iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021426

Ensembl Protein ID

ENSCPOP00000007475.2

UniProt Accession

H0VC28; H0VC28_CAVPO

Genbank Protein ID

ENSCPOP00000007475

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AAKN02038210

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000008317.3	ENSCPOT00000008392.2	ENSCPOP00000007475.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	85.91	0.00e+00	919.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Cavia porcellus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKAS GMALLHQIQA SELEPLSRPQ LKMPLEEPQG EVFLDGGKPA VFNYPEGAAY 60
EFNAAAAASA PVYGQPGLAY GPGSEAAAAF GPSSLGGFPQ LSSVSPSPLM LLHPPPQLSP 120

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Nucleotide Sequence
(Fasta)

ATGACCATGA CCCTCCACAC CAAAGCCTCC GGCATGGCCT TGCTGCACCA GATCCAGGCG 60
AGCGAGCTGG AGCCTCTCAG CCGCCCGCAG CTCAAGATGC CCCTGGAGGA GCCGCAGGGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	86.19	0.00e+00	742.00
IUUC-Apl-003688	Anas platyrhynchos	76.99	0.00e+00	778.00
IUUC-Aca-005222	Anolis carolinensis	73.31	0.00e+00	814.00
IUUC-Ame-010731	Astyanax mexicanus	56.03	1.00e-131	462.00
IUUC-Bta-013112	Bos taurus	81.04	0.00e+00	881.00
IUUC-Cja-019408	Callithrix jacchus	86.41	0.00e+00	937.00
IUUC-Cfa-020694	Canis familiaris	82.72	0.00e+00	881.00
IUUC-Csa-023736	Chlorocebus sabaeus	87.06	0.00e+00	826.00
IUUC-Dre-027698	Danio rerio	52.87	4.00e-131	461.00
IUUC-Dno-029477	Dasypus novemcinctus	83.03	0.00e+00	788.00
IUUC-Dor-030572	Dipodomys ordii	87.16	0.00e+00	733.00
IUUC-Ete-032849	Echinops telfairi	67.68	1.00e-179	622.00
IUUC-Eca-033605	Equus caballus	81.04	0.00e+00	882.00
IUUC-Eeu-034683	Erinaceus europaeus	86.92	1.00e-104	372.00
IUUC-Fca-035928	Felis catus	86.58	0.00e+00	742.00
IUUC-Fal-036754	Ficedula albicollis	73.87	0.00e+00	840.00
IUUC-Gmo-038872	Gadus morhua	53.26	3.00e-109	388.00
IUUC-Gga-040988	Gallus gallus	74.71	0.00e+00	831.00
IUUC-Gac-042015	Gasterosteus aculeatus	60.99	1.00e-122	434.00
IUUC-Ggo-044749	Gorilla gorilla	86.24	0.00e+00	928.00
IUUC-Hsa-046944	Homo sapiens	85.91	0.00e+00	926.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	87.12	0.00e+00	940.00
IUUC-Loc-052414	Lepisosteus oculatus	58.30	5.00e-179	620.00
IUUC-Mcc-054781	Macaca mulatta	85.91	0.00e+00	926.00
IUUC-Meu-056232	Macropus eugenii	79.70	0.00e+00	860.00
IUUC-Mga-059319	Meleagris gallopavo	75.21	0.00e+00	836.00
IUUC-Mmr-061636	Microcebus murinus	85.01	7.00e-159	553.00
IUUC-Mdo-062661	Monodelphis domestica	80.54	0.00e+00	870.00
IUUC-Mmu-063330	Mus musculus	86.33	0.00e+00	907.00
IUUC-Mpu-065757	Mustela putorius furo	82.61	0.00e+00	910.00
IUUC-Mlu-067712	Myotis lucifugus	86.73	0.00e+00	819.00
IUUC-Nle-069283	Nomascus leucogenys	84.73	0.00e+00	887.00
IUUC-Opr-070391	Ochotona princeps	84.71	0.00e+00	941.00
IUUC-Ont-071369	Oreochromis niloticus	53.59	4.00e-114	405.00
IUUC-Oan-073734	Ornithorhynchus anatinus	69.08	5.00e-122	430.00
IUUC-Ocu-074292	Oryctolagus cuniculus	85.33	0.00e+00	920.00
IUUC-Oba-075103	Oryza barthii	26.58	5.00e-03	35.80
IUUC-Ogu-079042	Oryza glumaepatula	26.58	1.00e-03	38.50
IUUC-Olo-080944	Oryza longistaminata	26.58	2.00e-03	35.80
IUUC-Oni-082560	Oryza nivara	26.58	4.00e-03	36.20
IUUC-Ola-087052	Oryzias latipes	50.19	1.00e-123	436.00
IUUC-Oga-088586	Otolemur garnettii	86.48	0.00e+00	929.00
IUUC-Oar-090156	Ovis aries	85.01	0.00e+00	773.00
IUUC-Ptr-091321	Pan troglodytes	86.07	0.00e+00	928.00
IUUC-Pan-092851	Papio anubis	85.74	0.00e+00	924.00
IUUC-Psi-093434	Pelodiscus sinensis	74.50	0.00e+00	863.00
IUUC-Pfo-097379	Poecilia formosa	54.49	3.00e-131	461.00
IUUC-Pab-097735	Pongo abelii	85.91	0.00e+00	926.00
IUUC-Pva-102125	Pteropus vampyrus	83.92	0.00e+00	902.00
IUUC-Rno-106121	Rattus norvegicus	86.36	0.00e+00	907.00
IUUC-Sha-107547	Sarcophilus harrisii	80.70	0.00e+00	868.00
IUUC-Sar-113650	Sorex araneus	77.16	3.00e-172	597.00
IUUC-Tgu-117175	Taeniopygia guttata	74.20	0.00e+00	844.00
IUUC-Tru-117545	Takifugu rubripes	53.29	8.00e-135	474.00
IUUC-Tsy-119586	Tarsius syrichta	76.01	0.00e+00	776.00
IUUC-Tni-120121	Tetraodon nigroviridis	53.68	7.00e-135	474.00
IUUC-Tbe-127548	Tupaia belangeri	76.80	2.00e-170	592.00
IUUC-Ttr-128374	Tursiops truncatus	78.19	0.00e+00	818.00
IUUC-Vpa-130464	Vicugna pacos	78.42	1.00e-147	516.00
IUUC-Xtr-132171	Xenopus tropicalis	67.95	0.00e+00	713.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence