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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046784
UUCD1 version UUC-HoS-00875
Ensembl Protein ID ENSP00000265097.4
UniProt Accession Q96J01; Q6NZ53; THOC3_HUMAN
Genbank Protein ID AAH06849.1; AAH66325.1; AAH68499.1
Protein Name THO complex subunit 3; TEX1 homolog; hTREX45
Genbank Nucleotide ID AC138965; BC066325; BC068499
Gene Name THOC3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000051596.9 ENST00000432305.6 ENSP00000394166.2
ENSG00000051596.9 ENST00000515016.1 ENSP00000425781.1
ENSG00000051596.9 ENST00000265097.8 ENSP00000265097.4
ENSG00000051596.9 ENST00000505969.1 ENSP00000424967.1
ENSG00000051596.9 ENST00000514861.5 ENSP00000425039.1
ENSG00000051596.9 ENST00000513482.1 ENSP00000422243.1
ENSG00000051596.9 ENST00000511062.5 ENSP00000427029.1
ENSG00000051596.9 ENST00000513006.1 ENSP00000421082.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.50e-29 102.4 97 135
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvll 36
           gH dsv  l++  s+ +l+v++s+D+ti++WD+rt +++
   Q: 97   GHGDSVDQLCWhpSNpDLFVTASGDKTIRIWDVRTTKCI 135
           8***********8778*******************9997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
 Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Protein Sequence
(Fasta)
MAVPAAAMGP SALGQSGPGS MAPWCSVSSG PSRYVLGMQE LFRGHSKTRE FLAHSAKVHS 60
VAWSCDGRRL ASGSFDKTAS VFLLEKDRLV KENNYRGHGD SVDQLCWHPS NPDLFVTASG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046784|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
GTAGGAGTCA CCTGTGGTGA GCTGGAGGTT GGAGCCTGTA GATGGCGTGG CTCTGTGGCT 60
CACTTCCTGT GGTTGTGGCA GTGACAGCGA TGGAGACTGC AGCTCGACAG GAATGGTAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046784|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0509--mRNA transport
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR013979--TIF_beta_prop-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF08662--eIF2A
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0000445--C:THO complex part of transcription export complex
GO:0000346--C:transcription export complex
GO:0003723--F:RNA binding
GO:0031124--P:mRNA 3'-end processing
GO:0006406--P:mRNA export from nucleus
GO:0006405--P:RNA export from nucleus
GO:0008380--P:RNA splicing
GO:0006369--P:termination of RNA polymerase II transcription
GO:0046784--P:viral mRNA export from host cell nucleus
KEGG hsa:84321
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000099 Aegilops tauschii 46.56 5.00e-84 304.00
IUUC-Aml-001264 Ailuropoda melanoleuca 99.13 0.00e+00 709.00
IUUC-Atr-003050 Amborella trichopoda 50.99 2.00e-91 328.00
IUUC-Apl-003426 Anas platyrhynchos 84.59 3.00e-129 454.00
IUUC-Aca-004931 Anolis carolinensis 94.14 2.00e-124 437.00
IUUC-Aly-006237 Arabidopsis lyrata 49.01 3.00e-90 325.00
IUUC-Ath-007581 Arabidopsis thaliana 49.34 1.00e-90 326.00
IUUC-Acl-008253 Aspergillus clavatus 27.89 9.00e-38 150.00
IUUC-Afl-008519 Aspergillus flavus 31.01 4.00e-40 158.00
IUUC-Afu-008886 Aspergillus fumigatus 26.29 3.00e-35 142.00
IUUC-Ani-009275 Aspergillus nidulans 29.71 6.00e-40 158.00
IUUC-Ang-009862 Aspergillus niger 29.23 8.00e-39 154.00
IUUC-Ate-010247 Aspergillus terreus 27.78 4.00e-37 149.00
IUUC-Ame-010828 Astyanax mexicanus 92.50 8.00e-180 622.00
IUUC-Bgr-012163 Blumeria graminis 29.96 3.00e-34 138.00
IUUC-Bta-013514 Bos taurus 86.32 2.00e-173 601.00
IUUC-Bci-013639 Botrytis cinerea 30.45 3.00e-43 168.00
IUUC-Bdi-015049 Brachypodium distachyon 47.25 3.00e-83 301.00
IUUC-Bol-015401 Brassica oleracea 50.49 2.00e-89 322.00
IUUC-Bra-017867 Brassica rapa 50.16 6.00e-89 320.00
IUUC-Cel-018699 Caenorhabditis elegans 33.98 1.00e-45 176.00
IUUC-Cja-019591 Callithrix jacchus 98.58 0.00e+00 723.00
IUUC-Cfa-020692 Canis familiaris 99.15 0.00e+00 726.00
IUUC-Cpo-022135 Cavia porcellus 85.80 1.00e-178 618.00
IUUC-Cre-022572 Chlamydomonas reinhardtii 34.47 7.00e-44 171.00
IUUC-Csa-023408 Chlorocebus sabaeus 99.72 0.00e+00 729.00
IUUC-Cho-024349 Choloepus hoffmanni 96.65 5.00e-119 419.00
IUUC-Cin-025418 Ciona intestinalis 71.01 1.00e-54 204.00
IUUC-Csv-026130 Ciona savignyi 66.25 9.00e-129 452.00
IUUC-Cgl-026744 Colletotrichum gloeosporioides 30.85 8.00e-44 170.00
IUUC-Dre-028634 Danio rerio 91.25 4.00e-179 620.00
IUUC-Dno-029449 Dasypus novemcinctus 98.58 0.00e+00 721.00
IUUC-Dor-030301 Dipodomys ordii 78.10 1.00e-120 425.00
IUUC-Dse-031341 Dothistroma septosporum 27.72 1.00e-31 130.00
IUUC-Dme-031674 Drosophila melanogaster 63.55 9.00e-123 432.00
IUUC-Ete-033136 Echinops telfairi 96.14 0.00e+00 679.00
IUUC-Eca-034432 Equus caballus 90.88 0.00e+00 663.00
IUUC-Fca-035694 Felis catus 99.15 0.00e+00 726.00
IUUC-Fal-037328 Ficedula albicollis 95.94 0.00e+00 642.00
IUUC-Fox-037894 Fusarium oxysporum 32.13 3.00e-43 169.00
IUUC-Fso-038266 Fusarium solani 29.33 5.00e-40 158.00
IUUC-Gmo-039617 Gadus morhua 90.94 2.00e-179 621.00
IUUC-Ggr-039819 Gaeumannomyces graminis 28.53 5.00e-38 151.00
IUUC-Gga-041164 Gallus gallus 95.27 0.00e+00 632.00
IUUC-Gac-042407 Gasterosteus aculeatus 91.88 0.00e+00 626.00
IUUC-Gma-043663 Glycine max 50.00 3.00e-91 328.00
IUUC-Ggo-044989 Gorilla gorilla 99.43 0.00e+00 728.00
IUUC-Hvu-047633 Hordeum vulgare 46.51 7.00e-58 216.00
IUUC-Itr-048184 Ictidomys tridecemlineatus 77.62 1.00e-153 535.00
IUUC-Kpa-049182 Komagataella pastoris 26.53 1.00e-16 80.50
IUUC-Lch-049894 Latimeria chalumnae 95.94 0.00e+00 641.00
IUUC-Lpe-051061 Leersia perrieri 40.85 6.00e-63 234.00
IUUC-Loc-052424 Lepisosteus oculatus 93.75 0.00e+00 634.00
IUUC-Lma-053127 Leptosphaeria maculans 33.22 2.00e-47 184.00
IUUC-Laf-053396 Loxodonta africana 99.09 0.00e+00 686.00
IUUC-Mcc-055517 Macaca mulatta 99.72 0.00e+00 729.00
IUUC-Meu-056034 Macropus eugenii 98.13 0.00e+00 658.00
IUUC-Mor-057011 Magnaporthe oryzae 26.39 2.00e-26 113.00
IUUC-Mpo-057490 Magnaporthe poae 28.53 3.00e-38 152.00
IUUC-Mtr-057927 Medicago truncatula 49.21 3.00e-91 328.00
IUUC-Mla-058945 Melampsora laricipopulina 34.24 3.00e-46 178.00
IUUC-Mga-060155 Meleagris gallopavo 95.22 8.00e-142 496.00
IUUC-Mvi-060344 Microbotryum violaceum 37.01 2.00e-54 206.00
IUUC-Mmr-060834 Microcebus murinus 98.58 0.00e+00 722.00
IUUC-Mdo-062587 Monodelphis domestica 98.43 0.00e+00 654.00
IUUC-Mmu-063395 Mus musculus 98.86 0.00e+00 723.00
IUUC-Mac-064579 Musa acuminata 49.01 3.00e-90 325.00
IUUC-Mpu-066688 Mustela putorius furo 96.72 6.00e-175 606.00
IUUC-Mlu-067299 Myotis lucifugus 98.86 0.00e+00 721.00
IUUC-Nfi-068562 Neosartorya fischeri 28.07 8.00e-37 147.00
IUUC-Ncr-068654 Neurospora crassa 28.72 1.00e-34 140.00
IUUC-Nle-069736 Nomascus leucogenys 98.86 0.00e+00 720.00
IUUC-Ont-071763 Oreochromis niloticus 92.50 0.00e+00 627.00
IUUC-Ocu-074909 Oryctolagus cuniculus 98.58 0.00e+00 696.00
IUUC-Oba-075902 Oryza barthii 41.18 2.00e-63 236.00
IUUC-Obr-076613 Oryza brachyantha 47.71 2.00e-82 298.00
IUUC-Ogl-077009 Oryza glaberrima 47.39 2.00e-81 295.00
IUUC-Ogu-078344 Oryza glumaepatula 41.18 2.00e-63 236.00
IUUC-Oin-079773 Oryza indica 47.39 2.00e-81 295.00
IUUC-Olo-080474 Oryza longistaminata 43.88 2.00e-45 175.00
IUUC-Ome-081837 Oryza meridionalis 43.48 6.00e-32 129.00
IUUC-Oni-082263 Oryza nivara 41.18 2.00e-63 236.00
IUUC-Opu-083813 Oryza punctata 47.39 3.00e-81 295.00
IUUC-Oru-084610 Oryza rufipogon 41.18 1.00e-63 236.00
IUUC-Osa-085415 Oryza sativa 47.39 2.00e-81 296.00
IUUC-Ola-086659 Oryzias latipes 92.81 0.00e+00 628.00
IUUC-Olu-087649 Ostreococcus lucimarinus 37.76 2.00e-56 212.00
IUUC-Oga-087923 Otolemur garnettii 99.15 0.00e+00 725.00
IUUC-Oar-089688 Ovis aries 95.73 0.00e+00 704.00
IUUC-Ptr-091628 Pan troglodytes 100.00 0.00e+00 731.00
IUUC-Pan-092586 Papio anubis 98.59 0.00e+00 722.00
IUUC-Psi-093701 Pelodiscus sinensis 94.12 5.00e-115 406.00
IUUC-Pma-094465 Petromyzon marinus 86.98 7.00e-171 592.00
IUUC-Pno-094767 Phaeosphaeria nodorum 33.70 4.00e-47 182.00
IUUC-Ppa-095195 Physcomitrella patens 52.31 2.00e-98 352.00
IUUC-Pfo-097383 Poecilia formosa 85.80 4.00e-180 624.00
IUUC-Pab-098669 Pongo abelii 99.72 0.00e+00 729.00
IUUC-Pop-099409 Populus trichocarpa 50.66 8.00e-92 330.00
IUUC-Pca-100769 Procavia capensis 86.89 2.00e-177 614.00
IUUC-Ppe-101321 Prunus persica 50.33 2.00e-91 328.00
IUUC-Pva-102759 Pteropus vampyrus 98.29 0.00e+00 720.00
IUUC-Pgr-103535 Puccinia graminis 35.29 2.00e-52 199.00
IUUC-Ptt-103820 Puccinia triticina 35.29 6.00e-52 197.00
IUUC-Pte-104271 Pyrenophora teres 31.77 4.00e-43 168.00
IUUC-Pyt-104500 Pyrenophora triticirepentis 31.30 3.00e-37 149.00
IUUC-Rno-106126 Rattus norvegicus 98.86 0.00e+00 723.00
IUUC-Sha-107146 Sarcophilus harrisii 93.57 0.00e+00 649.00
IUUC-Sja-107865 Schizosaccharomyces japonicus 37.17 7.00e-53 200.00
IUUC-Spo-108324 Schizosaccharomyces pombe 41.15 3.00e-60 225.00
IUUC-Smo-108990 Selaginella moellendorffii 51.29 2.00e-92 332.00
IUUC-Sit-110773 Setaria italica 48.84 3.00e-82 298.00
IUUC-Sly-111619 Solanum lycopersicum 50.99 4.00e-93 334.00
IUUC-Stu-112241 Solanum tuberosum 51.32 1.00e-93 335.00
IUUC-Sbi-114842 Sorghum bicolor 49.83 2.00e-83 302.00
IUUC-Sre-115070 Sporisorium reilianum 32.73 2.00e-48 186.00
IUUC-Ssc-115581 Sus scrofa 98.86 0.00e+00 725.00
IUUC-Tgu-117354 Taeniopygia guttata 94.57 5.00e-178 616.00
IUUC-Tru-117745 Takifugu rubripes 90.62 4.00e-178 617.00
IUUC-Tni-120050 Tetraodon nigroviridis 89.69 7.00e-176 609.00
IUUC-Tca-121279 Theobroma cacao 51.32 2.00e-91 328.00
IUUC-Tre-121952 Trichoderma reesei 31.07 1.00e-44 173.00
IUUC-Tvi-122581 Trichoderma virens 31.23 2.00e-45 176.00
IUUC-Tae-123910 Triticum aestivum 48.97 4.00e-84 304.00
IUUC-Tur-126279 Triticum urartu 46.86 8.00e-83 300.00
IUUC-Tme-127000 Tuber melanosporum 30.47 2.00e-38 152.00
IUUC-Ttr-128405 Tursiops truncatus 100.00 1.00e-157 548.00
IUUC-Uma-129547 Ustilago maydis 34.15 7.00e-49 187.00
IUUC-Vda-129689 Verticillium dahliae 29.26 1.00e-36 147.00
IUUC-Vvi-131345 Vitis vinifera 51.32 4.00e-94 338.00
IUUC-Xtr-132136 Xenopus tropicalis 88.64 8.00e-170 589.00
IUUC-Xma-133767 Xiphophorus maculatus 91.25 7.00e-180 622.00
IUUC-Yli-134522 Yarrowia lipolytica 28.53 1.00e-28 120.00
IUUC-Zma-135816 Zea mays 49.17 3.00e-82 298.00
Created Date 25-Jun-2017

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