iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115766

Ensembl Protein ID

ENSSSCP00000002538.2

UniProt Accession

F1S3K9; F1S3K9_PIG

Genbank Protein ID

ENSSSCP00000002538

Protein Name

Presenilin

Genbank Nucleotide ID

CU855510

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000002340.3	ENSSSCT00000002603.3	ENSSSCP00000002538.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.10e-08	35.2	273	311

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e+++++FP+l+ys+++v+L++++  +++a+ +  
   Q: 273  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRKVS 311
           89****************************999998876 PP

Organism

Sus scrofa

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DSRERHEHSI ERRRRGNSES LSNGGAQGNS 60
RQVVEQEEEE DEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFYTRK DGQLIYTPFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGGCTGGG ATTTCACATC GGAAACAAAA CAGCGGCTGC TGGGGAAGGG ACCTGGGCTG 60
CGAGAGGTGG CGGCTGCGAC GAGAAAGAGT AAGTGCGCGC TGGGGAGGTG GGGAGAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	33.11	2.00e-21	97.40
IUUC-Aml-001648	Ailuropoda melanoleuca	93.15	4.00e-165	573.00
IUUC-Atr-003039	Amborella trichopoda	32.96	4.00e-39	155.00
IUUC-Apl-003727	Anas platyrhynchos	81.36	3.00e-177	614.00
IUUC-Aca-004582	Anolis carolinensis	79.24	8.00e-179	619.00
IUUC-Aly-005455	Arabidopsis lyrata	31.29	3.00e-35	142.00
IUUC-Ath-006730	Arabidopsis thaliana	33.03	9.00e-34	137.00
IUUC-Ame-011500	Astyanax mexicanus	80.15	8.00e-148	516.00
IUUC-Bta-013026	Bos taurus	92.89	0.00e+00	725.00
IUUC-Bdi-014196	Brachypodium distachyon	32.13	2.00e-28	120.00
IUUC-Bol-015841	Brassica oleracea	37.01	2.00e-33	136.00
IUUC-Bra-017580	Brassica rapa	36.01	1.00e-30	127.00
IUUC-Cel-018553	Caenorhabditis elegans	52.96	2.00e-95	342.00
IUUC-Cja-019994	Callithrix jacchus	94.09	0.00e+00	660.00
IUUC-Cfa-020074	Canis familiaris	94.44	0.00e+00	732.00
IUUC-Cpo-022237	Cavia porcellus	90.91	0.00e+00	673.00
IUUC-Csa-023537	Chlorocebus sabaeus	93.16	0.00e+00	743.00
IUUC-Cho-024735	Choloepus hoffmanni	81.24	0.00e+00	659.00
IUUC-Cin-025780	Ciona intestinalis	61.90	4.00e-124	437.00
IUUC-Csv-025967	Ciona savignyi	62.62	3.00e-118	418.00
IUUC-Dre-028689	Danio rerio	78.34	8.00e-144	503.00
IUUC-Dno-029758	Dasypus novemcinctus	91.26	0.00e+00	716.00
IUUC-Dor-030609	Dipodomys ordii	70.94	6.00e-165	573.00
IUUC-Dme-031929	Drosophila melanogaster	56.04	2.00e-111	395.00
IUUC-Ete-032487	Echinops telfairi	80.00	3.00e-79	288.00
IUUC-Eeu-035134	Erinaceus europaeus	91.21	1.00e-141	495.00
IUUC-Fca-036243	Felis catus	95.94	0.00e+00	738.00
IUUC-Fal-036600	Ficedula albicollis	82.38	2.00e-178	618.00
IUUC-Gmo-038550	Gadus morhua	65.57	2.00e-113	402.00
IUUC-Gga-040993	Gallus gallus	81.74	1.00e-180	625.00
IUUC-Gac-042342	Gasterosteus aculeatus	68.91	1.00e-129	456.00
IUUC-Gma-043822	Glycine max	39.71	2.00e-25	109.00
IUUC-Ggo-044859	Gorilla gorilla	90.52	6.00e-157	546.00
IUUC-Hsa-046822	Homo sapiens	92.95	0.00e+00	742.00
IUUC-Hvu-047141	Hordeum vulgare	35.29	2.00e-25	109.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	92.86	5.00e-153	533.00
IUUC-Lch-049946	Latimeria chalumnae	70.09	3.00e-145	508.00
IUUC-Lpe-051132	Leersia perrieri	32.83	6.00e-30	124.00
IUUC-Laf-053979	Loxodonta africana	87.39	3.00e-175	607.00
IUUC-Mcc-055682	Macaca mulatta	92.95	0.00e+00	742.00
IUUC-Meu-056004	Macropus eugenii	75.89	3.00e-154	538.00
IUUC-Mtr-058392	Medicago truncatula	35.89	4.00e-31	128.00
IUUC-Mga-059466	Meleagris gallopavo	81.53	3.00e-180	624.00
IUUC-Mmr-061538	Microcebus murinus	75.64	5.00e-159	553.00
IUUC-Mdo-062122	Monodelphis domestica	87.26	0.00e+00	683.00
IUUC-Mmu-063176	Mus musculus	89.10	0.00e+00	689.00
IUUC-Mpu-065927	Mustela putorius furo	94.44	0.00e+00	721.00
IUUC-Mlu-067079	Myotis lucifugus	94.66	0.00e+00	762.00
IUUC-Nle-070180	Nomascus leucogenys	92.95	0.00e+00	742.00
IUUC-Opr-070847	Ochotona princeps	85.50	0.00e+00	640.00
IUUC-Ont-071846	Oreochromis niloticus	77.19	3.00e-147	514.00
IUUC-Oan-072783	Ornithorhynchus anatinus	83.13	1.00e-133	469.00
IUUC-Ocu-074527	Oryctolagus cuniculus	90.41	0.00e+00	724.00
IUUC-Oba-075256	Oryza barthii	34.25	2.00e-27	116.00
IUUC-Ogl-077097	Oryza glaberrima	33.59	3.00e-28	119.00
IUUC-Ogu-078570	Oryza glumaepatula	33.59	3.00e-28	119.00
IUUC-Oin-079244	Oryza indica	33.33	3.00e-28	119.00
IUUC-Olo-080484	Oryza longistaminata	36.07	4.00e-23	101.00
IUUC-Ome-081814	Oryza meridionalis	33.59	2.00e-28	119.00
IUUC-Oni-082057	Oryza nivara	33.33	3.00e-28	119.00
IUUC-Opu-084176	Oryza punctata	33.16	2.00e-28	119.00
IUUC-Oru-084618	Oryza rufipogon	33.59	3.00e-28	119.00
IUUC-Osa-085602	Oryza sativa	33.59	3.00e-28	119.00
IUUC-Olu-087811	Ostreococcus lucimarinus	37.82	7.00e-48	184.00
IUUC-Oar-090348	Ovis aries	94.02	0.00e+00	769.00
IUUC-Ptr-091060	Pan troglodytes	92.95	0.00e+00	742.00
IUUC-Pan-091855	Papio anubis	85.04	0.00e+00	650.00
IUUC-Psi-093505	Pelodiscus sinensis	81.53	1.00e-178	619.00
IUUC-Pfo-097396	Poecilia formosa	75.74	2.00e-152	531.00
IUUC-Pab-098591	Pongo abelii	91.88	0.00e+00	726.00
IUUC-Pop-099661	Populus trichocarpa	33.42	5.00e-33	134.00
IUUC-Pca-101029	Procavia capensis	86.35	0.00e+00	652.00
IUUC-Ppe-101495	Prunus persica	31.84	1.00e-37	150.00
IUUC-Pva-102244	Pteropus vampyrus	87.61	0.00e+00	679.00
IUUC-Rno-105861	Rattus norvegicus	88.72	0.00e+00	673.00
IUUC-Sha-107045	Sarcophilus harrisii	87.66	0.00e+00	679.00
IUUC-Smo-109325	Selaginella moellendorffii	35.44	1.00e-37	150.00
IUUC-Sit-110624	Setaria italica	34.06	7.00e-27	114.00
IUUC-Stu-112433	Solanum tuberosum	34.71	4.00e-33	135.00
IUUC-Sar-113169	Sorex araneus	87.82	6.00e-142	496.00
IUUC-Sbi-114305	Sorghum bicolor	33.44	1.00e-25	110.00
IUUC-Tgu-116469	Taeniopygia guttata	86.73	3.00e-138	484.00
IUUC-Tru-117732	Takifugu rubripes	77.08	6.00e-146	510.00
IUUC-Tsy-119624	Tarsius syrichta	82.94	0.00e+00	649.00
IUUC-Tni-119852	Tetraodon nigroviridis	71.90	2.00e-136	478.00
IUUC-Tca-121865	Theobroma cacao	33.42	4.00e-38	152.00
IUUC-Tae-125925	Triticum aestivum	35.28	2.00e-26	113.00
IUUC-Tur-126237	Triticum urartu	35.08	5.00e-26	111.00
IUUC-Tbe-128148	Tupaia belangeri	83.55	6.00e-165	573.00
IUUC-Ttr-128793	Tursiops truncatus	95.51	0.00e+00	726.00
IUUC-Vpa-130625	Vicugna pacos	78.80	7.00e-162	563.00
IUUC-Vvi-131312	Vitis vinifera	34.94	2.00e-35	142.00
IUUC-Xtr-131790	Xenopus tropicalis	77.92	6.00e-157	546.00
IUUC-Xma-133377	Xiphophorus maculatus	76.52	2.00e-150	525.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence