iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028062

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 variant 2

Genbank Nucleotide ID

BC058061

Gene Name

ube2v2; zgc:63717

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000028198.6	ENSDART00000026578.7	ENSDARP00000004795.7

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UEV	1.70e-65	220.2	4	143
E2/UBC	5.80e-19	69.1	30	136

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UEV

   S: 6    elkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevn 94
            + v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp rt+ye+rIy+lk+++g+kYPe PPtvrf++ki m+++n
   Q: 4    SSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPARTNYENRIYSLKVECGPKYPEVPPTVRFVTKISMNGIN 92
           5789************************************************************************************* PP
   S: 95   dsnGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           +snG+vd+r++p+La+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 93   NSNGMVDARSIPILAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTY 143
           ************************************************986 PP

E2/UBC

   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsv 98
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l++e+ ++YP  PP+v+f+tki    ++++ G v    + il    kW+  +s+
   Q: 30   TVSWGLEDDEDmtLTRWTGMIIGPARTNYENRIYSLKVECGPKYPEVPPTVRFVTKISMNGINNSnGMVdarSIPIL---AKWQNSYSI 115
           456667777776689*****************************************988888777699955557888...5******** PP
   S: 99   esvllsiqsll.aepnpespl 118
           + vl ++ +l+ ++ n++ p+
   Q: 116  KVVLQELRRLMmSKENMKLPQ 136
           *********996667777775 PP

Organism

Danio rerio

Functional Description
(View)

Has no ubiquitin ligase activity on its own. The ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).

Protein Sequence
(Fasta)

MAASSGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPARTNYEN 60
RIYSLKVECG PKYPEVPPTV RFVTKISMNG INNSNGMVDA RSIPILAKWQ NSYSIKVVLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTGGATTC GGGCAGGAGA AGATGGCGGC CTCCTCAGGT TTGTCTGACA ATTTCTTCAA 60
TCCTCGCGCC CCTCCGCTGA CTTATTTTCA CAACAAAATA GCCGAGCTCG TTCCACACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination

KEGG

dre:406836

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000910	Aegilops tauschii	49.65	8.00e-37	145.00
IUUC-Aml-001275	Ailuropoda melanoleuca	95.00	9.00e-77	278.00
IUUC-Atr-003059	Amborella trichopoda	50.76	1.00e-35	142.00
IUUC-Apl-003790	Anas platyrhynchos	95.74	2.00e-69	253.00
IUUC-Aca-004448	Anolis carolinensis	94.96	1.00e-67	248.00
IUUC-Aly-006356	Arabidopsis lyrata	54.48	3.00e-37	147.00
IUUC-Ath-007596	Arabidopsis thaliana	50.00	4.00e-37	146.00
IUUC-Ago-007810	Ashbya gossypii	48.53	3.00e-32	130.00
IUUC-Acl-008375	Aspergillus clavatus	46.10	2.00e-31	128.00
IUUC-Afu-008838	Aspergillus fumigatus	46.38	4.00e-33	133.00
IUUC-Ani-009325	Aspergillus nidulans	49.65	7.00e-35	139.00
IUUC-Ang-009631	Aspergillus niger	48.55	1.00e-33	135.00
IUUC-Ate-010471	Aspergillus terreus	44.20	6.00e-28	115.00
IUUC-Bgr-012010	Blumeria graminis	49.64	3.00e-32	130.00
IUUC-Bta-012471	Bos taurus	93.79	9.00e-79	285.00
IUUC-Bci-013649	Botrytis cinerea	51.09	2.00e-31	128.00
IUUC-Bdi-014636	Brachypodium distachyon	50.75	1.00e-35	142.00
IUUC-Bol-015323	Brassica oleracea	50.00	2.00e-37	147.00
IUUC-Bra-017120	Brassica rapa	50.00	3.00e-37	147.00
IUUC-Cel-018398	Caenorhabditis elegans	64.49	1.00e-46	178.00
IUUC-Cja-019506	Callithrix jacchus	93.10	1.00e-78	284.00
IUUC-Cfa-020370	Canis familiaris	93.79	9.00e-79	285.00
IUUC-Cpo-021317	Cavia porcellus	92.41	8.00e-77	278.00
IUUC-Cre-022629	Chlamydomonas reinhardtii	48.18	2.00e-37	147.00
IUUC-Csa-023412	Chlorocebus sabaeus	93.79	9.00e-79	285.00
IUUC-Cho-025024	Choloepus hoffmanni	93.33	5.00e-47	178.00
IUUC-Cin-025219	Ciona intestinalis	48.08	1.00e-24	105.00
IUUC-Cgl-026596	Colletotrichum gloeosporioides	51.45	4.00e-35	140.00
IUUC-Cme-027257	Cyanidioschyzon merolae	52.14	6.00e-27	113.00
IUUC-Dno-029546	Dasypus novemcinctus	95.00	7.00e-77	279.00
IUUC-Ete-033017	Echinops telfairi	80.69	9.00e-64	237.00
IUUC-Eeu-035327	Erinaceus europaeus	86.90	9.00e-68	250.00
IUUC-Fca-035746	Felis catus	95.00	1.00e-76	278.00
IUUC-Fal-037369	Ficedula albicollis	95.10	5.00e-70	256.00
IUUC-Fox-037803	Fusarium oxysporum	50.72	2.00e-35	141.00
IUUC-Fso-038147	Fusarium solani	52.52	2.00e-37	147.00
IUUC-Gmo-039696	Gadus morhua	86.11	4.00e-70	256.00
IUUC-Ggr-039839	Gaeumannomyces graminis	46.05	9.00e-30	122.00
IUUC-Gga-040634	Gallus gallus	95.10	5.00e-70	256.00
IUUC-Gac-041936	Gasterosteus aculeatus	87.50	6.00e-65	239.00
IUUC-Gma-044162	Glycine max	49.30	2.00e-34	137.00
IUUC-Ggo-044696	Gorilla gorilla	93.79	9.00e-79	285.00
IUUC-Hsa-046699	Homo sapiens	93.79	9.00e-79	285.00
IUUC-Hvu-047307	Hordeum vulgare	50.71	1.00e-37	148.00
IUUC-Itr-048151	Ictidomys tridecemlineatus	93.79	9.00e-79	285.00
IUUC-Lch-050494	Latimeria chalumnae	79.58	7.00e-67	245.00
IUUC-Lpe-050874	Leersia perrieri	51.49	5.00e-37	146.00
IUUC-Loc-052012	Lepisosteus oculatus	98.62	7.00e-82	295.00
IUUC-Lma-053194	Leptosphaeria maculans	50.72	6.00e-35	139.00
IUUC-Laf-053991	Loxodonta africana	94.29	3.00e-76	276.00
IUUC-Mcc-055850	Macaca mulatta	95.00	6.00e-77	279.00
IUUC-Meu-056842	Macropus eugenii	75.56	1.00e-31	130.00
IUUC-Mor-056915	Magnaporthe oryzae	37.33	1.00e-20	92.40
IUUC-Mpo-057437	Magnaporthe poae	45.39	2.00e-29	121.00
IUUC-Mtr-058655	Medicago truncatula	50.69	6.00e-36	143.00
IUUC-Mla-058919	Melampsora laricipopulina	53.96	2.00e-34	137.00
IUUC-Mga-059210	Meleagris gallopavo	95.74	2.00e-69	253.00
IUUC-Mvi-060260	Microbotryum violaceum	51.09	6.00e-35	139.00
IUUC-Mmr-061751	Microcebus murinus	91.72	1.00e-76	278.00
IUUC-Mdo-062503	Monodelphis domestica	95.86	3.00e-72	263.00
IUUC-Mmu-063294	Mus musculus	92.41	7.00e-78	281.00
IUUC-Mac-065220	Musa acuminata	50.00	1.00e-37	148.00
IUUC-Mpu-065942	Mustela putorius furo	93.79	9.00e-79	285.00
IUUC-Mlu-067702	Myotis lucifugus	95.00	1.00e-76	278.00
IUUC-Nfi-068400	Neosartorya fischeri	41.05	9.00e-25	105.00
IUUC-Ncr-068946	Neurospora crassa	45.03	2.00e-35	141.00
IUUC-Nle-069327	Nomascus leucogenys	93.79	9.00e-79	285.00
IUUC-Opr-070697	Ochotona princeps	79.86	2.00e-60	224.00
IUUC-Ont-072098	Oreochromis niloticus	94.44	2.00e-70	257.00
IUUC-Oan-073215	Ornithorhynchus anatinus	92.96	3.00e-66	243.00
IUUC-Ocu-073859	Oryctolagus cuniculus	93.79	9.00e-79	285.00
IUUC-Oba-075005	Oryza barthii	50.75	2.00e-36	144.00
IUUC-Obr-076238	Oryza brachyantha	50.75	1.00e-36	145.00
IUUC-Ogl-077233	Oryza glaberrima	50.75	2.00e-36	144.00
IUUC-Ogu-078374	Oryza glumaepatula	50.75	2.00e-36	144.00
IUUC-Oin-079721	Oryza indica	50.75	2.00e-36	144.00
IUUC-Olo-080528	Oryza longistaminata	49.65	3.00e-35	140.00
IUUC-Ome-081761	Oryza meridionalis	50.75	1.00e-36	145.00
IUUC-Oni-082346	Oryza nivara	50.75	2.00e-36	144.00
IUUC-Opu-083148	Oryza punctata	50.75	2.00e-36	144.00
IUUC-Oru-084359	Oryza rufipogon	50.75	2.00e-36	144.00
IUUC-Osa-085664	Oryza sativa	50.75	2.00e-36	144.00
IUUC-Ola-087529	Oryzias latipes	90.97	2.00e-68	250.00
IUUC-Olu-087815	Ostreococcus lucimarinus	39.47	4.00e-20	90.50
IUUC-Oar-090010	Ovis aries	95.00	9.00e-77	278.00
IUUC-Ptr-091024	Pan troglodytes	95.00	9.00e-77	278.00
IUUC-Pan-091955	Papio anubis	93.79	9.00e-79	285.00
IUUC-Psi-093138	Pelodiscus sinensis	95.10	5.00e-70	256.00
IUUC-Pma-094142	Petromyzon marinus	77.19	2.00e-21	93.60
IUUC-Pno-095070	Phaeosphaeria nodorum	51.45	1.00e-35	142.00
IUUC-Ppa-095557	Physcomitrella patens	51.75	8.00e-40	155.00
IUUC-Pfo-096483	Poecilia formosa	95.14	9.00e-71	258.00
IUUC-Pab-098753	Pongo abelii	93.79	9.00e-79	285.00
IUUC-Pop-099786	Populus trichocarpa	49.30	3.00e-36	143.00
IUUC-Pca-100723	Procavia capensis	86.90	8.00e-68	250.00
IUUC-Ppe-101725	Prunus persica	53.24	2.00e-37	147.00
IUUC-Pva-102989	Pteropus vampyrus	93.79	9.00e-79	285.00
IUUC-Pgr-103617	Puccinia graminis	51.08	3.00e-32	130.00
IUUC-Ptt-104008	Puccinia triticina	43.48	8.00e-16	76.30
IUUC-Pte-104176	Pyrenophora teres	50.00	5.00e-35	139.00
IUUC-Pyt-104517	Pyrenophora triticirepentis	50.00	5.00e-35	139.00
IUUC-Rno-105839	Rattus norvegicus	93.10	6.00e-78	282.00
IUUC-Sce-106349	Saccharomyces cerevisiae	48.53	3.00e-31	127.00
IUUC-Sha-106779	Sarcophilus harrisii	94.48	8.00e-71	258.00
IUUC-Sja-107722	Schizosaccharomyces japonicus	52.55	9.00e-34	135.00
IUUC-Spo-108027	Schizosaccharomyces pombe	48.91	1.00e-31	128.00
IUUC-Ssl-108493	Sclerotinia sclerotiorum	53.19	8.00e-34	135.00
IUUC-Smo-109381	Selaginella moellendorffii	45.26	1.00e-36	145.00
IUUC-Sit-110302	Setaria italica	52.82	3.00e-39	154.00
IUUC-Sly-111205	Solanum lycopersicum	48.59	2.00e-36	144.00
IUUC-Stu-112459	Solanum tuberosum	47.89	4.00e-36	143.00
IUUC-Sar-113406	Sorex araneus	67.86	3.00e-47	180.00
IUUC-Sbi-114210	Sorghum bicolor	51.41	2.00e-38	151.00
IUUC-Sre-114909	Sporisorium reilianum	50.36	5.00e-34	136.00
IUUC-Ssc-115259	Sus scrofa	92.36	5.00e-77	279.00
IUUC-Tgu-116732	Taeniopygia guttata	96.38	1.00e-68	251.00
IUUC-Tru-118526	Takifugu rubripes	89.13	6.00e-55	206.00
IUUC-Tni-120169	Tetraodon nigroviridis	86.01	9.00e-56	208.00
IUUC-Tca-121025	Theobroma cacao	53.24	2.00e-37	149.00
IUUC-Tre-121971	Trichoderma reesei	53.24	9.00e-37	145.00
IUUC-Tvi-122622	Trichoderma virens	52.90	2.00e-36	144.00
IUUC-Tae-123818	Triticum aestivum	50.71	1.00e-37	148.00
IUUC-Tur-126083	Triticum urartu	51.11	3.00e-36	143.00
IUUC-Tbe-128105	Tupaia belangeri	87.77	9.00e-70	257.00
IUUC-Ttr-128959	Tursiops truncatus	93.10	1.00e-78	284.00
IUUC-Uma-129419	Ustilago maydis	51.82	1.00e-34	138.00
IUUC-Vda-129776	Verticillium dahliae	50.00	1.00e-33	135.00
IUUC-Vpa-130575	Vicugna pacos	89.21	5.00e-65	241.00
IUUC-Vvi-130831	Vitis vinifera	53.24	3.00e-38	150.00
IUUC-Xtr-131975	Xenopus tropicalis	90.34	8.00e-77	278.00
IUUC-Xma-133222	Xiphophorus maculatus	95.14	1.00e-70	258.00
IUUC-Yli-134591	Yarrowia lipolytica	49.50	5.00e-27	112.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence