iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000025804.1	ENSSTOT00000028703.1	ENSSTOP00000015486.1
ENSSTOG00000025804.1	ENSSTOT00000020979.1	ENSSTOP00000016303.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.10e-07	29.7	291	330

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+ kd +++ pCgH+ + +Cl +w     +   +++CP Cr
   Q: 291  CKICAERDKD-VRIEPCGHLLCSHCLAAW-----QHAESQTCPFCR 330
           99********.******************.....6788999****8 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

ARRAAGGDGP EGPGGAGDFL MVYLANLESK GRQVAELLPP RGKRGANDEL FREGSRLRRQ 60
LAKLALLFSH MHAELSALFP GGKYCGHVYQ LTKAQAHTFW RERCGARCVL PWAEFQSLLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCGACCTC TAACCCCACG CCACCACCAA AGACTCAGGC CTTCGGCCAC GACTCGAGGT 60
TCTACTTTGG AGAGCTAGCT TCCCACCCTT GTGGATCCCG TGCCCAACAA AGGTCCCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	76.85	0.00e+00	626.00
IUUC-Bta-012705	Bos taurus	79.57	0.00e+00	655.00
IUUC-Cja-019179	Callithrix jacchus	82.91	5.00e-176	610.00
IUUC-Cfa-020593	Canis familiaris	74.76	9.00e-172	596.00
IUUC-Cpo-021289	Cavia porcellus	79.42	2.00e-159	555.00
IUUC-Csa-023966	Chlorocebus sabaeus	76.85	2.00e-178	618.00
IUUC-Dor-030246	Dipodomys ordii	83.33	2.00e-110	392.00
IUUC-Eca-033921	Equus caballus	73.63	3.00e-144	504.00
IUUC-Fca-035747	Felis catus	73.13	3.00e-158	551.00
IUUC-Ggo-044622	Gorilla gorilla	83.65	5.00e-157	546.00
IUUC-Hsa-045735	Homo sapiens	83.48	4.00e-177	613.00
IUUC-Laf-053983	Loxodonta africana	76.82	0.00e+00	645.00
IUUC-Mmr-061310	Microcebus murinus	79.43	3.00e-177	614.00
IUUC-Mmu-064155	Mus musculus	76.01	3.00e-176	610.00
IUUC-Mpu-066655	Mustela putorius furo	82.84	1.00e-168	585.00
IUUC-Mlu-067929	Myotis lucifugus	82.72	4.00e-152	530.00
IUUC-Nle-070065	Nomascus leucogenys	67.48	2.00e-132	464.00
IUUC-Ocu-074049	Oryctolagus cuniculus	71.13	2.00e-134	471.00
IUUC-Oga-087952	Otolemur garnettii	82.50	0.00e+00	640.00
IUUC-Oar-089382	Ovis aries	77.16	1.00e-175	608.00
IUUC-Ptr-090579	Pan troglodytes	69.78	4.00e-126	443.00
IUUC-Pan-092075	Papio anubis	83.19	1.00e-176	612.00
IUUC-Pab-098100	Pongo abelii	73.17	1.00e-146	512.00
IUUC-Pca-100830	Procavia capensis	82.87	6.00e-89	320.00
IUUC-Pva-102714	Pteropus vampyrus	74.67	5.00e-134	470.00
IUUC-Pgr-103631	Puccinia graminis	42.00	6.00e-06	43.50
IUUC-Rno-105348	Rattus norvegicus	74.11	5.00e-176	610.00
IUUC-Sha-107138	Sarcophilus harrisii	64.91	2.00e-128	451.00
IUUC-Ssc-116424	Sus scrofa	76.61	0.00e+00	635.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence