iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067914

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02007752

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000012227.2	ENSMLUT00000012238.2	ENSMLUP00000011149.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-89	299.8	614	935

Active Site

Position(s)	Description	Evidence
905	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl+ +l+v+f++E g + gGv  ef+++l++e+ +p++g+f+y ++ +++++p + ++    e+ ++F f+G+l+g++l++g++ ++
   Q: 614  NEDLRMELMVSFSEETGYEPGGVRTEFFHCLFEEMTRPEYGMFMYPKEATYMWFPVKPKF----EEKRYF-FFGILCGLILFNGNVANI 697
           679999****************************************************99....566777.99**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           p++ +++k+ll++  sledl+e+ p l +sl+ +++ +++d e       f v+ ++  + ++++L+p+G+ i V+++Nk +Yv+++v+
   Q: 698  PFPLALFKKLLDQTPSLEDLKELSPVLGRSLQILLDDESADFE-----EVFYVHFNVNWDKTDVDLIPNGSCIIVNQSNKTDYVSKYVD 781
           ***********************************87555555.....55666666667889999************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y+++ ++k  +e+f++Gf++v+++e+++ F++eel+ +i G++++d+e+++k++ y +gy +++p+i +Fw++l++++ ee+k+fL F+
   Q: 782  YIFNISVKAVYEEFQRGFYKVCDKEIIEFFHPEELKDMIIGNTDYDWETFEKNAHYGQGYDNSHPTIVMFWKALHKLTLEEKKKFLVFL 870
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg++r+ ++G++++k   f++++++ +++ +++ TCf++L LP+Ys++e ++e L++Ai++++gF+
   Q: 871  TGTDRIQVKGLKSMK-ITFCCPEKGGEKEPIRALTCFSLLYLPKYSTMERVEEALQVAINSNRGFG 935
           ***************.66888888****************************************96 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

IKLGKKMKIH SVDQGAEHVL ILSSDGKPFE YNYSTEHERL QCYSFFQEKT IIQITCGDYH 60
SLALSKGGEL FAWGQNLDGQ LGLGRILDST PTPQLVERLS GVPLAQISAG KAHSVALSMS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTAAGTTAG GGAAAAAAAT GAAGATACAT TCCGTGGACC AAGGAGCAGA GCACGTGCTG 60
ATTCTATCCT CAGATGGAAA ACCATTTGAG TACAACTATA GCACAGAACA TGAAAGGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	82.28	0.00e+00	1621.00
IUUC-Cja-018751	Callithrix jacchus	75.53	0.00e+00	1454.00
IUUC-Cfa-020247	Canis familiaris	82.73	0.00e+00	1600.00
IUUC-Csa-023204	Chlorocebus sabaeus	76.21	0.00e+00	1382.00
IUUC-Cho-025101	Choloepus hoffmanni	64.39	0.00e+00	637.00
IUUC-Dno-029795	Dasypus novemcinctus	71.30	0.00e+00	1076.00
IUUC-Dor-030862	Dipodomys ordii	67.59	0.00e+00	1224.00
IUUC-Ete-032585	Echinops telfairi	60.93	0.00e+00	839.00
IUUC-Eca-034358	Equus caballus	79.68	0.00e+00	1519.00
IUUC-Eeu-035282	Erinaceus europaeus	70.03	0.00e+00	802.00
IUUC-Fca-036505	Felis catus	81.68	0.00e+00	1591.00
IUUC-Ggo-045445	Gorilla gorilla	73.61	0.00e+00	1352.00
IUUC-Hsa-046342	Homo sapiens	76.07	0.00e+00	1417.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	71.81	0.00e+00	1360.00
IUUC-Laf-053921	Loxodonta africana	73.82	0.00e+00	1412.00
IUUC-Mcc-054850	Macaca mulatta	76.10	0.00e+00	1384.00
IUUC-Mmr-060783	Microcebus murinus	66.52	0.00e+00	1211.00
IUUC-Mpu-066123	Mustela putorius furo	80.79	0.00e+00	1578.00
IUUC-Nle-069986	Nomascus leucogenys	76.18	0.00e+00	1456.00
IUUC-Opr-070513	Ochotona princeps	69.52	0.00e+00	962.00
IUUC-Ocu-074305	Oryctolagus cuniculus	73.13	0.00e+00	1386.00
IUUC-Oar-089456	Ovis aries	81.09	0.00e+00	1510.00
IUUC-Ptr-091216	Pan troglodytes	75.98	0.00e+00	1331.00
IUUC-Pan-091706	Papio anubis	75.67	0.00e+00	1377.00
IUUC-Pca-100320	Procavia capensis	67.84	0.00e+00	1291.00
IUUC-Pva-102646	Pteropus vampyrus	84.81	0.00e+00	1610.00
IUUC-Sar-113605	Sorex araneus	76.72	9.00e-154	537.00
IUUC-Tsy-119240	Tarsius syrichta	63.74	0.00e+00	1209.00
IUUC-Tbe-127787	Tupaia belangeri	71.98	0.00e+00	1356.00
IUUC-Ttr-128191	Tursiops truncatus	79.17	0.00e+00	1489.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence