iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072699

UUCD1 version

UUC-OrA-00597

Ensembl Protein ID

ENSOANP00000012794.3

UniProt Accession

F7EF57; F7EF57_ORNAN

Protein Name

Uncharacterized protein

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000008046.3	ENSOANT00000012796.3	ENSOANP00000012794.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.00e-131	436.4	437	769

Active Site

Position(s)	Description	Evidence
738	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 437  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 524
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 525  GFTLPFYKQLLGKPITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 609
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 610  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKH-CTPDSNIVKWFWKAVELFDEERRARLLQFV 697
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 698  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 769
           **********************************************************************76 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MSNPGGRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYIG KSDSVTISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGACCCAAA CATCAAGTAC CATCCGGCGG CCCCGGTCGA TAAGAGGACT CCGCCGCCCC 60
CGACCCGCCA TCGTCCGGAG ACATGTCCAA CCCCGGGGGC AGGAGGAACG GGCCCGTCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

KEGG

oaa:100079802

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	95.24	0.00e+00	1469.00
IUUC-Apl-003513	Anas platyrhynchos	94.18	0.00e+00	1469.00
IUUC-Aca-005358	Anolis carolinensis	94.56	0.00e+00	1496.00
IUUC-Ame-011320	Astyanax mexicanus	88.27	0.00e+00	1402.00
IUUC-Bta-013399	Bos taurus	94.42	0.00e+00	1462.00
IUUC-Cja-019355	Callithrix jacchus	94.64	0.00e+00	1467.00
IUUC-Cpo-022200	Cavia porcellus	95.63	0.00e+00	1471.00
IUUC-Cho-024804	Choloepus hoffmanni	98.38	0.00e+00	639.00
IUUC-Cin-025126	Ciona intestinalis	64.33	0.00e+00	970.00
IUUC-Csv-026339	Ciona savignyi	63.17	0.00e+00	1001.00
IUUC-Dre-027650	Danio rerio	89.74	0.00e+00	1434.00
IUUC-Dno-029534	Dasypus novemcinctus	95.45	0.00e+00	1497.00
IUUC-Ete-032715	Echinops telfairi	90.69	0.00e+00	1375.00
IUUC-Eca-033580	Equus caballus	95.63	0.00e+00	1469.00
IUUC-Eeu-034945	Erinaceus europaeus	93.32	0.00e+00	1358.00
IUUC-Fal-037275	Ficedula albicollis	93.82	0.00e+00	1460.00
IUUC-Gga-041060	Gallus gallus	91.32	0.00e+00	1422.00
IUUC-Gac-041983	Gasterosteus aculeatus	88.43	0.00e+00	1401.00
IUUC-Hsa-046726	Homo sapiens	95.71	0.00e+00	1498.00
IUUC-Lch-050026	Latimeria chalumnae	92.73	0.00e+00	1466.00
IUUC-Loc-051760	Lepisosteus oculatus	89.09	0.00e+00	1390.00
IUUC-Laf-053753	Loxodonta africana	95.49	0.00e+00	1468.00
IUUC-Mcc-054815	Macaca mulatta	95.71	0.00e+00	1498.00
IUUC-Meu-056436	Macropus eugenii	73.64	0.00e+00	1092.00
IUUC-Mpo-057442	Magnaporthe poae	37.27	1.00e-143	503.00
IUUC-Mmr-060806	Microcebus murinus	95.36	0.00e+00	1467.00
IUUC-Mdo-062805	Monodelphis domestica	94.03	0.00e+00	1481.00
IUUC-Mmu-064034	Mus musculus	95.71	0.00e+00	1497.00
IUUC-Mpu-066762	Mustela putorius furo	95.24	0.00e+00	1468.00
IUUC-Mlu-066981	Myotis lucifugus	95.49	0.00e+00	1467.00
IUUC-Nle-069804	Nomascus leucogenys	95.70	0.00e+00	1492.00
IUUC-Opr-070591	Ochotona princeps	90.29	0.00e+00	1368.00
IUUC-Ont-072243	Oreochromis niloticus	89.56	0.00e+00	1426.00
IUUC-Ocu-074913	Oryctolagus cuniculus	95.71	0.00e+00	1500.00
IUUC-Ola-086597	Oryzias latipes	82.55	0.00e+00	1278.00
IUUC-Oga-089116	Otolemur garnettii	92.18	0.00e+00	1405.00
IUUC-Oar-089366	Ovis aries	94.17	0.00e+00	1463.00
IUUC-Ptr-091382	Pan troglodytes	95.71	0.00e+00	1498.00
IUUC-Psi-093298	Pelodiscus sinensis	93.77	0.00e+00	1454.00
IUUC-Pma-094354	Petromyzon marinus	72.16	0.00e+00	1127.00
IUUC-Pfo-096071	Poecilia formosa	90.22	0.00e+00	1425.00
IUUC-Pab-098682	Pongo abelii	95.71	0.00e+00	1499.00
IUUC-Pca-100516	Procavia capensis	89.53	0.00e+00	631.00
IUUC-Pva-102754	Pteropus vampyrus	94.41	0.00e+00	1430.00
IUUC-Rno-105600	Rattus norvegicus	95.29	0.00e+00	1269.00
IUUC-Sha-107144	Sarcophilus harrisii	94.45	0.00e+00	1342.00
IUUC-Spo-108171	Schizosaccharomyces pombe	39.43	4.00e-162	564.00
IUUC-Sar-113122	Sorex araneus	84.57	0.00e+00	1250.00
IUUC-Tgu-117112	Taeniopygia guttata	94.17	0.00e+00	1488.00
IUUC-Tru-118497	Takifugu rubripes	87.34	0.00e+00	1367.00
IUUC-Tni-120781	Tetraodon nigroviridis	87.59	0.00e+00	1180.00
IUUC-Tme-126897	Tuber melanosporum	38.37	2.00e-151	529.00
IUUC-Tbe-127371	Tupaia belangeri	84.83	0.00e+00	1199.00
IUUC-Ttr-129305	Tursiops truncatus	87.62	0.00e+00	1261.00
IUUC-Vpa-130591	Vicugna pacos	85.37	0.00e+00	1270.00
IUUC-Xtr-132979	Xenopus tropicalis	75.16	0.00e+00	1101.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence