iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044783

UUCD1 version

UUC-GoG-00722

Ensembl Protein ID

ENSGGOP00000025332.1

UniProt Accession

G3SB58; G3SB58_GORGO

Protein Name

Tripartite motif-containing protein 5

Gene Name

TRIM5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000014804.2	ENSGGOT00000027365.1	ENSGGOP00000023397.1
ENSGGOG00000014804.2	ENSGGOT00000024063.1	ENSGGOP00000022424.1
ENSGGOG00000014804.2	ENSGGOT00000014856.2	ENSGGOP00000014443.2
ENSGGOG00000014804.2	ENSGGOT00000028312.1	ENSGGOP00000025332.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.90e-09	36.0	36	80
E3 activity/RING/U-box	4.50e-06	27.0	30	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle + + pl+l+CgH f++ Cl + + ++ + ++e +CP+Cr
   Q: 36   CPICLELLTQ-PLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCR 80
           ********99.***************555457788**********8 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl.....asggktcPvtrqplteedlvPnltlrrliqa 67
           v ee  CpI lel ++P  l +G+++ ++++         ++g+++cPv+r + ++e++ Pn  + +++++
   Q: 30   VKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHkksmlDKGESSCPVCRISYQPENIRPNRHVANIVEK 100
           78999*************************975322223377777*****************998887776 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MQGSVNKTSA ARTGRSSGIA SMASGILVNV KEEVTCPICL ELLTQPLSLD CGHSFCQACL 60
TANHKKSMLD KGESSCPVCR ISYQPENIRP NRHVANIVEK LREVKLSPEG QKVDHCARHG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGTTCCTC TAGGAAAATT CCTTTGTGCA GATCAGGCCC GTGGATTGGT GAGTGAATCC 60
TAACCACGTC TTCCCTGGCC TGTCTTCACT CTTCTCCCCA GAATCACCAC TTCTGCAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR032917--TRIM5
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:1990462--C:omegasome
GO:0000932--C:P-body
GO:0008329--F:signaling pattern recognition receptor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410--P:positive regulation of MAPK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0031664--P:regulation of lipopolysaccharide-mediated signaling pathway
GO:0032880--P:regulation of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013110	Bos taurus	57.85	5.00e-156	544.00
IUUC-Cja-019944	Callithrix jacchus	69.80	0.00e+00	670.00
IUUC-Csa-023609	Chlorocebus sabaeus	80.97	0.00e+00	836.00
IUUC-Cho-024416	Choloepus hoffmanni	63.28	3.00e-94	338.00
IUUC-Dor-030700	Dipodomys ordii	52.44	1.00e-142	499.00
IUUC-Ete-033021	Echinops telfairi	54.32	3.00e-123	435.00
IUUC-Hsa-046573	Homo sapiens	92.90	0.00e+00	905.00
IUUC-Mcc-055525	Macaca mulatta	84.54	0.00e+00	853.00
IUUC-Mmr-061336	Microcebus murinus	62.99	2.00e-151	529.00
IUUC-Mlu-067695	Myotis lucifugus	59.19	1.00e-153	536.00
IUUC-Nle-069081	Nomascus leucogenys	86.46	0.00e+00	826.00
IUUC-Opr-071057	Ochotona princeps	52.81	6.00e-127	447.00
IUUC-Oar-090073	Ovis aries	55.60	2.00e-141	495.00
IUUC-Ptr-090927	Pan troglodytes	92.70	0.00e+00	897.00
IUUC-Pan-092730	Papio anubis	84.54	0.00e+00	852.00
IUUC-Pab-098782	Pongo abelii	90.69	0.00e+00	889.00
IUUC-Pca-100502	Procavia capensis	53.17	2.00e-133	468.00
IUUC-Sar-113094	Sorex araneus	50.31	1.00e-111	396.00
IUUC-Ssc-115715	Sus scrofa	57.83	2.00e-143	502.00
IUUC-Tsy-119055	Tarsius syrichta	61.71	5.00e-163	567.00
IUUC-Tbe-127426	Tupaia belangeri	53.52	5.00e-129	454.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence