iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/ULP	3.50e-54	184.7	395	557

Active Site

Position(s)	Description	Evidence
477	N/A	{ECO:0000250}
494		{ECO:0000250}
547	Nucleophile	N/A

Domain Profile

DUB/ULP

   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpineaaHWslav 90
            +t+ d+++L++ ++lnD++i+fy++ l++e+ kk+ ++ +h+fs+ffy klk+ ++++vk+wt+ v+lfe++l++vpi++++HWsl+v
   Q: 395  RITRGDIQTLKNYHWLNDEVINFYMN-LLVERSKKQGYPALHAFSTFFYPKLKSGGYQAVKRWTKGVNLFEQELVLVPIHRKVHWSLVV 482
           699***********************.9999********************************************************** PP
   S: 91   vcfkkksilllDSlrgasksnvvkklreylevevkkkskrefskeklkgsnpk...vpqQkNssDCGvyvlqyves 163
           ++++kk++ +lDS+ g++ ++++++l +yl++e+k+k++ +++  ++ ++++k   +pqQ N+sDCG++ ++y+++
   Q: 483  MDLRKKCLKYLDSM-GQKGHRICEILLQYLQDESKTKRNTDLNLLEWTHYSMKpheIPQQLNGSDCGMFTCKYADY 557
           **************.********************************999988889*****************986 PP

Organism

Mus musculus

Functional Description
(View)

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Isoform 3 activates transcription.

Protein Sequence
(Fasta)

MYRWLAKVLG TILRLCERPA PGARALLKRR RSSSTLFSTA VDTDEIPAKR PRLDCFIHQV 60
KNSLYNAASL FGFPFQLTTK PMVSSACNGT RNVAPSGEVF SNSSSCELMS SGSCSSMLKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGTCCGCGC CTGATCCTGG CTACGGCTGA AGCGGCGAAG GCGGCAGCGG CAGCGGCAGC 60
GGCAGCGGCG ACGGCGGCGG CGGCGGCGGC GGCGGCGGCG ACAGCTCTGG GGTTCGCGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0811--Translocation
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0004175--F:endopeptidase activity
GO:0070139--F:SUMO-specific endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0009950--P:dorsal/ventral axis specification
GO:0045444--P:fat cell differentiation
GO:0007507--P:heart development
GO:0060711--P:labyrinthine layer development
GO:0051028--P:mRNA transport
GO:0035562--P:negative regulation of chromatin binding
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0032091--P:negative regulation of protein binding
GO:0031397--P:negative regulation of protein ubiquitination
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0001934--P:positive regulation of protein phosphorylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0031648--P:protein destabilization
GO:0016926--P:protein desumoylation
GO:0015031--P:protein transport
GO:0032875--P:regulation of DNA endoreduplication
GO:2000045--P:regulation of G1/S transition of mitotic cell cycle
GO:0060712--P:spongiotrophoblast layer development
GO:0006351--P:transcription, DNA-templated
GO:0060707--P:trophoblast giant cell differentiation
GO:0016055--P:Wnt signaling pathway

KEGG

mmu:75826

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001512	Ailuropoda melanoleuca	86.29	0.00e+00	988.00
IUUC-Apl-003602	Anas platyrhynchos	52.22	2.00e-121	429.00
IUUC-Aca-004819	Anolis carolinensis	45.04	3.00e-105	375.00
IUUC-Afl-008417	Aspergillus flavus	30.94	3.00e-30	127.00
IUUC-Aor-010104	Aspergillus oryzae	32.04	2.00e-29	122.00
IUUC-Ame-011519	Astyanax mexicanus	40.20	3.00e-74	273.00
IUUC-Bta-013157	Bos taurus	85.76	0.00e+00	984.00
IUUC-Cja-018720	Callithrix jacchus	87.14	0.00e+00	1002.00
IUUC-Cfa-020805	Canis familiaris	87.48	0.00e+00	998.00
IUUC-Cpo-021808	Cavia porcellus	86.10	0.00e+00	1001.00
IUUC-Cho-024783	Choloepus hoffmanni	63.49	1.00e-167	582.00
IUUC-Dno-028882	Dasypus novemcinctus	87.29	0.00e+00	1004.00
IUUC-Dor-030693	Dipodomys ordii	67.40	0.00e+00	701.00
IUUC-Ete-032724	Echinops telfairi	72.37	0.00e+00	812.00
IUUC-Eca-034052	Equus caballus	87.80	0.00e+00	1009.00
IUUC-Eeu-034465	Erinaceus europaeus	85.20	0.00e+00	890.00
IUUC-Fca-036319	Felis catus	87.31	0.00e+00	1001.00
IUUC-Fal-037347	Ficedula albicollis	60.53	1.00e-85	309.00
IUUC-Gga-041045	Gallus gallus	49.77	3.00e-102	365.00
IUUC-Ggo-044694	Gorilla gorilla	81.02	0.00e+00	902.00
IUUC-Hsa-045920	Homo sapiens	87.97	0.00e+00	1007.00
IUUC-Itr-048799	Ictidomys tridecemlineatus	88.81	0.00e+00	1019.00
IUUC-Lch-049790	Latimeria chalumnae	64.10	2.00e-90	325.00
IUUC-Laf-053368	Loxodonta africana	84.75	0.00e+00	977.00
IUUC-Mcc-055057	Macaca mulatta	87.63	0.00e+00	1006.00
IUUC-Meu-056435	Macropus eugenii	55.14	9.00e-175	606.00
IUUC-Mmr-061684	Microcebus murinus	88.81	0.00e+00	1025.00
IUUC-Mdo-062858	Monodelphis domestica	69.21	2.00e-132	465.00
IUUC-Mpu-066611	Mustela putorius furo	84.52	0.00e+00	947.00
IUUC-Mlu-067118	Myotis lucifugus	82.21	0.00e+00	999.00
IUUC-Nle-069443	Nomascus leucogenys	87.97	0.00e+00	1008.00
IUUC-Opr-070806	Ochotona princeps	76.62	0.00e+00	861.00
IUUC-Oan-073590	Ornithorhynchus anatinus	55.60	2.00e-74	272.00
IUUC-Ocu-073901	Oryctolagus cuniculus	86.13	0.00e+00	1004.00
IUUC-Oga-089135	Otolemur garnettii	87.97	0.00e+00	1009.00
IUUC-Oar-089942	Ovis aries	86.78	0.00e+00	1003.00
IUUC-Ptr-090705	Pan troglodytes	87.97	0.00e+00	1009.00
IUUC-Pan-092887	Papio anubis	86.99	0.00e+00	822.00
IUUC-Psi-093140	Pelodiscus sinensis	51.48	4.00e-142	498.00
IUUC-Pno-094805	Phaeosphaeria nodorum	32.81	2.00e-22	100.00
IUUC-Pab-098511	Pongo abelii	89.76	6.00e-148	517.00
IUUC-Pca-100253	Procavia capensis	60.74	1.00e-171	596.00
IUUC-Ppe-101189	Prunus persica	40.00	2.00e-33	137.00
IUUC-Pva-103179	Pteropus vampyrus	85.42	0.00e+00	969.00
IUUC-Pte-104020	Pyrenophora teres	33.33	3.00e-18	87.40
IUUC-Rno-105258	Rattus norvegicus	96.60	0.00e+00	1090.00
IUUC-Sha-107397	Sarcophilus harrisii	39.05	1.00e-92	334.00
IUUC-Sar-113372	Sorex araneus	84.66	0.00e+00	853.00
IUUC-Ssc-115700	Sus scrofa	85.33	0.00e+00	965.00
IUUC-Tgu-117433	Taeniopygia guttata	60.79	4.00e-85	307.00
IUUC-Tsy-118960	Tarsius syrichta	78.54	0.00e+00	776.00
IUUC-Tbe-127893	Tupaia belangeri	61.40	2.00e-173	602.00
IUUC-Ttr-128910	Tursiops truncatus	89.03	0.00e+00	942.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence