iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037094

Ensembl Protein ID

ENSFALP00000013625.1

UniProt Accession

U3KF21; U3KF21_FICAL

Genbank Protein ID

ENSFALP00000013625

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01010598

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000013039.1	ENSFALT00000013681.1	ENSFALP00000013625.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.20e-116	386.7	559	1281

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ ++++++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 559  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrSFESEINYNNPLGTGGRLAIGFAMLLRALWKGTHHAFQPSKLKAIVASKASQFTG 645
           7******************************99****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c +vs +++p
   Q: 646  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCSKVSITFDP 730
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 731  FLYLPVPLPQKQKVLTVyyfakephkkpikflvsiskenssamevldsvahsvrvkpenlrlaevvknhfhrmflpsnsldtvsptd 817
           ************87555********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 818  lllcfevlspelakervvelqvqqrpqvpsgpvakcaacqkkqlpedeklkrctrcyrvgycnvacqkthwpdhkascrpenigfpf 904
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 905  lisvpesrltyarlaqllegyarysvsvfqppfqlgrmspeqglqplhsatsaselgdgdrisslpqepplspavpelqpemgdttt 991
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 992  vrskvltarssllsldsgfsehmesqgdsccekepsyeralkpeaaipgyqhtpdslsaratqfyitkidaanreqkledkgdtpld 1078
           *************************************************************************************** PP
   S: 186  ..............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkkl 226
                                                         +l++cL+ ftk+e l  e+++yc+kck+++ea+k+l+l++l
   Q: 1079 ltddcslalvwqnnerlkefvlveskelecvedpgsaseaaraghfTLEQCLNLFTKPEVLAPEEAWYCPKCKQHREASKQLMLWRL 1165
           *************************************************************************************** PP
   S: 227  PevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk....... 305
           P+vLi++LkRfsf++  +++ kin+ v+fp + Ldls+fc+ ++ +q +   Y+L+av++H+G++ +GHY+ay++  ++k       
   Q: 1166 PNVLIIQLKRFSFRSFIWRD-KINDMVDFPVRsLDLSKFCIGRKGEQ-QLPMYDLYAVINHYGGMIGGHYTAYARLPNDKnsqrsdv 1250
           ****************8886.*********************88776.5**************************955445567788 PP
   S: 306  .WllfdDskVtevkeeevleetgstaYvlfYkrr 338
            W lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1251 gWRLFDDSTVTTVDESQVVT---RYAYVLFYRRR 1281
           8*******************...********996 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MSSSTNAPGQ RRASRGLDDA TNKKKQKDRA NQESKEGESP SASLWPRQDF GEGELLLDWK 60
QNADEIIIKL NLGSGALKAE DVRADFTDTD CVVKLPDGRQ WSCQFYEEIE GSCSKIQCKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAGCA GCACAAATGC CCCTGGCCAG AGGAGAGCGT CTCGGGGCTT GGATGATGCC 60
ACCAATAAGA AGAAGCAGAA GGATCGAGCC AATCAGGAAA GCAAGGAAGG TGAGAGCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	77.46	0.00e+00	1542.00
IUUC-Apl-003368	Anas platyrhynchos	89.31	0.00e+00	2213.00
IUUC-Aca-004267	Anolis carolinensis	75.54	0.00e+00	1952.00
IUUC-Ame-010970	Astyanax mexicanus	71.96	0.00e+00	1385.00
IUUC-Bta-012905	Bos taurus	76.43	0.00e+00	1526.00
IUUC-Cel-018257	Caenorhabditis elegans	44.56	4.00e-91	329.00
IUUC-Cja-018789	Callithrix jacchus	68.32	0.00e+00	1696.00
IUUC-Cfa-021004	Canis familiaris	78.03	0.00e+00	1525.00
IUUC-Cpo-021529	Cavia porcellus	67.91	0.00e+00	1724.00
IUUC-Csa-024035	Chlorocebus sabaeus	68.01	0.00e+00	1702.00
IUUC-Cho-025036	Choloepus hoffmanni	62.52	0.00e+00	895.00
IUUC-Cin-025451	Ciona intestinalis	42.63	1.00e-83	304.00
IUUC-Dre-028556	Danio rerio	71.88	0.00e+00	1377.00
IUUC-Dno-029240	Dasypus novemcinctus	66.14	0.00e+00	1568.00
IUUC-Dor-030495	Dipodomys ordii	73.90	0.00e+00	982.00
IUUC-Ete-032741	Echinops telfairi	77.25	0.00e+00	1487.00
IUUC-Eca-033661	Equus caballus	68.62	0.00e+00	1757.00
IUUC-Eeu-034648	Erinaceus europaeus	76.25	0.00e+00	658.00
IUUC-Fca-035646	Felis catus	78.01	0.00e+00	1519.00
IUUC-Gmo-038869	Gadus morhua	67.57	0.00e+00	1273.00
IUUC-Gga-041170	Gallus gallus	89.05	0.00e+00	2402.00
IUUC-Gac-041901	Gasterosteus aculeatus	64.58	0.00e+00	1340.00
IUUC-Ggo-044708	Gorilla gorilla	67.97	0.00e+00	1698.00
IUUC-Hsa-046791	Homo sapiens	74.16	0.00e+00	1565.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	66.00	0.00e+00	1657.00
IUUC-Lch-050456	Latimeria chalumnae	53.95	0.00e+00	1307.00
IUUC-Loc-052861	Lepisosteus oculatus	65.05	0.00e+00	1219.00
IUUC-Laf-053788	Loxodonta africana	75.99	0.00e+00	1553.00
IUUC-Mcc-055693	Macaca mulatta	68.40	0.00e+00	1644.00
IUUC-Meu-055921	Macropus eugenii	80.81	0.00e+00	1362.00
IUUC-Mga-059879	Meleagris gallopavo	85.85	0.00e+00	2377.00
IUUC-Mmr-060802	Microcebus murinus	66.39	0.00e+00	1712.00
IUUC-Mdo-061856	Monodelphis domestica	77.56	0.00e+00	1560.00
IUUC-Mmu-063874	Mus musculus	68.55	0.00e+00	1751.00
IUUC-Mpu-066166	Mustela putorius furo	76.02	0.00e+00	1520.00
IUUC-Nle-070161	Nomascus leucogenys	68.22	0.00e+00	1704.00
IUUC-Opr-071015	Ochotona princeps	76.62	0.00e+00	1497.00
IUUC-Ont-072308	Oreochromis niloticus	66.64	0.00e+00	1417.00
IUUC-Oan-072723	Ornithorhynchus anatinus	67.18	0.00e+00	1695.00
IUUC-Ocu-073938	Oryctolagus cuniculus	77.23	0.00e+00	1513.00
IUUC-Ola-086375	Oryzias latipes	71.24	0.00e+00	1370.00
IUUC-Oga-088297	Otolemur garnettii	68.57	0.00e+00	1659.00
IUUC-Oar-089675	Ovis aries	65.86	0.00e+00	1471.00
IUUC-Ptr-091621	Pan troglodytes	74.07	0.00e+00	1562.00
IUUC-Pan-092118	Papio anubis	68.88	0.00e+00	1665.00
IUUC-Pma-094154	Petromyzon marinus	51.20	5.00e-113	401.00
IUUC-Pfo-097246	Poecilia formosa	61.67	0.00e+00	1464.00
IUUC-Pab-098551	Pongo abelii	71.87	0.00e+00	1541.00
IUUC-Pca-100158	Procavia capensis	65.34	0.00e+00	1649.00
IUUC-Pva-103160	Pteropus vampyrus	68.56	0.00e+00	1695.00
IUUC-Rno-105355	Rattus norvegicus	68.52	0.00e+00	1722.00
IUUC-Sha-107057	Sarcophilus harrisii	72.05	0.00e+00	1704.00
IUUC-Sar-113011	Sorex araneus	71.10	0.00e+00	1133.00
IUUC-Ssc-115761	Sus scrofa	66.91	0.00e+00	1672.00
IUUC-Tgu-116956	Taeniopygia guttata	79.79	0.00e+00	1101.00
IUUC-Tru-118739	Takifugu rubripes	68.10	0.00e+00	1392.00
IUUC-Tsy-118827	Tarsius syrichta	84.16	0.00e+00	761.00
IUUC-Tni-119921	Tetraodon nigroviridis	65.67	0.00e+00	1339.00
IUUC-Tbe-128017	Tupaia belangeri	74.32	0.00e+00	1511.00
IUUC-Ttr-128869	Tursiops truncatus	68.19	0.00e+00	1696.00
IUUC-Uma-129498	Ustilago maydis	31.51	7.00e-94	339.00
IUUC-Vpa-130427	Vicugna pacos	73.31	0.00e+00	699.00
IUUC-Xtr-132734	Xenopus tropicalis	63.40	0.00e+00	1622.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence