8.00e-142	498.00
IUUC-Gga-040948	Gallus gallus	85.70	0.00e+00	2065.00
IUUC-Gac-042396	Gasterosteus aculeatus	74.73	0.00e+00	1801.00
IUUC-Ggo-045412	Gorilla gorilla	97.84	0.00e+00	2351.00
IUUC-Hsa-046076	Homo sapiens	97.84	0.00e+00	2357.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	90.26	0.00e+00	2109.00
IUUC-Kpa-049178	Komagataella pastoris	40.48	7.00e-67	249.00
IUUC-Lch-050279	Latimeria chalumnae	72.75	0.00e+00	1717.00
IUUC-Loc-052872	Lepisosteus oculatus	76.87	0.00e+00	1844.00
IUUC-Lma-052986	Leptosphaeria maculans	32.50	1.00e-158	554.00
IUUC-Laf-054181	Loxodonta africana	95.45	0.00e+00	2297.00
IUUC-Mcc-054812	Macaca mulatta	97.75	0.00e+00	2340.00
IUUC-Meu-056325	Macropus eugenii	92.10	0.00e+00	2213.00
IUUC-Mor-057246	Magnaporthe oryzae	29.41	5.00e-126	445.00
IUUC-Mpo-057464	Magnaporthe poae	31.87	3.00e-144	506.00
IUUC-Mla-058911	Melampsora laricipopulina	32.60	3.00e-101	363.00
IUUC-Mga-059335	Meleagris gallopavo	86.23	0.00e+00	2021.00
IUUC-Mvi-060461	Microbotryum violaceum	34.34	3.00e-145	509.00
IUUC-Mmr-060636	Microcebus murinus	97.67	0.00e+00	2336.00
IUUC-Mmu-063503	Mus musculus	94.87	0.00e+00	2261.00
IUUC-Mpu-066670	Mustela putorius furo	98.50	0.00e+00	2357.00
IUUC-Mlu-068119	Myotis lucifugus	97.59	0.00e+00	2375.00
IUUC-Nfi-068398	Neosartorya fischeri	32.28	4.00e-157	549.00
IUUC-Ncr-068927	Neurospora crassa	29.92	5.00e-130	459.00
IUUC-Nle-069651	Nomascus leucogenys	94.01	0.00e+00	2253.00
IUUC-Opr-070614	Ochotona princeps	96.51	0.00e+00	2287.00
IUUC-Ont-072433	Oreochromis niloticus	74.98	0.00e+00	1855.00
IUUC-Oan-073283	Ornithorhynchus anatinus	73.63	0.00e+00	1420.00
IUUC-Ocu-074401	Oryctolagus cuniculus	96.12	0.00e+00	2308.00
IUUC-Ola-087522	Oryzias latipes	74.71	0.00e+00	1799.00
IUUC-Oga-088226	Otolemur garnettii	96.29	0.00e+00	2320.00
IUUC-Pan-092297	Papio anubis	97.74	0.00e+00	2095.00
IUUC-Psi-094043	Pelodiscus sinensis	82.41	0.00e+00	1924.00
IUUC-Pma-094394	Petromyzon marinus	68.98	0.00e+00	1554.00
IUUC-Pno-095053	Phaeosphaeria nodorum	32.08	5.00e-149	521.00
IUUC-Ppa-095188	Physcomitrella patens	32.49	2.00e-158	553.00
IUUC-Pfo-097517	Poecilia formosa	75.54	0.00e+00	1853.00
IUUC-Pca-100471	Procavia capensis	97.29	0.00e+00	2192.00
IUUC-Pva-102805	Pteropus vampyrus	94.42	0.00e+00	1867.00
IUUC-Pte-104021	Pyrenophora teres	32.23	3.00e-161	562.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	32.05	3.00e-160	559.00
IUUC-Rno-105471	Rattus norvegicus	95.01	0.00e+00	2264.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.05	9.00e-61	228.00
IUUC-Sha-106883	Sarcophilus harrisii	91.14	0.00e+00	2039.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.00	6.00e-142	498.00
IUUC-Sar-113323	Sorex araneus	95.75	0.00e+00	1724.00
IUUC-Sre-115075	Sporisorium reilianum	29.49	4.00e-69	257.00
IUUC-Ssc-116363	Sus scrofa	97.60	0.00e+00	2364.00
IUUC-Tru-118427	Takifugu rubripes	75.08	0.00e+00	1872.00
IUUC-Tni-120218	Tetraodon nigroviridis	75.43	0.00e+00	1867.00
IUUC-Tre-122177	Trichoderma reesei	31.98	1.00e-152	533.00
IUUC-Tme-127176	Tuber melanosporum	32.66	3.00e-139	489.00
IUUC-Tbe-127641	Tupaia belangeri	88.03	0.00e+00	803.00
IUUC-Ttr-128888	Tursiops truncatus	98.40	0.00e+00	1506.00
IUUC-Uma-129361	Ustilago maydis	38.42	3.00e-63	238.00
IUUC-Xtr-132811	Xenopus tropicalis	79.34	0.00e+00	1901.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence