iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000001641.1	ENSLACT00000001851.1	ENSLACP00000001838.1
ENSLACG00000001641.1	ENSLACT00000001852.1	ENSLACP00000001839.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.60e-82	275.4	25	737

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg...........ellkslqklfeel.......w.... 61
           +Gl+NlgNtCY+NSvLQ+L+  p ++  +++      kkkek++ e++++++            el+++l++l+ ++       +    
   Q: 25   VGLSNLGNTCYLNSVLQVLYYYPGFKAGMKHlfniisKKKEKFKSEEDQKDERetspedmpasyELVCNLNSLIVSIeklqisyLknpe 113
           6**********************************998888888877766655788888999998888888888888444433323333 PP
   S: 62   .kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.................... 129
            ++ + a++pr+ll++l++++++++gy q+DaqE+l+++l  ++e ++k k+++k+   e ++ +++++                    
   Q: 114  kYTGELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGYIQEVCQKLKEEEKNAVVEGESAQSNNIagneingraeqpstvdsepe 202
           355555*****************************************775555555555555444444488899999999999999999 PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 203  nkseieeqnepsaslpeekmrkrgtgkrssdteagnakkkskvikdqkvaleaktcarskrkpsgdgsdspadsdikicvensiarplq 291
           99*************************************************************************************** PP
   S: 130  .................................................................aeekkkkknk.........slisd 144
                                                                            +++k++k  +         +l+++
   Q: 292  kksrlglgffkssgkqpsilskfcslgklttslghkgqtkklrqtyepyssrspvnfgrgrflnlKKQKQNKT-PswltelnelELMER 379
           **************************************************************98633333333.2477888888***** PP
   S: 145  lFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..............slqdcLesftkeeelegenkyycekckkkqeaek 219
           lFqgql  +++clec+  ++r+e+f+d+s+pv+++e ++ e              +l++++++f++ e++ ge+ky+ce+c++++eae+
   Q: 380  LFQGQLVLRTRCLECECFTERREDFQDISVPVQENEPSEVEdgskispepkierkTLRWAISQFASVERIVGEDKYFCESCHHYTEAER 468
           ************************************88888************************************************ PP
   S: 220  klklkklPevLilhLkRf.....sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn. 301
           +l ++k+P+v+++hLk+f     +f+++++  +k+n+ + +pl+L+l ++ t+++     +++YeL+a v+HsG ++ssGHY+ayvk  
   Q: 469  SLLFDKMPDVITIHLKCFaanssEFDCYGGL-SKVNTPLLTPLKLSLGEWSTQQT-----SDRYELFAAVMHSGiTISSGHYTAYVKIt 551
           ******************9999999999555.6********************66.....689************************** PP
   S: 302  ......................................................................................... 301
                                                                                                    
   Q: 552  dlshleglseisaldhkdddiktepvneqgakalivedyddgevsfkvngsgamvvgskvsnkknaegvgllggqksitnvelsnskts 640
           ***************************************************************************************** PP
   S: 302  .......................................................ekgkWllfdDskVtevkeeevleetg......st 329
                                                                   +gkW+lfdDs+V++++e++ l + +      +t
   Q: 641  pceksghialengqsdfapenssedvkecsnqngdvcnggisksqalsaswslreYEGKWILFDDSEVKTIEEKDLLISLSpntsstTT 729
           ********************999999999999999999999888888888887777999******************9877999***** PP
   S: 330  aYvlfYkr 337
           +Y+lfYk+
   Q: 730  PYLLFYKK 737
           ******98 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

DQAVPTVQSI SPDVCEKREN LLPFVGLSNL GNTCYLNSVL QVLYYYPGFK AGMKHLFNII 60
SKKKEKFKSE EDQKDERETS PEDMPASYEL VCNLNSLIVS IEKLQISYLK NPEKYTGELA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNCCTT ACCTGGCTTG GGTAACCCTG CCAGGAGCTT ACGCTCCCGC CAGCATAGCT 60
CTCAGGATCA TTGGGGCACG CAAGCCCTTC CACCACATCA AGTTGGCAGT CCTTTAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001939	Ailuropoda melanoleuca	58.46	0.00e+00	728.00
IUUC-Apl-004204	Anas platyrhynchos	59.66	0.00e+00	728.00
IUUC-Aca-004637	Anolis carolinensis	56.23	0.00e+00	704.00
IUUC-Ame-011718	Astyanax mexicanus	48.29	1.00e-163	570.00
IUUC-Bta-012552	Bos taurus	57.09	0.00e+00	718.00
IUUC-Cja-019588	Callithrix jacchus	57.11	0.00e+00	734.00
IUUC-Cfa-020211	Canis familiaris	58.07	0.00e+00	733.00
IUUC-Cpo-021551	Cavia porcellus	57.01	0.00e+00	700.00
IUUC-Csa-024186	Chlorocebus sabaeus	57.35	0.00e+00	740.00
IUUC-Cho-024739	Choloepus hoffmanni	52.48	4.00e-91	328.00
IUUC-Dre-028184	Danio rerio	47.60	2.00e-169	589.00
IUUC-Dno-029669	Dasypus novemcinctus	56.60	0.00e+00	717.00
IUUC-Dor-030168	Dipodomys ordii	55.79	0.00e+00	633.00
IUUC-Dme-031732	Drosophila melanogaster	31.79	1.00e-19	92.40
IUUC-Ete-032825	Echinops telfairi	53.81	2.00e-142	499.00
IUUC-Eca-033595	Equus caballus	57.69	0.00e+00	723.00
IUUC-Eeu-034877	Erinaceus europaeus	57.83	5.00e-93	335.00
IUUC-Fca-035381	Felis catus	58.61	3.00e-149	521.00
IUUC-Fal-037592	Ficedula albicollis	57.79	0.00e+00	694.00
IUUC-Gmo-039680	Gadus morhua	45.42	9.00e-154	536.00
IUUC-Gga-041196	Gallus gallus	59.76	0.00e+00	734.00
IUUC-Gac-042292	Gasterosteus aculeatus	48.51	4.00e-137	481.00
IUUC-Ggo-044671	Gorilla gorilla	57.52	0.00e+00	736.00
IUUC-Hsa-047020	Homo sapiens	57.22	0.00e+00	736.00
IUUC-Itr-048800	Ictidomys tridecemlineatus	51.95	4.00e-176	611.00
IUUC-Loc-052338	Lepisosteus oculatus	52.21	0.00e+00	677.00
IUUC-Laf-053707	Loxodonta africana	57.61	0.00e+00	729.00
IUUC-Mcc-055885	Macaca mulatta	57.63	0.00e+00	737.00
IUUC-Meu-056573	Macropus eugenii	53.95	8.00e-177	613.00
IUUC-Mga-059346	Meleagris gallopavo	59.00	0.00e+00	748.00
IUUC-Mmr-061612	Microcebus murinus	57.77	0.00e+00	723.00
IUUC-Mdo-062887	Monodelphis domestica	58.03	0.00e+00	699.00
IUUC-Mmu-064044	Mus musculus	57.33	0.00e+00	711.00
IUUC-Mpu-066847	Mustela putorius furo	58.93	0.00e+00	733.00
IUUC-Mlu-067684	Myotis lucifugus	58.65	0.00e+00	723.00
IUUC-Nle-070057	Nomascus leucogenys	57.48	0.00e+00	742.00
IUUC-Opr-070463	Ochotona princeps	53.61	1.00e-153	536.00
IUUC-Ont-071975	Oreochromis niloticus	45.32	3.00e-149	522.00
IUUC-Ocu-074840	Oryctolagus cuniculus	57.03	0.00e+00	727.00
IUUC-Ola-087088	Oryzias latipes	45.12	9.00e-163	567.00
IUUC-Oga-088472	Otolemur garnettii	59.33	0.00e+00	720.00
IUUC-Oar-089498	Ovis aries	56.88	0.00e+00	721.00
IUUC-Ptr-091395	Pan troglodytes	57.35	0.00e+00	737.00
IUUC-Pan-092462	Papio anubis	57.76	0.00e+00	736.00
IUUC-Psi-093583	Pelodiscus sinensis	58.47	0.00e+00	695.00
IUUC-Pma-094644	Petromyzon marinus	43.33	5.00e-26	110.00
IUUC-Pfo-096314	Poecilia formosa	46.33	3.00e-149	522.00
IUUC-Pab-098568	Pongo abelii	58.03	0.00e+00	739.00
IUUC-Pca-100948	Procavia capensis	58.73	2.00e-93	336.00
IUUC-Pva-102853	Pteropus vampyrus	58.92	0.00e+00	734.00
IUUC-Rno-105573	Rattus norvegicus	56.77	0.00e+00	714.00
IUUC-Sha-107495	Sarcophilus harrisii	55.33	1.00e-175	609.00
IUUC-Sar-113545	Sorex araneus	51.07	2.00e-162	566.00
IUUC-Ssc-115962	Sus scrofa	58.94	0.00e+00	744.00
IUUC-Tgu-116731	Taeniopygia guttata	58.08	0.00e+00	693.00
IUUC-Tru-117893	Takifugu rubripes	45.13	1.00e-142	500.00
IUUC-Tsy-119644	Tarsius syrichta	62.03	3.00e-91	329.00
IUUC-Tni-119819	Tetraodon nigroviridis	46.81	4.00e-154	538.00
IUUC-Tbe-127272	Tupaia belangeri	55.11	0.00e+00	666.00
IUUC-Ttr-128404	Tursiops truncatus	58.65	0.00e+00	733.00
IUUC-Vpa-130205	Vicugna pacos	58.13	0.00e+00	724.00
IUUC-Xtr-132613	Xenopus tropicalis	52.59	0.00e+00	684.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence