iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062365

UUCD1 version

UUC-MoD-00283

Ensembl Protein ID

ENSMODP00000017551.2

UniProt Accession

F6UQJ4; F6UQJ4_MONDO

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000014037.2	ENSMODT00000017877.2	ENSMODP00000017551.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.70e-45	149.7	145	180
UBD/Beta-Prp	8.00e-60	202.7	15	261

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt  v+cl+f +d + l+s++dD+++k+WDl+ g+
   Q: 145  GHTQAVRCLRFsPDgKWLASAADDHSVKLWDLTAGK 180
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w+v +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKGSGRLLATGGDDCRVNLWSVNKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 103
           6778888999989999************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D  v+lWdl  gk++ ++ g ht+
   Q: 104  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYKGHTQAVRCLRFSPDGKWLASAADDHSVKLWDLTAGKMMSEFLG-HTG 190
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
           +v  ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v+s+ f p++  l+sg +D s+r++  + 
   Q: 191  PVSVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSILFNPDGCCLYSGCQD-SLRVYGWEP 261
           ***********************************************************755.566654444 PP

Organism

Monodelphis domestica

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK GSGRLLATGG DDCRVNLWSV NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAACCC CTGTTGTTAC CAAGACAGCA TGGAAGCTAC GTGAGTCTCC TACGTATCTT 60
TTTCTCCTAC CATCTCTGCT TGTTATCTTA TTAGCCACCT GTTTCCCCCT AGAGAATGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007079--P:mitotic chromosome movement towards spindle pole
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	48.63	2.00e-85	311.00
IUUC-Aml-002187	Ailuropoda melanoleuca	80.92	0.00e+00	991.00
IUUC-Atr-002899	Amborella trichopoda	54.79	5.00e-102	365.00
IUUC-Apl-003305	Anas platyrhynchos	74.49	0.00e+00	971.00
IUUC-Aca-004635	Anolis carolinensis	77.22	0.00e+00	909.00
IUUC-Aly-005711	Arabidopsis lyrata	52.16	4.00e-101	362.00
IUUC-Ath-007606	Arabidopsis thaliana	52.16	3.00e-101	362.00
IUUC-Ame-010870	Astyanax mexicanus	51.23	3.00e-84	305.00
IUUC-Bta-012527	Bos taurus	85.84	0.00e+00	1082.00
IUUC-Bdi-014652	Brachypodium distachyon	53.85	5.00e-103	369.00
IUUC-Bol-015242	Brassica oleracea	49.84	1.00e-99	357.00
IUUC-Bra-017390	Brassica rapa	51.50	8.00e-100	358.00
IUUC-Cja-019706	Callithrix jacchus	85.43	0.00e+00	998.00
IUUC-Cfa-020139	Canis familiaris	74.42	0.00e+00	709.00
IUUC-Cpo-021710	Cavia porcellus	85.45	0.00e+00	1046.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	41.81	4.00e-68	253.00
IUUC-Csa-023546	Chlorocebus sabaeus	86.49	0.00e+00	962.00
IUUC-Cin-025156	Ciona intestinalis	40.66	7.00e-142	497.00
IUUC-Csv-025962	Ciona savignyi	49.32	2.00e-88	318.00
IUUC-Dre-028215	Danio rerio	60.06	0.00e+00	813.00
IUUC-Dno-029314	Dasypus novemcinctus	85.28	0.00e+00	1011.00
IUUC-Dor-030482	Dipodomys ordii	85.61	0.00e+00	1080.00
IUUC-Dme-032188	Drosophila melanogaster	40.13	9.00e-61	228.00
IUUC-Eca-034143	Equus caballus	84.77	0.00e+00	1058.00
IUUC-Fca-035924	Felis catus	86.21	0.00e+00	1038.00
IUUC-Fal-037387	Ficedula albicollis	76.18	0.00e+00	957.00
IUUC-Gmo-038692	Gadus morhua	64.22	1.00e-152	533.00
IUUC-Gga-040597	Gallus gallus	77.05	0.00e+00	1013.00
IUUC-Gac-042004	Gasterosteus aculeatus	59.46	0.00e+00	784.00
IUUC-Gma-044134	Glycine max	31.94	8.00e-108	384.00
IUUC-Ggo-044761	Gorilla gorilla	86.34	0.00e+00	995.00
IUUC-Hsa-045698	Homo sapiens	86.52	0.00e+00	1011.00
IUUC-Hvu-047649	Hordeum vulgare	53.85	3.00e-103	370.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	86.21	0.00e+00	1045.00
IUUC-Lch-049674	Latimeria chalumnae	66.37	0.00e+00	887.00
IUUC-Lpe-051554	Leersia perrieri	54.85	3.00e-105	376.00
IUUC-Loc-052623	Lepisosteus oculatus	65.22	0.00e+00	870.00
IUUC-Laf-054587	Loxodonta africana	87.12	0.00e+00	1072.00
IUUC-Mcc-055851	Macaca mulatta	86.34	0.00e+00	995.00
IUUC-Meu-056704	Macropus eugenii	91.95	0.00e+00	1201.00
IUUC-Mtr-058053	Medicago truncatula	52.82	7.00e-104	371.00
IUUC-Mga-059608	Meleagris gallopavo	75.46	0.00e+00	992.00
IUUC-Mmr-061154	Microcebus murinus	84.92	0.00e+00	1005.00
IUUC-Mmu-063754	Mus musculus	85.37	0.00e+00	1031.00
IUUC-Mac-064667	Musa acuminata	52.90	6.00e-100	357.00
IUUC-Mpu-066245	Mustela putorius furo	85.89	0.00e+00	1013.00
IUUC-Mlu-067692	Myotis lucifugus	86.66	0.00e+00	1041.00
IUUC-Nle-070051	Nomascus leucogenys	84.09	0.00e+00	973.00
IUUC-Opr-070855	Ochotona princeps	85.45	0.00e+00	1041.00
IUUC-Ont-071883	Oreochromis niloticus	57.87	0.00e+00	794.00
IUUC-Oan-073293	Ornithorhynchus anatinus	87.32	0.00e+00	1006.00
IUUC-Ocu-074644	Oryctolagus cuniculus	86.97	0.00e+00	1061.00
IUUC-Oba-075448	Oryza barthii	55.18	1.00e-105	377.00
IUUC-Obr-076385	Oryza brachyantha	54.18	1.00e-104	374.00
IUUC-Ogl-077427	Oryza glaberrima	55.18	5.00e-106	379.00
IUUC-Ogu-079022	Oryza glumaepatula	49.52	2.00e-97	350.00
IUUC-Oin-079811	Oryza indica	52.73	8.00e-103	368.00
IUUC-Olo-080245	Oryza longistaminata	52.73	9.00e-103	368.00
IUUC-Ome-081239	Oryza meridionalis	54.61	2.00e-102	367.00
IUUC-Oni-082640	Oryza nivara	55.18	1.00e-105	377.00
IUUC-Opu-083748	Oryza punctata	54.85	2.00e-105	376.00
IUUC-Oru-084609	Oryza rufipogon	55.18	1.00e-105	377.00
IUUC-Osa-086267	Oryza sativa	49.52	2.00e-97	350.00
IUUC-Ola-087483	Oryzias latipes	54.37	3.00e-171	595.00
IUUC-Oga-087964	Otolemur garnettii	85.91	0.00e+00	1064.00
IUUC-Oar-089483	Ovis aries	84.81	0.00e+00	1026.00
IUUC-Ptr-091387	Pan troglodytes	86.67	0.00e+00	1014.00
IUUC-Pan-092623	Papio anubis	86.34	0.00e+00	995.00
IUUC-Psi-093830	Pelodiscus sinensis	78.67	0.00e+00	1005.00
IUUC-Pma-094135	Petromyzon marinus	41.79	9.00e-31	126.00
IUUC-Ppa-095379	Physcomitrella patens	55.14	3.00e-97	350.00
IUUC-Pfo-096755	Poecilia formosa	57.55	0.00e+00	773.00
IUUC-Pab-097564	Pongo abelii	84.67	0.00e+00	867.00
IUUC-Pop-099149	Populus trichocarpa	52.82	2.00e-103	370.00
IUUC-Pca-100357	Procavia capensis	97.14	4.00e-123	435.00
IUUC-Ppe-101237	Prunus persica	52.82	3.00e-103	369.00
IUUC-Pva-102397	Pteropus vampyrus	81.94	0.00e+00	973.00
IUUC-Rno-105349	Rattus norvegicus	85.91	0.00e+00	1075.00
IUUC-Smo-109409	Selaginella moellendorffii	54.27	2.00e-100	359.00
IUUC-Sit-110360	Setaria italica	54.85	3.00e-105	376.00
IUUC-Sly-111307	Solanum lycopersicum	52.51	1.00e-97	351.00
IUUC-Stu-112053	Solanum tuberosum	52.19	1.00e-98	354.00
IUUC-Sar-112953	Sorex araneus	79.82	1.00e-105	377.00
IUUC-Sbi-114389	Sorghum bicolor	46.64	1.00e-92	334.00
IUUC-Ssc-115949	Sus scrofa	81.45	0.00e+00	755.00
IUUC-Tgu-117461	Taeniopygia guttata	75.64	0.00e+00	991.00
IUUC-Tru-117865	Takifugu rubripes	55.90	0.00e+00	744.00
IUUC-Tsy-119036	Tarsius syrichta	72.29	7.00e-71	261.00
IUUC-Tni-120903	Tetraodon nigroviridis	58.46	0.00e+00	733.00
IUUC-Tca-121185	Theobroma cacao	52.16	7.00e-101	362.00
IUUC-Tae-125263	Triticum aestivum	54.18	1.00e-103	371.00
IUUC-Tur-126181	Triticum urartu	47.96	2.00e-93	337.00
IUUC-Tbe-127518	Tupaia belangeri	70.29	8.00e-160	556.00
IUUC-Ttr-128172	Tursiops truncatus	83.92	0.00e+00	1023.00
IUUC-Vvi-131489	Vitis vinifera	53.16	1.00e-103	370.00
IUUC-Xtr-132915	Xenopus tropicalis	68.70	0.00e+00	897.00
IUUC-Xma-134133	Xiphophorus maculatus	57.06	0.00e+00	761.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence