iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000055385.12	ENSMUST00000212176.1	ENSMUSP00000148512.1
ENSMUSG00000055385.12	ENSMUST00000196652.4	ENSMUSP00000143556.1
ENSMUSG00000055385.12	ENSMUST00000212212.1	ENSMUSP00000148758.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	24390283

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.07	14.8	7	46

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C  C++++ +     +++CgHv++++Cl  +      + ++  C++C+
   Q: 7    CNRCFQSPHRKssFSLTSCGHVYCHSCL--L------KGTKNECVICQ 46
           666777773332233699*********9..5......78888999996 PP

Organism

Mus musculus

Functional Description
(View)

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination.

Protein Sequence
(Fasta)

MASWVFCNRC FQSPHRKSSF SLTSCGHVYC HSCLLKGTKN ECVICQAPCQ TVLLSKHTNS 60
NIQTFFLGID GLCKKYSQET SQISEFQEKH RRRLVAFYQE KISQLEESLR KSVLQIKQLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCAGCT GGGTGTTCTG TAATCGCTGT TTCCAGTCGC CGCACAGGAA GTCGTCCTTC 60
AGCCTGACCA GCTGCGGGCA CGTGTACTGC CACTCCTGCC TCCTCAAAGG TCCGCGTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

Gene Ontology

GO:0005694--C:chromosome
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0051026--P:chiasma assembly
GO:0006311--P:meiotic gene conversion
GO:0016925--P:protein sumoylation
GO:0007131--P:reciprocal meiotic recombination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001870	Ailuropoda melanoleuca	68.39	4.00e-79	286.00
IUUC-Apl-003243	Anas platyrhynchos	49.51	3.00e-50	191.00
IUUC-Ame-010703	Astyanax mexicanus	33.94	7.00e-15	72.40
IUUC-Bta-012656	Bos taurus	30.56	8.00e-15	74.30
IUUC-Cel-018595	Caenorhabditis elegans	23.94	1.00e-09	57.00
IUUC-Cja-019749	Callithrix jacchus	69.79	1.00e-76	280.00
IUUC-Cfa-021065	Canis familiaris	60.50	2.00e-86	312.00
IUUC-Cpo-021724	Cavia porcellus	73.17	6.00e-35	138.00
IUUC-Csa-023944	Chlorocebus sabaeus	74.13	3.00e-84	304.00
IUUC-Cho-024808	Choloepus hoffmanni	25.69	6.00e-08	51.60
IUUC-Cin-025593	Ciona intestinalis	26.40	7.00e-11	61.20
IUUC-Csv-025924	Ciona savignyi	31.36	1.00e-11	62.80
IUUC-Dre-028619	Danio rerio	27.24	5.00e-21	94.70
IUUC-Dno-029599	Dasypus novemcinctus	31.20	2.00e-14	73.20
IUUC-Dor-030719	Dipodomys ordii	29.09	2.00e-10	60.10
IUUC-Dme-031890	Drosophila melanogaster	28.57	2.00e-05	42.40
IUUC-Eca-034173	Equus caballus	29.60	4.00e-14	71.60
IUUC-Fca-035686	Felis catus	27.59	2.00e-14	72.80
IUUC-Fal-036889	Ficedula albicollis	43.63	1.00e-41	162.00
IUUC-Gga-041126	Gallus gallus	43.75	4.00e-53	201.00
IUUC-Ggo-045115	Gorilla gorilla	76.17	2.00e-84	305.00
IUUC-Hsa-045667	Homo sapiens	76.17	1.00e-84	305.00
IUUC-Lch-049607	Latimeria chalumnae	35.96	4.00e-47	181.00
IUUC-Loc-052360	Lepisosteus oculatus	36.97	4.00e-26	109.00
IUUC-Laf-053762	Loxodonta africana	30.40	3.00e-12	65.50
IUUC-Mcc-055392	Macaca mulatta	67.60	6.00e-105	373.00
IUUC-Meu-056211	Macropus eugenii	35.94	2.00e-08	52.40
IUUC-Mga-060189	Meleagris gallopavo	50.90	2.00e-39	154.00
IUUC-Mvi-060451	Microbotryum violaceum	26.83	2.00e-02	33.50
IUUC-Mdo-062424	Monodelphis domestica	58.48	2.00e-71	262.00
IUUC-Mpu-066050	Mustela putorius furo	61.87	3.00e-94	338.00
IUUC-Mlu-067791	Myotis lucifugus	28.74	3.00e-14	72.00
IUUC-Nle-069489	Nomascus leucogenys	74.52	5.00e-64	237.00
IUUC-Opr-070576	Ochotona princeps	30.10	3.00e-12	65.50
IUUC-Ont-072176	Oreochromis niloticus	29.46	7.00e-11	60.80
IUUC-Oan-073698	Ornithorhynchus anatinus	51.30	9.00e-47	179.00
IUUC-Ocu-073927	Oryctolagus cuniculus	68.75	1.00e-63	234.00
IUUC-Ola-087241	Oryzias latipes	36.94	5.00e-20	89.70
IUUC-Oar-089717	Ovis aries	28.08	1.00e-14	73.90
IUUC-Ptr-091122	Pan troglodytes	75.65	1.00e-82	299.00
IUUC-Pan-092892	Papio anubis	67.60	8.00e-105	373.00
IUUC-Pfo-096367	Poecilia formosa	26.61	2.00e-10	59.70
IUUC-Pab-097611	Pongo abelii	76.17	9.00e-85	306.00
IUUC-Pca-100854	Procavia capensis	30.40	4.00e-14	72.00
IUUC-Pva-102370	Pteropus vampyrus	28.80	3.00e-12	65.50
IUUC-Rno-105151	Rattus norvegicus	89.58	3.00e-163	567.00
IUUC-Sha-107525	Sarcophilus harrisii	59.79	4.00e-77	281.00
IUUC-Ssl-108554	Sclerotinia sclerotiorum	30.38	1.00e-02	33.90
IUUC-Tgu-116643	Taeniopygia guttata	47.03	5.00e-47	180.00
IUUC-Tsy-119403	Tarsius syrichta	32.81	3.00e-07	48.90
IUUC-Tbe-127755	Tupaia belangeri	43.61	2.00e-21	95.90
IUUC-Ttr-128969	Tursiops truncatus	67.07	5.00e-32	129.00
IUUC-Vpa-130712	Vicugna pacos	26.71	2.00e-11	62.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence