iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-79	268.3	3761	4120

Active Site

Position(s)	Description	Evidence
4094	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3761 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 3843
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs.vseei..............lgetke 153
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+es++e+l+++++++    +                 + +e
   Q: 3844 ADVPLPLDLLPSFWKTLVGEPLDPdQDLQEADILTYNYvKKFESINDESELEALCAEIASQhL-ATDspegpkpccrftylTMTGEE 3929
           **************************************6666667889999999999999952.3334689********65555566 PP
   S: 154  eeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggy 239
           +eL+++G++ipV++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+ +++ e+el +cG +++++e lk++t+y+ g+
   Q: 3930 VELCSRGRHIPVAWENKDIYAAAIRSLRLRElQNMECVTAVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYVNLEFLKAHTMYQVGL 4016
           67*****************************9******************************************************* PP
   S: 240  tedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLPeY 313
           +e++++i+ Fw +le f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++      d+r+++++TC++++kLP+Y
   Q: 4017 METDQHIELFWGALETFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGPPDSRYIRVETCMFMIKLPQY 4103
           *******************************************99999999988888888889966667****************** PP
   S: 314  sskeilkekLlyAieet 330
           ss ei+ ekL++Ai+++
   Q: 4104 SSLEIMLEKLRCAIHYR 4120
           **************986 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MLPAPDSNPG SSSENKDADL GRCLTADGHY LYTTNSAGRG LSKLGSGLHG TLRGFVYCRN 60
EELEPGWVAY GSGHLLHRPV SFDNKPHSLF QVIDQNTLQV CQTVPMPASP LPVGSTMSTV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACTCACATG CATATCTATT TAAACCACTT GTGTCTGTTC TCTGAGCTGG GAAGTAGGCT 60
TCGTTTCTGG AACACACACG CTCAGATCCT TACCGTTCTC CTTCACCCCC ACAGGCTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	95.44	0.00e+00	7141.00
IUUC-Apl-004161	Anas platyrhynchos	91.70	0.00e+00	5141.00
IUUC-Aca-005341	Anolis carolinensis	87.80	0.00e+00	6578.00
IUUC-Ame-011574	Astyanax mexicanus	82.03	0.00e+00	4732.00
IUUC-Bta-012514	Bos taurus	94.32	0.00e+00	1882.00
IUUC-Cja-019148	Callithrix jacchus	95.79	0.00e+00	5241.00
IUUC-Cfa-020499	Canis familiaris	96.58	0.00e+00	7463.00
IUUC-Cpo-021894	Cavia porcellus	96.90	0.00e+00	2761.00
IUUC-Csa-023079	Chlorocebus sabaeus	96.92	0.00e+00	7486.00
IUUC-Cho-024415	Choloepus hoffmanni	92.23	0.00e+00	5045.00
IUUC-Dre-027452	Danio rerio	80.25	0.00e+00	4681.00
IUUC-Dno-029595	Dasypus novemcinctus	95.84	0.00e+00	7441.00
IUUC-Dor-030849	Dipodomys ordii	97.49	0.00e+00	1796.00
IUUC-Ete-032563	Echinops telfairi	88.45	0.00e+00	1595.00
IUUC-Eca-034202	Equus caballus	95.32	0.00e+00	7079.00
IUUC-Eeu-035175	Erinaceus europaeus	96.02	0.00e+00	1061.00
IUUC-Fca-036295	Felis catus	96.49	0.00e+00	7082.00
IUUC-Fal-037003	Ficedula albicollis	91.74	0.00e+00	6445.00
IUUC-Gmo-038579	Gadus morhua	84.74	0.00e+00	2869.00
IUUC-Gga-040961	Gallus gallus	91.91	0.00e+00	7219.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.41	0.00e+00	2898.00
IUUC-Ggo-045099	Gorilla gorilla	96.78	0.00e+00	6350.00
IUUC-Hsa-046331	Homo sapiens	96.71	0.00e+00	7528.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	95.54	0.00e+00	2144.00
IUUC-Lch-049923	Latimeria chalumnae	83.50	0.00e+00	2615.00
IUUC-Loc-052630	Lepisosteus oculatus	83.37	0.00e+00	4006.00
IUUC-Laf-053394	Loxodonta africana	96.00	0.00e+00	7526.00
IUUC-Mcc-055763	Macaca mulatta	97.00	0.00e+00	7490.00
IUUC-Meu-056039	Macropus eugenii	88.20	0.00e+00	5030.00
IUUC-Mga-059500	Meleagris gallopavo	90.43	0.00e+00	6889.00
IUUC-Mmr-060868	Microcebus murinus	93.30	0.00e+00	7215.00
IUUC-Mdo-062772	Monodelphis domestica	93.39	0.00e+00	7297.00
IUUC-Mmu-063606	Mus musculus	99.03	0.00e+00	7660.00
IUUC-Mpu-065860	Mustela putorius furo	93.54	0.00e+00	7006.00
IUUC-Mlu-067376	Myotis lucifugus	94.85	0.00e+00	7059.00
IUUC-Nle-069693	Nomascus leucogenys	94.35	0.00e+00	7296.00
IUUC-Opr-071065	Ochotona princeps	94.18	0.00e+00	1204.00
IUUC-Ont-072470	Oreochromis niloticus	80.06	0.00e+00	6232.00
IUUC-Oan-073693	Ornithorhynchus anatinus	91.56	0.00e+00	5178.00
IUUC-Ocu-074032	Oryctolagus cuniculus	95.58	0.00e+00	7469.00
IUUC-Ola-087433	Oryzias latipes	83.28	0.00e+00	1582.00
IUUC-Oga-088546	Otolemur garnettii	96.91	0.00e+00	6914.00
IUUC-Oar-089643	Ovis aries	90.64	0.00e+00	750.00
IUUC-Ptr-090504	Pan troglodytes	95.88	0.00e+00	7226.00
IUUC-Pan-092543	Papio anubis	96.85	0.00e+00	7478.00
IUUC-Psi-093952	Pelodiscus sinensis	88.47	0.00e+00	6773.00
IUUC-Pfo-096356	Poecilia formosa	80.91	0.00e+00	6420.00
IUUC-Pab-098240	Pongo abelii	96.78	0.00e+00	7473.00
IUUC-Pca-100994	Procavia capensis	96.92	0.00e+00	2984.00
IUUC-Pva-102263	Pteropus vampyrus	94.39	0.00e+00	7043.00
IUUC-Sha-106944	Sarcophilus harrisii	91.44	0.00e+00	7002.00
IUUC-Sar-113556	Sorex araneus	81.27	0.00e+00	959.00
IUUC-Ssc-116187	Sus scrofa	96.37	0.00e+00	5102.00
IUUC-Tgu-116655	Taeniopygia guttata	91.49	0.00e+00	5098.00
IUUC-Tru-118093	Takifugu rubripes	83.49	0.00e+00	3007.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.10	0.00e+00	1605.00
IUUC-Tbe-127962	Tupaia belangeri	91.40	0.00e+00	1201.00
IUUC-Ttr-128819	Tursiops truncatus	90.86	0.00e+00	2808.00
IUUC-Vpa-130482	Vicugna pacos	93.58	0.00e+00	4420.00
IUUC-Xtr-132222	Xenopus tropicalis	85.40	0.00e+00	6536.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence