• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046053
Ensembl Protein ID ENSP00000298838.6
UniProt Accession Q9UKS6; A6NH84; Q9H331; Q9NWV9; PACN3_HUMAN
Genbank Protein ID AAF04472.1; AAG31023.1; AAK29207.1; AAH07914.1; AAH11889.1; BAA91267.1
Protein Name Protein kinase C and casein kinase substrate in neurons protein 3; SH3 domain-containing protein 6511
Genbank Nucleotide ID AF130979; AF149825; AF242530; AC090589; BC011889; AK000577
Gene Name PACSIN3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000165912.15 ENST00000298838.10 ENSP00000298838.6
ENSG00000165912.15 ENST00000532457.5 ENSP00000431948.1
ENSG00000165912.15 ENST00000533686.5 ENSP00000433962.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 4.00e-13 50.8 367 421
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +v++lydy +q+ deL++++G+ +l +  ee ++gW++g+   +g+ Gl P+n+ve 
   Q: 367  RVRALYDYAGQEADELSFRAGEELLKM-SEEDEQGWCQGQ-LQSGRIGLYPANYVEC 421
           689********************9999.999********7.99************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).
 Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).
Protein Sequence
(Fasta)
MAPEEDAGGE ALGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE KAYAQQLADW 60
ARKWRGTVEK GPQYGTLEKA WHAFFTAAER LSALHLEVRE KLQGQDSERV RAWQRGAFHR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046053|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCTCCGGGA GGCCGCGGCG CGGGCCCAGG AGCGGCAGGA CTCGGGCCGG AGCGTGGCCG 60
GACCCCCACC CGCCGAGGGG CCCAGGGAGG ACGCGGTGAG TGCCCTGGAG GGGACGCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046053|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR028523--PACSIN3
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019855--F:calcium channel inhibitor activity
GO:0008092--F:cytoskeletal protein binding
GO:0008289--F:lipid binding
GO:0006897--P:endocytosis
GO:0051926--P:negative regulation of calcium ion transport
GO:0045806--P:negative regulation of endocytosis
GO:0097320--P:plasma membrane tubulation
GO:0051044--P:positive regulation of membrane protein ectodomain proteolysis
GO:0030100--P:regulation of endocytosis
KEGG hsa:29763
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001906 Ailuropoda melanoleuca 96.10 0.00e+00 655.00
IUUC-Apl-003211 Anas platyrhynchos 64.85 0.00e+00 626.00
IUUC-Aca-004256 Anolis carolinensis 64.62 3.00e-178 618.00
IUUC-Ame-011049 Astyanax mexicanus 60.59 1.00e-153 536.00
IUUC-Bta-013322 Bos taurus 92.60 0.00e+00 774.00
IUUC-Cja-018907 Callithrix jacchus 98.58 0.00e+00 822.00
IUUC-Cfa-021126 Canis familiaris 96.46 0.00e+00 805.00
IUUC-Cpo-021491 Cavia porcellus 93.87 0.00e+00 795.00
IUUC-Csa-023107 Chlorocebus sabaeus 100.00 0.00e+00 828.00
IUUC-Dre-027933 Danio rerio 60.36 6.00e-147 514.00
IUUC-Dno-029002 Dasypus novemcinctus 95.52 0.00e+00 771.00
IUUC-Eca-033824 Equus caballus 95.52 0.00e+00 801.00
IUUC-Eeu-035122 Erinaceus europaeus 86.40 5.00e-174 603.00
IUUC-Fca-036420 Felis catus 96.46 0.00e+00 817.00
IUUC-Fal-037277 Ficedula albicollis 64.77 0.00e+00 633.00
IUUC-Gga-040941 Gallus gallus 64.99 1.00e-180 625.00
IUUC-Gac-041374 Gasterosteus aculeatus 62.44 2.00e-138 486.00
IUUC-Ggo-045211 Gorilla gorilla 99.53 0.00e+00 825.00
IUUC-Itr-047939 Ictidomys tridecemlineatus 96.23 0.00e+00 810.00
IUUC-Loc-052808 Lepisosteus oculatus 62.64 7.00e-158 550.00
IUUC-Laf-054211 Loxodonta africana 94.81 0.00e+00 764.00
IUUC-Mcc-055044 Macaca mulatta 100.00 0.00e+00 828.00
IUUC-Mga-059216 Meleagris gallopavo 64.92 0.00e+00 627.00
IUUC-Mmr-061172 Microcebus murinus 99.06 0.00e+00 831.00
IUUC-Mdo-062600 Monodelphis domestica 88.44 0.00e+00 771.00
IUUC-Mmu-063218 Mus musculus 94.34 0.00e+00 796.00
IUUC-Mpu-066819 Mustela putorius furo 96.70 0.00e+00 660.00
IUUC-Mlu-067597 Myotis lucifugus 92.34 0.00e+00 792.00
IUUC-Nle-069195 Nomascus leucogenys 99.29 0.00e+00 823.00
IUUC-Opr-071050 Ochotona princeps 95.76 0.00e+00 784.00
IUUC-Ont-071612 Oreochromis niloticus 55.25 3.00e-141 494.00
IUUC-Oan-073256 Ornithorhynchus anatinus 88.73 0.00e+00 746.00
IUUC-Ocu-074653 Oryctolagus cuniculus 96.70 0.00e+00 781.00
IUUC-Oga-089040 Otolemur garnettii 96.46 0.00e+00 819.00
IUUC-Oar-089918 Ovis aries 96.10 0.00e+00 790.00
IUUC-Ptr-091307 Pan troglodytes 100.00 0.00e+00 828.00
IUUC-Pan-092512 Papio anubis 100.00 0.00e+00 828.00
IUUC-Pfo-096881 Poecilia formosa 61.35 4.00e-154 537.00
IUUC-Pab-098620 Pongo abelii 100.00 0.00e+00 828.00
IUUC-Pva-102464 Pteropus vampyrus 92.69 0.00e+00 776.00
IUUC-Rno-106091 Rattus norvegicus 93.87 0.00e+00 792.00
IUUC-Sha-107474 Sarcophilus harrisii 89.39 0.00e+00 769.00
IUUC-Ssc-116128 Sus scrofa 95.75 0.00e+00 809.00
IUUC-Tgu-117511 Taeniopygia guttata 62.11 2.00e-176 612.00
IUUC-Tru-118005 Takifugu rubripes 61.09 7.00e-142 497.00
IUUC-Tni-119851 Tetraodon nigroviridis 65.46 7.00e-141 493.00
IUUC-Ttr-129313 Tursiops truncatus 95.75 0.00e+00 813.00
IUUC-Vpa-130760 Vicugna pacos 97.27 3.00e-101 362.00
IUUC-Xtr-132697 Xenopus tropicalis 58.10 4.00e-141 494.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved