iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092730

Ensembl Protein ID

ENSPANP00000005557.1

UniProt Accession

A0A096MZZ7; A0A096MZZ7_PAPAN

Genbank Protein ID

ENSPANP00000005557

Protein Name

Tripartite motif-containing protein 5

Genbank Nucleotide ID

AHZZ01061912

Gene Name

TRIM5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000023175.1	ENSPANT00000016421.1	ENSPANP00000005557.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.50e-09	37.6	15	60
E3 activity/RING/U-box	1.50e-07	31.5	9	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl...qkwpglknssskefrCPlCr 46
           C+iCle + + pl+lpCgH f++ C+   ++   ++  + +e +CP+Cr
   Q: 15   CPICLELLTE-PLSLPCGHSFCQACItanHR--KSMLYKEGERSCPVCR 60
           ********99.***************87433..3555689999*****8 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl......asggktcPvtrqplteedlvPnltlrrliqa 67
           v ee  CpI lel ++P  lp+G+++ +++I          ++g+++cPv+r + ++e++ Pn  + +++++
   Q: 9    VKEEVTCPICLELLTEPLSLPCGHSFCQACITANHrksmlyKEGERSCPVCRISYQPENIQPNRHVANIVEK 80
           78999**************************863325555666666*****************998887776 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MASGILLNVK EEVTCPICLE LLTEPLSLPC GHSFCQACIT ANHRKSMLYK EGERSCPVCR 60
ISYQPENIQP NRHVANIVEK LREVKLSPEE GQKVDHCARH GEKLLLFCQE DSKVICWLCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCATTGGC CTGTAGTTTA TCTTTCACTT TCCTGCCCCG ATGTGAGCAA GAATTTCCTG 60
CACTTCCTCT AGGAAAAGTC CTTTGCGCAG ATCAGGGCCC TTGATTGGTG AGTGAATCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR032917--TRIM5
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:1990462--C:omegasome
GO:0000932--C:P-body
GO:0008329--F:signaling pattern recognition receptor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410--P:positive regulation of MAPK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0031664--P:regulation of lipopolysaccharide-mediated signaling pathway
GO:0032880--P:regulation of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013110	Bos taurus	57.96	4.00e-160	557.00
IUUC-Cja-019944	Callithrix jacchus	68.61	0.00e+00	655.00
IUUC-Csa-023609	Chlorocebus sabaeus	92.26	0.00e+00	983.00
IUUC-Cho-024416	Choloepus hoffmanni	63.04	1.00e-93	337.00
IUUC-Dor-030700	Dipodomys ordii	51.61	4.00e-144	504.00
IUUC-Ete-033021	Echinops telfairi	53.02	1.00e-123	436.00
IUUC-Eca-034235	Equus caballus	59.56	1.00e-159	555.00
IUUC-Eeu-034968	Erinaceus europaeus	50.00	2.00e-115	409.00
IUUC-Ggo-044783	Gorilla gorilla	84.54	0.00e+00	822.00
IUUC-Hsa-046573	Homo sapiens	86.92	0.00e+00	862.00
IUUC-Kpa-049392	Komagataella pastoris	34.78	5.00e-10	58.50
IUUC-Mcc-055525	Macaca mulatta	97.38	0.00e+00	1015.00
IUUC-Mmr-061336	Microcebus murinus	62.05	4.00e-155	540.00
IUUC-Mlu-067695	Myotis lucifugus	60.75	7.00e-158	550.00
IUUC-Nle-069081	Nomascus leucogenys	82.49	0.00e+00	815.00
IUUC-Opr-071057	Ochotona princeps	52.23	8.00e-135	473.00
IUUC-Ocu-073956	Oryctolagus cuniculus	58.03	4.00e-156	545.00
IUUC-Oar-090073	Ovis aries	56.01	4.00e-144	504.00
IUUC-Ptr-090927	Pan troglodytes	85.71	0.00e+00	840.00
IUUC-Pab-098782	Pongo abelii	85.71	0.00e+00	855.00
IUUC-Sar-113094	Sorex araneus	49.30	4.00e-117	414.00
IUUC-Ssc-115715	Sus scrofa	56.72	5.00e-146	510.00
IUUC-Tsy-119055	Tarsius syrichta	62.05	3.00e-169	588.00
IUUC-Tbe-127426	Tupaia belangeri	53.60	2.00e-135	475.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence