iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074456

Ensembl Protein ID

ENSOCUP00000007670.3

UniProt Accession

G1SW31; G1SW31_RABIT

Protein Name

Uncharacterized protein

Gene Name

BRWD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000008870.3	ENSOCUT00000008886.3	ENSOCUP00000007670.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-36	121.7	133	170
UBD/Beta-Prp	4.70e-55	186.9	235	492

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH + v+c+af  + +++ +GsdD+ +k+W+++ g+ll
   Q: 133  GHLSAVYCVAFdRTgHRIFTGSDDCLVKIWSTHNGRLL 170
           8**********955599***************999987 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkl......lrslsgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlsl 100
           +++++++++dgt+  w+++ ++l      l+  ++  ++v+ ++  fs  g +l+tgs+D++i+ +   ++ ++ +  l+ h+d+v s+
   Q: 235  QRYMVSTGADGTVCFWQWDLESLkfsprpLKFTEKPRPGVQMLCssFSVGGMFLATGSTDHVIRMYflGFEEPEKIAELESHTDKVDSI 323
           689*****************99999988777778888888755522888888**************99999****************** PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqclee...............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrt 174
           +f+ sgd+++sGs+d t+r+w  e+ ++ +                 ++  +  v++++++++++++v++ +D ++++W++ tg+ll+ 
   Q: 324  QFCNSGDRFLSGSRDGTARIWRFEQLEWRSIlldmatrisgdlsseEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHN 412
           **************************99998999********998877777888*********************************** PP
   S: 175  ltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l g h d v  l+   fd+  + ++s+++dg++ +wdl +g+ ++ + +         v + +fs+++++++++ s+g + i+
   Q: 413  LLG-HADEVFVLEthpFDP--RIMLSAGHDGSIFIWDLTKGTKMKHYFNMIegqghGAVFDCKFSQDGQHFACTDSHGHLLIF 492
           **9.*********777777..99****************999977766544444456677789999***99999999998886 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MEDSESSVQR VFVEEVLSNK HVAPDHLLQI CQRIGPMLDK EIPPSISRVT SLLGAGRQSL 60
LRTAKDCRHT VWKGSAFAAL HRGRPPEMPV NYGSPPNLVE IHRGKQLTGC STFSTAFPGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGACA GTGAATCTTC TGTGCAAAGA GTTTTTGTGG AGGAGGTATG TGTGGTTTCT 60
AGACTTCCAT CCAAAGTCTC CATTTTTCAG CTGAGCATAA TATAATGATC TATGTACCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	29.51	7.00e-53	203.00
IUUC-Aml-002332	Ailuropoda melanoleuca	83.27	0.00e+00	3275.00
IUUC-Apl-004083	Anas platyrhynchos	68.18	0.00e+00	1936.00
IUUC-Aca-004348	Anolis carolinensis	72.51	0.00e+00	1954.00
IUUC-Aly-006517	Arabidopsis lyrata	30.43	4.00e-66	247.00
IUUC-Ath-006577	Arabidopsis thaliana	30.27	3.00e-65	244.00
IUUC-Ame-010718	Astyanax mexicanus	71.02	0.00e+00	1104.00
IUUC-Bta-013217	Bos taurus	86.22	0.00e+00	3552.00
IUUC-Bol-015737	Brassica oleracea	31.50	4.00e-70	260.00
IUUC-Bra-017961	Brassica rapa	31.63	2.00e-70	261.00
IUUC-Cja-019966	Callithrix jacchus	87.03	0.00e+00	3625.00
IUUC-Cfa-021037	Canis familiaris	85.70	0.00e+00	3454.00
IUUC-Cpo-021934	Cavia porcellus	92.11	0.00e+00	2721.00
IUUC-Cre-023003	Chlamydomonas reinhardtii	47.33	2.00e-26	114.00
IUUC-Csa-023352	Chlorocebus sabaeus	87.56	0.00e+00	3447.00
IUUC-Cho-024690	Choloepus hoffmanni	75.34	0.00e+00	1279.00
IUUC-Dre-028508	Danio rerio	60.53	0.00e+00	1642.00
IUUC-Dno-028938	Dasypus novemcinctus	84.57	0.00e+00	3518.00
IUUC-Dme-031752	Drosophila melanogaster	48.60	4.00e-172	599.00
IUUC-Eca-034349	Equus caballus	87.41	0.00e+00	3510.00
IUUC-Fal-037307	Ficedula albicollis	69.78	0.00e+00	2360.00
IUUC-Gga-040865	Gallus gallus	76.27	0.00e+00	2254.00
IUUC-Gac-042435	Gasterosteus aculeatus	57.08	0.00e+00	1565.00
IUUC-Ggo-045500	Gorilla gorilla	88.43	0.00e+00	3621.00
IUUC-Hsa-046350	Homo sapiens	88.38	0.00e+00	3629.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	94.59	0.00e+00	1176.00
IUUC-Lch-049662	Latimeria chalumnae	56.94	0.00e+00	2011.00
IUUC-Lpe-051619	Leersia perrieri	29.62	1.00e-63	239.00
IUUC-Loc-052853	Lepisosteus oculatus	65.21	0.00e+00	1796.00
IUUC-Laf-053848	Loxodonta africana	85.30	0.00e+00	3461.00
IUUC-Mcc-054638	Macaca mulatta	87.85	0.00e+00	3603.00
IUUC-Meu-056739	Macropus eugenii	79.48	0.00e+00	1115.00
IUUC-Mtr-058094	Medicago truncatula	31.25	2.00e-66	248.00
IUUC-Mga-060165	Meleagris gallopavo	76.73	0.00e+00	2235.00
IUUC-Mmr-061227	Microcebus murinus	88.61	0.00e+00	3656.00
IUUC-Mdo-062074	Monodelphis domestica	69.10	0.00e+00	2710.00
IUUC-Mmu-064075	Mus musculus	82.56	0.00e+00	2972.00
IUUC-Mac-065343	Musa acuminata	29.64	1.00e-66	249.00
IUUC-Mpu-066643	Mustela putorius furo	87.23	0.00e+00	2996.00
IUUC-Mlu-067735	Myotis lucifugus	84.16	0.00e+00	3450.00
IUUC-Nle-069402	Nomascus leucogenys	91.63	0.00e+00	2924.00
IUUC-Opr-071032	Ochotona princeps	66.33	2.00e-176	613.00
IUUC-Ont-072298	Oreochromis niloticus	62.29	0.00e+00	1793.00
IUUC-Oan-072954	Ornithorhynchus anatinus	68.70	0.00e+00	2720.00
IUUC-Obr-076619	Oryza brachyantha	30.63	8.00e-63	236.00
IUUC-Ogl-077493	Oryza glaberrima	38.04	3.00e-29	124.00
IUUC-Ola-086648	Oryzias latipes	56.61	0.00e+00	1541.00
IUUC-Olu-087745	Ostreococcus lucimarinus	28.57	3.00e-57	217.00
IUUC-Oga-087938	Otolemur garnettii	80.75	0.00e+00	3148.00
IUUC-Oar-090214	Ovis aries	85.38	0.00e+00	3498.00
IUUC-Ptr-091213	Pan troglodytes	88.43	0.00e+00	3592.00
IUUC-Pan-092444	Papio anubis	87.55	0.00e+00	3583.00
IUUC-Psi-093271	Pelodiscus sinensis	65.42	0.00e+00	2164.00
IUUC-Pma-094427	Petromyzon marinus	67.39	8.00e-111	393.00
IUUC-Ppa-095793	Physcomitrella patens	29.95	1.00e-66	249.00
IUUC-Pfo-097318	Poecilia formosa	62.85	0.00e+00	1736.00
IUUC-Pab-097573	Pongo abelii	87.01	0.00e+00	3520.00
IUUC-Pop-099672	Populus trichocarpa	31.43	8.00e-66	246.00
IUUC-Pca-100759	Procavia capensis	72.15	0.00e+00	1109.00
IUUC-Ppe-101849	Prunus persica	29.72	2.00e-65	245.00
IUUC-Pva-102782	Pteropus vampyrus	85.59	0.00e+00	3523.00
IUUC-Rno-105687	Rattus norvegicus	78.72	0.00e+00	3253.00
IUUC-Sly-111348	Solanum lycopersicum	31.10	3.00e-66	248.00
IUUC-Sar-113519	Sorex araneus	80.48	0.00e+00	1796.00
IUUC-Tgu-116513	Taeniopygia guttata	77.04	0.00e+00	2255.00
IUUC-Tsy-118921	Tarsius syrichta	88.92	0.00e+00	2008.00
IUUC-Tni-120110	Tetraodon nigroviridis	56.99	0.00e+00	1507.00
IUUC-Tca-121098	Theobroma cacao	31.25	6.00e-70	259.00
IUUC-Tbe-127663	Tupaia belangeri	77.18	0.00e+00	1294.00
IUUC-Ttr-128561	Tursiops truncatus	83.66	0.00e+00	3289.00
IUUC-Vpa-130444	Vicugna pacos	83.34	0.00e+00	3308.00
IUUC-Vvi-131362	Vitis vinifera	32.06	1.00e-66	249.00
IUUC-Xma-133633	Xiphophorus maculatus	63.59	0.00e+00	1066.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence